Cyclin-dependent kinase 4
Cyclin-dependent kinase 4 is a preclinical target for diet-induced obesity
... The tumor suppressor pRb binds and represses the E2F family transcription factors, acting as a master regulator of the G 1 to M checkpoint during the cell cycle. In adult neurons, pRb is critical for maintaining the ...
16
Therapeutic effect of palbociclib in chondrosarcoma: implication of cyclin-dependent kinase 4 as a potential target
... chemotherapy. Cyclin-dependent kinase 4 (CKD4) is highly expressed in human cancer, and palbociclib, the inhibitor of CDK4 has been used clinically under FDA approval for application in cancer ...
12
Genetic and pharmacologic regulation of cyclin dependent kinase 4 and 6 activity in mammalian hematopoiesis
... serine/threonine kinase that phosphorylates a wide variety of substrates to effect the ultimate cellular outcome: repair, senescence, or cell ...p53- dependent responses (reviewed in ...a kinase that ...
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INHIBITION STUDIES OF TERPENE BASED NATURAL PRODUCTS WITH CYCLIN DEPENDENT KINASE 4 (CDK4 MIMIC CDK2)
... Table 4 reports the binding energies, hydrogen bonding (HB), amino acids involved in HB and the HB distances of the selected five molecules. It is reported that these molecules are having binding energies higher ...
8
Aristizabal Prada, Elke Tatjana (2018): Preclinical in vitro investigation to evaluate novel molecular targeted therapy options for neuroendocrine neoplasms. Dissertation, LMU München: Medizinische Fakultät
... Novel Cyclin- Dependent Kinase 4/6 Inhibitor Ribociclib (LEE011) Alone and in Dual-Targeting Approaches Demonstrates Antitumoral Efficacy in Neuroendocrine Tumors in ...Targeting ...
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Regulatory mechanisms of B cell responses and the implication in B cell-related diseases
... demonstrated that doxycycline withdrawal resulted in suppression of mir-155 expression and subsequent tumor shrinkage [89]. In this mouse model, anti-miR- 155 treatment resulted in decreased tumor burden, indi- cating ...
13
ER-α36: a novel biomarker and potential therapeutic target in breast cancer
... protein kinase B; BCSCs, breast cancer stem cells; cdk 4, cyclin-dependent kinase 4; eR-α36, estrogen receptor-alpha36; eR-α66, estrogen receptor- alpha66; eRes, estrogen ...
9
Omega 3 polyunsaturated fatty acids inhibit cell proliferation by regulating cell cycle in fad3b transgenic mouse embryonic stem cells
... G1/S-specific cyclin-D1; Ccne1: G1/S-specific cyclin-E1; Cdk2: Cyclin- dependent kinase 2; Cdk4: Cyclin-dependent kinase 4; Cdk6: ...
9
Overexpression of p53 activated by small activating RNA suppresses the growth of human prostate cancer cells
... of Cyclin D1 and cyclin-dependent kinase 4/6, thereby inducing PCa cell cycle arrest in G0/G1 phase and then inhibiting cell proliferation and ...
11
The cyclin-dependent kinase PITSLRE/CDK11 is required for successful autophagy
... later time points it is clear that autophagosome turnover is signifi- cantly retarded, although not completely blocked. How then can we explain these different effects on autophagy at different times? As no substrates of ...
7
Landscape of genomic alterations in high-grade serous ovarian cancer from exceptional long- and short-term survivors
... CCNE1: Cyclin E 1; CD4: Cluster of differentiation 4; CD8: Cluster of differentiation 8; CDK12: Cyclin dependent kinase 12; CNV: Copy number variation; DLEU1: Deleted in lymphocytic ...
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Regulation of the G1-S transition by cyclin-dependent kinase inhibitors
... p18 Ink4c induces expression of other cdk inhibitors, specifically p16 Ink4a in a tissue specific fashion in vivo. It is possible that changes in cdk inhibitor levels could be a non-cell autonomous effect due increased ...
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Cyclin-dependent kinase 2 is an ideal target for ovary tumors with elevated cyclin E1 expression
... Elevation of CCNE1 level has been reported in various histological types of human ovarian tumors including HGSOC [5, 7]. Integrated analysis of ovarian carcinoma from the study of TCGA further showed thatCCNE1 gene is ...
12
Cip/Kip cyclin-dependent protein kinase inhibitors and the road to polyploidy
... Recent analysis of the differentiation of mouse trophob- last stem (TS) cells into trophoblast giant (TG) cells has revealed that endoreduplication is triggered by suppres- sion of CDK1 activity by the CDK specific ...
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Modulation of apoptosis by the cyclin dependent kinase inhibitor p27Kip1
... p27 also protects rat cells from apoptosis. To determine if p27 also protected cells from other species from apoptosis, p27 levels were lowered in rat mesangial cells and rat fibroblasts with antisense ...
9
<p>Current Therapeutic Progress of CDK4/6 Inhibitors in Breast Cancer</p>
... mBC/ABC. 4 Moreover, the combination of ET and cyclin-dependent kinase (CDK) 4/6 inhibitors has also shown signi fi cantly clinical bene fi ...
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Cyclin-Dependent Kinase Inhibitor AT7519 as a Potential Drug for MYCN-Dependent Neuroblastoma.
... in the development of in vivo xenograft models of neuroblastoma. However, xenograft models still have the principal drawback that they lack an intact immune system (24). We therefore complemented our xenograft studies ...
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Cyclin dependent kinase regulation in haemopoietic cells
... level of compensation is set until it is no longer detected (Figure 4.10). Similarly, the PE-labelled cells should only be detected in the PE channel and observed as unstained in the FITC channel. In this application ...
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Proteomic analysis of differentially expressed proteins in hepatitis B virus-related hepatocellular carcinoma tissues
... protein kinase 1 and Protein ...named Cyclin- dependent kinase inhibitor p12, Cyclin-dependent kinase inhibitor 1, Antioxidant protein 2, Protein disulfide iso- merase A2, ...
10
Pharmacokinetics and biodistribution of the cyclin-dependent kinase inhibitor -CR8- in mice
... CR8 was dissolved in DMSO: 50 mM HCl (10:90 v/v). The first group of mice received i.v. doses of CR8 (50 mg/kg body weight), the second received oral doses of CR8 (100 mg/kg body weight) and three control mice received ...
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