Cyclin-dependent kinase 11
The emerging roles and therapeutic potential of cyclin- dependent kinase 11 (CDK11) in human cancer
... CDK11 is composed of an N-terminal regulatory region, which has multiple nuclear localization signals (NLS) and a 14-3-3 consensus site, and a carboxy-terminal (C-terminal) catalytic domain that is responsible for its ...
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Modulation of apoptosis by the cyclin dependent kinase inhibitor p27Kip1
... 1997. Cyclin kinase inhibitors are increased during experimental membranous nephropathy: potential role in limiting glomerular epithelial cell proliferation in ...52:404–413. 11. Rosenblatt, J., Gu, ...
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Insights into the clinical value of cyclin dependent kinase 5 in glioma: a retrospective study
... CDK5, one of the major kinases activated by its regu- lators p35 or p39, directly phosphorylates various resi- dues and simultaneously regulates various substrates [7]. Evidence indicates that CDK5 may have extra ...
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Cyclin-Dependent Kinase Inhibitor AT7519 as a Potential Drug for MYCN-Dependent Neuroblastoma.
... The work presented here describes the preclinical evaluation of the novel fragment-derived small molecule CDK inhibitor AT7519 in neuroblastoma treatment. In agreement with our previous results, the sensitivity of ...
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Regulation of the G1-S transition by cyclin-dependent kinase inhibitors
... Human and murine cells senesce when grown in culture, but the dominant mechanism of growth arrest appears to be different. In many human (1, 10, 11, 19, 22, 47, 69, 71, 73) and some murine (70, 81) cell types, ...
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Retroviral Cyclin Enhances Cyclin-Dependent Kinase-8 Activity
... a cyclin box fold (29, 40, 45, ...a cyclin box fold, which is responsible for binding to cyclin-dependent kinase-8 (CDK8) (9, 29, ...CDK8, cyclin C, and Mediator proteins Med12 ...
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<p>New Isatin–Indole Conjugates: Synthesis, Characterization, and a Plausible Mechanism of Their in vitro Antiproliferative Activity</p>
... B1, cyclin D1, and phos- phorylated cyclin-dependent kinase 1), and a pro-apoptotic protein (Bcl-2-associated X protein gene), and activated ...
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Cyclin-dependent kinase 2 is an ideal target for ovary tumors with elevated cyclin E1 expression
... CCNE1 mainly coordinates with Cdk2 to facilitate G1/S progression of cell cycle [11]. In ovarian cancer cells, enforcing CCNE1 expression stimulates cell proliferation [6] and increases colony formation [12]. ...
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Omega 3 polyunsaturated fatty acids inhibit cell proliferation by regulating cell cycle in fad3b transgenic mouse embryonic stem cells
... of cyclin D1 and cyclin E in one study [11], but decreased expression of the Cdk2 and cyclin E proteins and induced apoptosis in an- other study ...the cyclin ...
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Proteomic analysis of differentially expressed proteins in hepatitis B virus-related hepatocellular carcinoma tissues
... protein kinase 1 and Protein ...named Cyclin- dependent kinase inhibitor p12, Cyclin-dependent kinase inhibitor 1, Antioxidant protein 2, Protein disulfide iso- merase A2, ...
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Loss of G1/S Checkpoint in Human Immunodeficiency Virus Type 1-Infected Cells Is Associated with a Lack of Cyclin-Dependent Kinase Inhibitor p21/Waf1
... of cyclin E-associated complex in both infected and uninfected ...for kinase assays with histone H1 or GST-Rb as ...and cyclin E in infected and uninfected ...
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Transcriptional Downregulation of p27KIP1 through Regulation of E2F Function during LMP1-Mediated Transformation
... The current study also has implications for the development of EBV-associated cancers. Both the Rb and p53 tumor sup- pressor pathways are almost always deregulated during malig- nant transformation. Other DNA tumor ...
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Retroviral Cyclin Controls Cyclin-Dependent Kinase 8-Mediated Transcription Elongation and Reinitiation
... exogenous cyclin C. Ob- viously, increased levels of a CDK8-activating cyclin, whether RV- cyclin or cyclin C, can increase the output of IEG ...RV- cyclin expression will always be ...
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Cyclin dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis
... Calreticulin expression is regulated by a pathway that includes CDKN2B, retinoblastoma, and E2F4. To investigate the molecular link between CDKN2B and CALR, we next examined the CALR promoter for putative transcription ...
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Overexpression of p53 activated by small activating RNA suppresses the growth of human prostate cancer cells
... examined Cyclin D1–CDK4/6 expression after cotreatment with dsP53-285 and ...on Cyclin D1–CDK4/6 mRNA and protein expression were downregulated after cotransfection of siP53 in LNCaP and DU145 cells (Figure ...
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Use of cyclin-dependent kinase (CDK) 4/6 inhibitors for hormone receptor-positive, human epidermal growth factor receptor 2-negative, metastatic breast cancer: a roundtable discussion by The Breast Cancer Therapy Expert Group (BCTEG)
... cyclin D1 is produced, and interacts with CDKs 4 and 6 to form a complex which phosphorylates pRb and lifts the repression on E2F, allowing it to activate downstream tar- gets, and permitting quiescent cells to ...
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Functional Interactions between Herpesvirus Oncoprotein MEQ and Cell Cycle Regulator CDK2
... Cell cycle-dependent cytoplasmic translocation of MEQ proteins. To study the biochemical and transformation prop- erties of MEQ in isolated form, we previously established Rat-2 (MEQ) cells, a pool of clones ...
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Pharmacokinetics and biodistribution of the cyclin-dependent kinase inhibitor -CR8- in mice
... cell death induction. The drug passes the BBB at a level sufficient to reach concentrations able to inhibit neur- onal kinase targets. Bone marrow exposure was about 30% of that found as systemic exposure, a ...
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The cyclin-dependent kinase PITSLRE/CDK11 is required for successful autophagy
... the cyclin- dependent kinase, PITSLRE and its human ortholog CDK11 as critical regulators of basal ...(CDC)-related kinase belonging to the p34 cdc2 ...
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Regulatory mechanisms of B cell responses and the implication in B cell-related diseases
... demonstrated that doxycycline withdrawal resulted in suppression of mir-155 expression and subsequent tumor shrinkage [89]. In this mouse model, anti-miR- 155 treatment resulted in decreased tumor burden, indi- cating ...
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