Cyclin D2
CD274 promotes cell cycle entry of leukemia-initiating cells through JNK/Cyclin D2 signaling
... of Cyclin D2 and CDK6 were decreased in CD274-null LICs compared to WT ones ...of Cyclin D2, which is a key regulator in promoting G1-S transition of cell cycle [28], was most significantly ...
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Regulation of sonic hedgehog GLI1 downstream target genes PTCH1, Cyclin D2, Plakoglobin, PAX6 and NKX2 2 and their epigenetic status in medulloblastoma and astrocytoma
... the Cyclin D2 promoter in U87MG cells, there was no change in Cyclin D2 expression after ...the Cyclin D2 promoter in 8 cell lines and 44 astrocytic tumors by studying two ...
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Transcriptional Up-Regulation of the Cyclin D2 Gene and Acquisition of New Cyclin-Dependent Kinase Partners in Human T-Cell Leukemia Virus Type 1-Infected Cells
... kilodaltons. Cyclin D2 protein was seen at higher levels in HTLV-1-infected cells, as evident in lanes 2 and ...other cyclin D2 monoclonal antibodies, DCS-3 and DCS-5 (Neomarkers, Union City, ...
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Influence of miRNA-106b and miRNA-135a on butyrate-regulated expression of p21 and Cyclin D2 in human colon adenoma cells
... of Cyclin D2. It could be shown that Cyclin D2 along with other Cyclins (D1, D3) is overexpressed in colon tumors and colon cancer cells like HT29 cells (Mermelshtein et ...that Cyclin ...
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The role of cyclin D2 and p21/waf1 in human T cell leukemia virus type 1 infected cells
... of cyclin/cdk complexes it would be expected that p21/waf1 would slow down the cell cycle or even cause a G 1 /S ...with cyclin D2 it can be viewed as a positive regulator of the cell ...for ...
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De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome
... between cyclin D2 and this pathway in vivo, we examined the levels of CCND2 in ...in cyclin D2, equivalent to the increase in cyclin D1 .... Cyclin D2 promotes neuronal ...
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Transcriptional Coactivator CBP Facilitates Transcription Initiation and Reinitiation of HTLV-I and Cyclin D2 Promoter
... HTLV-I is the etiologic agent for adult T-cell leukemia/lymphoma (ATL) and HTLV-I- associated myelopathy/tropical spastic paraparesis (HAM/TSP). Taxi, the major activator of this virus, is a 40- kDa (353 amino acid) ...
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Epstein-Barr Virus Nuclear Antigen 3C Facilitates Cell Proliferation by Regulating Cyclin D2
... Flag-tagged cyclin D2 and DsRed (red fluorescent protein)-fused ...Flag-tagged cyclin D2 was incubated with mouse anti-Flag (M2) antibody followed by Alexa Fluor 488-conjugated secondary ...
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Gris1, a New Common Integration Site in Graffi Murine Leukemia Virus-Induced Leukemias: Overexpression of a Truncated Cyclin D2 due to Alternative Splicing
... the cyclin D2 gene located 85 kbp ...the cyclin D2 gene: the already-characterized ...the cyclin D2 protein. Deregulated expression of the cyclin D2 gene has also ...
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Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells
... Epigenetic silencing through promoter hypermethylation and histone deacetylation is responsible for transcrip- tional repression of numerous tumor suppressor genes and growth regulatory genes in cancer cells [32-34]. A ...
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Selective cortical interneuron and GABA deficits in cyclin D2 null mice
... anti-cyclin D2 ( ␣ - cD2; AB-4, Lab Vision; 1:1000), anti-cyclin D1 ( ␣ -cD1; SP4, Lab Vision; 1:5000), anti-Ki67 ( ␣ -Ki67; SP6, Lab Vision; 1:1000), anti-BrdU ( ␣ -BrdU; RPN20EZ, Amersham; 1:50), ...
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Investigation of the Cyclin D3-Cyclin D2 Negative Feedback Loop.
... and include proteins involved in DNA and chromosomal replication. E-type cyclins are also important transcriptional targets of E2F transcription factors, as they are required for CDK2 activation and proper completion of ...
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miR-4317 suppresses non-small cell lung cancer (NSCLC) by targeting fibroblast growth factor 9 (FGF9) and cyclin D2 (CCND2)
... In this study, another new direct and functional target of miR-4317, CCND2, was also identified. CCND2 is a well-known cyclin that functions in the cell cycle, specif- ically in G1/S transition. We further ...
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SMYD3 contributes to a more aggressive phenotype of prostate cancer and targets Cyclin D2 through H4K20me3
... To identify putative target genes of SMYD3 histone methyltransferase activity, expression profile of selected genes involved in cell cycle, apoptosis, DNA repair, mTOR and MAPK/ERK pathw[r] ...
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Modulation of cell cycle dynamics is required to regulate the number of cerebellar GABAergic interneurons and their rhythm of maturation
... of cyclin D2, and the ensuing regulation of proliferation rates and neuronal production, is under control of environmental ...addition, cyclin D2 is a direct transcriptional target of sonic ...
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The cell cycle as a brake for β-cell regeneration from embryonic stem cells
... Cdk4–cyclin D2 initiated ac- tive proliferation of adult pancreatic progenitor cells that existed within the islets ...Cdk4– cyclin D2 complex prior to β-cell differentiation protocols seems ...
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Direct and Indirect Regulation of Cytokine and Cell Cycle Proteins by EBNA-2 during Epstein-Barr Virus Infection
... increased cyclin E/cdk2 kinase activity. The p27 is sequestered by cyclin D2/cdk4 complexes presumably formed following c-myc-induced activation of the cyclin D2 gene ...
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Novel Regulation of the Cell Cycle During Cell Fate Decisions in the Central Nervous System
... D-type Cyclin function is essential in regulation of the early, mitogen dependent portion of G1 phase that is speculated to constitute a critical period during which cell fate decisions are made (Takahashi, ...
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β cell replication is the primary mechanism for maintaining postnatal β cell mass
... of cyclin D2 expression and lower levels of cyclin D3 in the developing pancreas (Figure ...that cyclin D2 expression was confined to the nucleus of pancreatic epithe- lial cells and ...
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Original Article Expression of cell-cycle regulators is associated with invasive behavior and poor prognosis in prolactinomas
... Abcam); Cyclin D1 (ab21699, 1/100; Abcam); Cyclin E1 (ab9517, 1/30; Abcam); p16 (ab54- 210, 1/1500; Abcam); p27 (ab32304, 1/500; Abcam); Cdk2 (ab77671, 1/600; Ab- cam); Cdk4 (ab108357, 1/ 400; ...
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