CXC chemokine receptor 1
CXC chemokine receptor 4 expressed in T cells plays an important role in the development of collagen induced arthritis
... columns (n = 6); and WT DBA/1J mice: dark gray columns (n = 6). Data are representative of two independent experiments. (b) T-cell recall proliferative response toward IIC was assessed 1 week after immunization ...
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Children are not little adults: just ask their hematopoietic stem cells
... of CXC chemokine ligand 12 (CXCL12, also known as stromal cell–derived factor 1 [SDF-1]), a chemokine previously implicated in stem cell trafficking to the marrow cavity and shown to be ...
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CXC-Chemokine Receptor 4 Is Not a Coreceptor for Human Herpesvirus 7 Entry into CD4+ T Cells
... in 1% formaldehyde solution in PBS and analyzed by flow cytometry as described before ...Fig. 1, the surface CXCR4 expression and the surface CD4 expression of SupT1 cells incubated with PBS, with the CXCR4 ...
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Study on chemotaxis and chemokinesis of bone marrow-derived mesenchymal stem cells in hydrogel-based 3D microfluidic devices
... therapeutic effect in the patients. The ability of MSCs to produce juxtacrine or paracrine factors is very important to induce regeneration from the endogenous stem cells. Studies have been done previously on some ...
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Relationship between epithelial-to-mesenchymal transition and the inflammatory microenvironment of hepatocellular carcinoma
... IL-8 is another important inflammatory factor secreted by TAMs in HCC. Its expression is associated with tumor growth and survival, as well as increased tumor invasion, migration and angiogenesis. Studies in MHCC97H and ...
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Cell cycle–dependent expression of CXC chemokine receptor 3 by endothelial cells mediates angiostatic activity
... tions of CXCR3-positive vessels were found in some kid- ney tumors in comparison with their normal counter- parts (Figure 1, g and h). When the 1C6 anti-CXCR3 mAb was used, very low or no signal was observed, ...
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CXCR2–CXCL1 axis is correlated with neutrophil infiltration and predicts a poor prognosis in hepatocellular carcinoma
... distinct chemokine expression profiles, which can lead to diverse immune cell infiltration and clinical ...outcomes. CXC receptor 2 (CXCR2) is a member of the G-protein- coupled receptor ...
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Original Article Interaction between CXCR4 and EGFR and downstream PI3K/AKT pathway in lung adenocarcinoma A549 cells and transplanted tumor in nude mice
... CXC chemokine receptor 4 (CXCR4), a member of the G-protein-coupled receptor family, has received considerable attention since it has been demonstrated to be important in tumor metastasis ...
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Initial Assessment of the Role of CXC Chemokine Receptor 4 after Polytrauma
... CXC chemokine receptor (CXCR)-4 agonists have been shown to attenuate inflammation and organ injury in various disease models, including ...Toll-like receptor (TLR)-2 and TLR-4 activation was ...
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SDF-1 Improves Renal Fibrosis in Type 2 Diabetes Mellitus Involving TGF-beta-mediated ECM via PI3K/AKT Signaling
... factor-1, CXC chemokine receptor 4 and F4/80 were ...factor-1, CXC chemokine receptor 4 and F4/80 was significantly increased in the kidney of db/db mice but not in ...
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Preconditioning of bone marrow-derived mesenchymal stromal cells by tetramethylpyrazine enhances cell migration and improves functional recovery after focal cerebral ischemia in rats
... therapeutic strategies for treating ischemic stroke. However, the relatively poor migratory capacity of BMSCs toward infarcted regions limited the therapeutic potential of this approach. Pharmacological preconditioning ...
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Virologic and Immunologic Events in Hilar Lymph Nodes During Simian Immunodeficiency Virus Infection Development of Polarized Inflammation
... inflammatory CXC chemokine receptor 3 (CXCR3) ligands CXCL9, CXCL10, and CXCL11 were all consistently among the most upregulated mRNAs early and late after SIV ...
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Combinatorial treatment of acute myocardial infarction using stem cells and their derived exosomes resulted in improved heart performance
... factor 1 (SDF-1) and its receptor CXC chemokine receptor 4 (CXCR4) has been demonstrated to play a vital role in the recruitment of stem cells to the ischemic myocar- dium ...at ...
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T-Cell-Line-Tropic Human Immunodeficiency Virus Type 1 That Is Made Resistant to Stromal Cell-Derived Factor 1α Contains Mutations in the Envelope gp120 but Does Not Show a Switch in Coreceptor Use
... CXC chemokine receptor 4 (CXCR4) was recently shown to be a coreceptor used by T-cell-line-tropic (T-tropic) human immunodeficiency virus (HIV) strains to enter target cells (5, 27), whereas CC ...
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Expression pattern of CXC chemokine receptor 4 is correlated with lymph node metastasis in human invasive ductal carcinoma
... the receptor has been shown to be highly expressed in human brain tissue [14,15] and colonic epithelial cells ...this chemokine receptor is correlated with metastatic potential and is predictive of ...
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Plasma VCAM1 levels correlate with disease severity in Parkinson’s disease
... CC-chemokine receptor 2; CCR5: CC- Chemokine receptor 5; CD11b: Cluster of differentiation 11B; CXCR3: CXC-chemokine receptor 3; CXCR4: CXC-chemokine ...
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CXCR-4 expression by circulating endothelial progenitor cells and SDF-1 serum levels are elevated in septic patients
... angiogenic potential of EPC [14] and is involved in neu- trophil recruitment in an abdominal sepsis model [27]. A downregulation of the CXC-motive-chemokine receptor-2 on neutrophils in severe sepsis ...
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CXC and CC Chemokine Receptors on Coronary and Brain Endothelia
... Materials and Methods: The expression of chemokine receptors in human brain microvascular endothelial cells (BMVEC) and coronary artery endothelial cells (CAEC).. in vitro and cryostat s[r] ...
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CXCR4 in breast cancer: oncogenic role and therapeutic targeting
... triggers a reduction in breast cancer cell invasiveness both in vitro, and in vivo in murine syngeneic immunocompe- tent breast cancer models, and they found that AMD3465 inhibited breast tumor initiation and metastases ...
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Impairment of circulating endothelial progenitor cells (EPCs) in patients with glucocorticoid-induced avascular necrosis of the femoral head and changes of EPCs after glucocorticoid treatment in vitro
... a receptor of SDF-1, downregu- lation of CXCR7 in EPCs by GCs may also explain why EPCs from GC-induced ANFH patients had decreased migratory ability when SDF-1 was used as chemo- ...
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