Cyclin-dependent kinase 6
MicroRNA 495 inhibits proliferation of glioblastoma multiforme cells by downregulating cyclin dependent kinase 6
... enzyme cyclin-dependent kinase 6 (CDK6) is over-expressed in GBM [4,5], although not all the over-expression can be explained by genomic amplification, suggesting that other gene regulatory ...
8
MicroRNA-320c inhibits tumorous behaviors of bladder cancer by targeting Cyclin-dependent kinase 6
... adjacent normal mucosal tissues. Compared with their non-cancerous counterparts, it was observed that miR- 320c expression levels were lower in cancerous tissues, and 6 out of 13 samples illustrated a 50% ...
12
Omega 3 polyunsaturated fatty acids inhibit cell proliferation by regulating cell cycle in fad3b transgenic mouse embryonic stem cells
... G1/S-specific cyclin-D1; Ccne1: G1/S-specific cyclin-E1; Cdk2: Cyclin- dependent kinase 2; Cdk4: Cyclin-dependent kinase 4; Cdk6: Cyclin-dependent ...
9
Regulation of the G1-S transition by cyclin-dependent kinase inhibitors
... While the studies presented here focused on tissues which showed a hyperproliferation upon p16 Ink4a and p18 Ink4c loss, we have embarked on a more extensive study of tissues affected by cdk4/6 inhibition in an ...
103
Cyclin dependent kinase 12, a novel drug target for visceral leishmaniasis
... Extended Data Table 6: Sensitivity of WT and compound 5-resistant intramacrophage amastigotes INMAC to the compound series... Host cell pXC50..[r] ...
33
Cyclin-dependent kinase 2 is an ideal target for ovary tumors with elevated cyclin E1 expression
... Although we failed to detect a clear correlation between CCNE1 level and malignancies in both established ovarian cancer cell lines as well as primary tumor specimens (Figures 1 and 2), the frequent CCNE1 gene ...
12
Genetic and pharmacologic regulation of cyclin dependent kinase 4 and 6 activity in mammalian hematopoiesis
... Prevention of G1-S traversal is an alternative mechanism that can explain the radiomitigation effects of CDK4/6 inhibitors. Attempted G1-S traversal in the setting of unrepaired DNA damage is a particularly toxic ...
97
The cyclin-dependent kinase PITSLRE/CDK11 is required for successful autophagy
... in 6 well plates were trans- fected with Oligofectamine (Invitrogen, 12252-011) according to the manufacturer’s instructions, using 10 nM oligonucleotide ...
7
Penta O galloyl β D glucose induces G1arrest and DNA replicative S phase arrest independently of P21 cyclin dependent kinase inhibitor 1A, P27 cyclin dependent kinase inhibitor 1B and P53 in human breast cancer cells and is orally active against triple negative xenograft growth
... protein kinase), a well-known autophagy signaling kinase in response to nutrient deprivation [18]; and by increased phosphatidylethanolamine modification of the microtu- bule-associated protein 1 light ...
11
Cyclin dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis
... Traditional risk factors account for approximately half of an indi- vidual’s lifetime risk of cardiovascular disease (1, 2). The balance, therefore, is accounted for by a combination of unmeasured envi- ronmental ...
16
Pharmacokinetics and biodistribution of the cyclin-dependent kinase inhibitor -CR8- in mice
... CR8 was dissolved in DMSO: 50 mM HCl (10:90 v/v). The first group of mice received i.v. doses of CR8 (50 mg/kg body weight), the second received oral doses of CR8 (100 mg/kg body weight) and three control mice received ...
9
<p>Current Therapeutic Progress of CDK4/6 Inhibitors in Breast Cancer</p>
... selective cyclin-dependent kinase (CDK) 4/6 inhibitors has signi fi cantly improved the prognosis of patients with hormone receptor (HR)-positive human epidermal growth factor receptor 2 ...
11
Cyclin-Dependent Kinase Inhibitor AT7519 as a Potential Drug for MYCN-Dependent Neuroblastoma.
... At 6 h after administration of the last dose, tumour samples were collected for immunohistochemistry analysis of cleaved caspase 3 and hematoxylin-eosin ...
22
Downregulation of cyclin dependent kinase 2 activity and cyclin A promoter activity in vascular smooth muscle cells by p27(KIP1), an inhibitor of neointima formation in the rat carotid artery
... units) and 90 m l of 15% (wt/vol) Poloxamer 407 (BASF Corp., Parsip- pany, NJ). This pluronic gel has been shown to enhance adenovirus infectivity in VSMC in vitro and after angioplasty in the rat carotid artery (51, ...
9
Emerging Roles for Ciz1 in Cell Cycle Regulation and as a Driver of Tumorigenesis
... the cyclin-dependent ...cycle 6 (Cdc6) interactions and aids localization of cyclin A- cyclin-dependent kinase 2 (CDK2) activity to chromatin and the nuclear matrix during ...
15
Modulation of apoptosis by the cyclin dependent kinase inhibitor p27Kip1
... p27 also protects rat cells from apoptosis. To determine if p27 also protected cells from other species from apoptosis, p27 levels were lowered in rat mesangial cells and rat fibroblasts with antisense ...
9
Overexpression of p53 activated by small activating RNA suppresses the growth of human prostate cancer cells
... of Cyclin D1 and cyclin-dependent kinase 4/6, thereby inducing PCa cell cycle arrest in G0/G1 phase and then inhibiting cell proliferation and ...
11
Aristizabal Prada, Elke Tatjana (2018): Preclinical in vitro investigation to evaluate novel molecular targeted therapy options for neuroendocrine neoplasms. Dissertation, LMU München: Medizinische Fakultät
... Novel Cyclin- Dependent Kinase 4/6 Inhibitor Ribociclib (LEE011) Alone and in Dual-Targeting Approaches Demonstrates Antitumoral Efficacy in Neuroendocrine Tumors in ...Targeting ...
22
Retroviral Cyclin Enhances Cyclin-Dependent Kinase-8 Activity
... of kinase assay blots with specific antibodies did not detect CDK8 in anti-CDK7 or anti-CDK9 IPs, and there was no detectable CDK9 in anti-CDK8 or CDK7 IPs, but small quan- tities of CDK7 were detectable by the ...
10
Optimization of luminescent assay for screening of cyclin-dependent kinase 2 inhibitors
... compromised. Cyclin-dependent kinases ensure the tight regulation of the cell cycle execution by mediating phosphorylation of cellular ...the cyclin-dependent kinase 2 activity by ...
5