Cyclic nucleotide phosphodiesterase
Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B–null mice
... Cyclic nucleotide phosphodiesterase 3B (PDE3B) has been suggested to be critical for mediating insulin/IGF-1 inhibition of cAMP signaling in adipocytes, liver, and pancreatic b ...
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Expression and characterisation of a novel cyclic nucleotide phosphodiesterase Type lA from dog heart
... al, 1980,1986a, 1986b; Kincaid < 2 /., 1984). PDEl enzymes from these tissues exhibited different molecular masses as determined by SDS PAGE analysis as well as displaying differing biochemical properties. For ...
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Transient hypercapnia reveals an underlying cerebrovascular pathology in a murine model for HIV-1 associated neuroinflammation: role of NO-cGMP signaling and normalization by inhibition of cyclic nucleotide phosphodiesterase-5
... a phosphodiesterase 5 (PDE5) inhibitor that prevents degradation of cGMP [24,25], and 2) tetrahydrobiopterin (BH4) which is a lim- iting cofactor necessary for NO production ...
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Calmodulin stimulated cyclic nucleotide phosphodiesterase (PDE1C) is induced in human arterial smooth muscle cells of the synthetic, proliferative phenotype
... The data presented may also have direct relevance to clini- cal studies involving cyclic nucleotides and smooth muscle pro- liferation. For example, attempts to treat restenosis after coro- nary angioplasty using ...
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The role of cyclic nucleotides and cyclic nucleotide phosphodiesterase in development of Mysococcus santus analysis of mutants.
... aggregation or sporulatwn. Type II strains were able to aggregate but did not spbrulate, A strain classed as a Type III strain was a low capacity fruiter. r Each category displayed defects in cyclic ...
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Cyclic nucleotide phosphodiesterase 3A–deficient mice as a model of female infertility
... completely infertile, because ovulated oocytes were arrested at the germinal vesicle stage and, therefore, could not be fertilized. Pde3a –/– oocytes lacked cAMP-specific PDE activity, contained increased cAMP levels, ...
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Inhibitors of cyclic nucleotide phosphodiesterase isozymes type III and type IV suppress mitogenesis of rat mesangial cells
... cAMP- phosphodiesterase (PDE) isozyme PDE-III, inhibited mitogenesis to similar extent as forskolin and DBcAMP and activated in situ PKA, but without detectable increase in cAMP ...
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cGMP stimulated cyclic nucleotide phosphodiesterase regulates the basal calcium current in human atrial myocytes
... of cyclic nucleotides is not only regulated at the level of synthesis but also at the level of ...by cyclic nucleotide phosphodiesterases (PDEs), which break down cAMP and cGMP into 5 9 -AMP and 5 9 ...
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Cyclic nucleotide phosphodiesterase 3B is connected to osteopontin and protein kinase CK2 in pancreatic β cells
... Islets from RIP-PDE3B mice, exhibiting β-cell spe- cific overexpression of the cAMP/cGMP-degrading enzyme phosphodiesterase 3B (PDE3B) and dysregu- lated insulin secretion, were subjected to microarray analysis. ...
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Rieder, Florian (2004): Wirkung der spezifischen Phosphodiesterase-Inhibitoren Roflumilast und Pumafentrine im Mausmodell der Dextran-Sodium-Sulfat-induzierten Kolitis. Dissertation, LMU München: Medizinische Fakultät
... Emesis induced by inhibitors of type IV cyclic nucleotide phosphodiesterase. (PDE IV) in the ferret[r] ...
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Adenyl cyclases and cAMP in plant signaling - past and present
... of cyclic AMP in higher plants does not permit us to indulge in speculation on its function and thus to increase the disparity between available facts and conclusions, which are based solely on the conviction that ...
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Molecular Mechanisms of a Retinal Cyclic Nucleotide-Gated Channel
... the blocker (Armstrong, 1971). This model has been used to explain how raising the permeant ion concentration on the opposite side of the membrane lowers the apparent blocker affinity, a phenomenon sometimes dubbed the ...
165
In vitro behavior of human intestinal mucosa The influence of acetyl choline on ion transport
... The possibility that the autonomic nervous system may influence the function of intestinal mucosa was investigated by assessing the effect of acetyl choline on ion transport in human intestine. Isolated pieces of ...
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Clinical Decision Making of Nurses Regarding Elder Abuse
... phosphate buffer perchloric acid pars distalis of the pituitary gland 3’5’cyclic AMP phosphodiesterase pars distalis removal pelvic ganglia prostaglandins prostaglandin E2 prostaglandin [r] ...
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Phosphodiesterase 2A as a therapeutic target to restore cardiac neurotransmission during sympathetic hyperactivity
... The role of PDE2-mediated cGMP hydrolysis in cardiac sympathetic neurons. cAMP and cGMP cross-talk is regulated by the PDE family that is considered important in maintaining cell-signaling processes and cyclic ...
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Oscillations of cyclic nucleotide concentrations in relation to the excitability of Dictyostelium cells
... After, however, calcium had been returned, the cyclic nucleotide concentrations remained at the basal levels, similar to the suppression of the second cGMP and cAMP peaks in excitable ce[r] ...
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Modulation of cyclic nucleotide gated channels and regulation of vertebrate phototransduction
... activation) could result in a change in visual sensitivity, either in response to signals external to an organism, such as light itself during light and dark adaptation, or in response to internal signals, such as ...
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Regulation of endothelial cell cyclic nucleotide metabolism by prostacyclin
... An analysis of prostaglandin-stimulated adenosine 3',5'-cyclic monophosphate (cyclic AMP) accumulation in cultured human umbilical vein endothelial cells showed prostacyclin (PGI2) to be the most potent ...
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A GENETICALLY DISTINCT FORM OF CYCLIC AMP PHOSPHODIESTERASE ASSOCIATED WITH CHROMOMERE 3D4 IN DROSOPHILA MELANOGASTER
... Effects of cations on cAMP hydrolysis: The CAMP phosphodiesterase activity present in homogenates of Basc/w+Y flies is a function of the Mg++ concentra- tion, as shown in[r] ...
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ASSOCIATION OF PHOSPHODIESTERASE 8B GENE POLYMORPHISM (RS4704397) IN SUDANESE WOMEN WITH HYPERTHYROIDISM
... (A) nucleotide is replaced by a guanine ...increased phosphodiesterase activity in PDE8B, thereby reducing the ability of the thyroid gland to generate free T4 when stimulated by TSH [17] these differences ...
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