Cyclin-dependent kinase 9
Down-regulating cyclin-dependent kinase 9 of alloreactive CD4 T cells prolongs allograft survival
... (Cyclin-dependent kinase 9)/Cyclin T1/RNA polymerase II pathway has been demonstrated to promote the development of several inflammatory diseases, such as arthritis or atherosclerosis, ...
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The efficacy of a cyclin dependent kinase 9 (CDK9) inhibitor, FIT039, on verruca vulgaris: study protocol for a randomized controlled trial
... requires cyclin dependent kinase 9 (CDK9) in the host cells, and that FIT039, a specific inhibitor of CDK9, suppressed the proliferation of DNA viruses such as herpes simplex virus 1 (HSV-1), ...
8
Inhibition of cyclin dependent kinase 9 by dinaciclib suppresses cyclin B1 expression and tumor growth in triple negative breast cancer
... of cyclin B1, cMYC and ...the kinase subunit of positive transcription elongation factor b (P-TEFb), instead of CDK1 or CDK2, reduced the levels of cyclin B1 and MYC in TNBC cell ...
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Influenza Virus Infection, Interferon Response, Viral Counter-Response and Apoptosis
... CDK9: cyclin-dependent kinase 9; ANP32A: acidic leucine-rich nuclear phosphoprotein 32 family member A; pol II: DNA-directed RNA polymerase 2; PTBP1: polypyrimidine tract-binding protein 1; ...
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Penta O galloyl β D glucose induces G1arrest and DNA replicative S phase arrest independently of P21 cyclin dependent kinase inhibitor 1A, P27 cyclin dependent kinase inhibitor 1B and P53 in human breast cancer cells and is orally active against triple negative xenograft growth
... chain 3 [LC3] to a faster moving LC3-II form on elec- trophoresis) by PGG of p53-null, PTEN-null, (high AKT) PC-3 PCa cells, which did not undergo caspase- mediated apoptosis after exposure to PGG [8]. We have also ...
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Cyclin-dependent kinase 2 is an ideal target for ovary tumors with elevated cyclin E1 expression
... Consistent with published immunohistochemistry studies [7, 9, 24], we showed that over 40% of primary ovary tumor specimens were positive for CCNE1 staining (Table 1 and Figure 2). Although CCNE1 staining was ...
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Downregulation of cyclin dependent kinase 2 activity and cyclin A promoter activity in vascular smooth muscle cells by p27(KIP1), an inhibitor of neointima formation in the rat carotid artery
... PAC1 cells were transiently transfected using Lipofectamine re- agent as recommended by the manufacturer (GIBCO Laboratories, Grand Island, NY). Reporter vectors containing the 2 356 to 1 109 c-fos and 2 79 to 1 100 ...
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Regulation of the G1-S transition by cyclin-dependent kinase inhibitors
... p18 Ink4c induces expression of other cdk inhibitors, specifically p16 Ink4a in a tissue specific fashion in vivo. It is possible that changes in cdk inhibitor levels could be a non-cell autonomous effect due increased ...
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Do novo del(9)(p13) in a childhood T-cell prolymphocytic leukemia as sole abnormality
... T-cell prolymphocytic leukemia (T-PLL) is a rare and aggressive subtype of chronic lymphocytic leukemia. Usually it presents in older people with a median age of 61 years. T-PLL is characterized by elevated white blood ...
5
Cyclin-Dependent Kinase Inhibitor AT7519 as a Potential Drug for MYCN-Dependent Neuroblastoma.
... The work presented here describes the preclinical evaluation of the novel fragment-derived small molecule CDK inhibitor AT7519 in neuroblastoma treatment. In agreement with our previous results, the sensitivity of ...
22
Cyclin-dependent kinase 4 is a preclinical target for diet-induced obesity
... Hypothalamus-specific deletion of LepR induces the same degree of obesity as db/db mice, which globally lack LepR function (3). Thus, leptin action deficits in the hypothalamus alone are sufficient to cause obesity, ...
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Retroviral Cyclin Enhances Cyclin-Dependent Kinase-8 Activity
... encoding cyclin C is frequently lost, and cell lines derived from these tumors are dependent upon continued cyclin C depletion for growth ...of cyclin C depletion with cancer points to a pos- ...
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Cyclin dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis
... Future studies are needed to determine whether efferocytosis can be induced as a means to slow plaque growth or potentially stimulate regression of the necrotic core. The fact that the simple application of exogenous ...
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The cyclin-dependent kinase PITSLRE/CDK11 is required for successful autophagy
... Drosophila cyclin- dependent kinase PITSLRE is a modulator of ...this kinase represents a novel phylogenetically conserved component of the autophagy ...
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Candida albicans Cyclin Clb4 Carries S-Phase Cyclin Activity
... Cdc28/Cdk1 cyclin se- quences as ...Cdk1 cyclin sequences from 13 additional published fungal genomes in order to reduce the chance of missing sequences and to increase the alignment ...
9
Cyclin dependent kinase 12, a novel drug target for visceral leishmaniasis
... Extended Data Table 6: Sensitivity of WT and compound 5-resistant intramacrophage amastigotes INMAC to the compound series... Host cell pXC50..[r] ...
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Optimization of luminescent assay for screening of cyclin-dependent kinase 2 inhibitors
... Reactions were performed with reaction mixture containing serially diluted CDK2/cyclin A (0.976, 1.953, 3.906, 7.812, 15.62, 31.25, 62.5, 125, 250, 500 ng/well), histone H1 (10 mg/ml), 100 μM ATP, ADB (5 μl), 25 ...
5
Overexpression of p53 activated by small activating RNA suppresses the growth of human prostate cancer cells
... USA), Cyclin D1 (1:1,000), CDK4 (1:1,000), CDK6 (1:500) (all Affinity, Cincinnati, OH, USA), glyceraldehyde 3-phosphate dehy- drogenase (1:1,000), and α -tubulin (1:500) (both ...
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Pharmacokinetics and biodistribution of the cyclin-dependent kinase inhibitor -CR8- in mice
... cell death induction. The drug passes the BBB at a level sufficient to reach concentrations able to inhibit neur- onal kinase targets. Bone marrow exposure was about 30% of that found as systemic exposure, a ...
9
Retroviral Cyclin Controls Cyclin-Dependent Kinase 8-Mediated Transcription Elongation and Reinitiation
... exogenous cyclin C. Ob- viously, increased levels of a CDK8-activating cyclin, whether RV- cyclin or cyclin C, can increase the output of IEG ...RV- cyclin expression will always be ...
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