Cyclooxygenase Inhibitors
Reversal of High dietary fructose-induced PPARα suppression by oral administration of lipoxygenase/cyclooxygenase inhibitors
... HMG-CoA inhibitors, which reduce serum triglycerides in these animals, also elevate/restore hepatic PPAR α ...lipoxygenase/cyclooxygenase inhibitors reversed diet-induced hypertriglyceridemia in this ...
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Prostaglandin levels in seminal plasma and sperm extracts of the domestic turkey, and the effects of cyclooxygenase inhibitors on sperm mobility
... inhibitors of both COX-1 and COX-2 produced the same degree of inhibition, even at the concentration of 0.1 mM, a level at which the COX-2 inhibitor was reported to have no inhibitory effect on COX-1 activity ...
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Cyclooxygenase inhibitors potentiate receptor tyrosine kinase therapies in bladder cancer cells in vitro
... media and allowed to attach for 24 hours. The cells were then treated with or without serum, with drugs in a dose- dependent manner alone, or in combinations for 24 hours as mentioned in figure legends. After treatments, ...
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Modulation of CXCR3 ligand secretion by prostaglandin E2 and cyclooxygenase inhibitors in human breast cancer
... inhibits IFN-g induced CXCL9 and CXCL10 secretion from breast cancer cells and that, conversely, the COX inhibitors acetylsalicylic acid (ASA) and indomethacin augment this release. Inverse correlation of COX ...
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Synthesis and anti-inflammatory activity of some new thiadiazole linked pyrazole benzene sulphonamides as cyclooxygenase inhibitors
... A new series of thiadiazole linked pyrazole benzenesulfonamide derivatives were synthesized by the condensation of aldehydic pyrazole with aryl substituted thiadiazole amine followed by Schiff base reaction. The ...
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Effects of cyclooxygenase inhibitors on the alterations in lung mechanics caused by endotoxemia in the unanesthetized sheep
... metabolism as mediators of the endotoxin-induced alterations in lung mechanics was investigated by studying sheep before and after cyclooxygenase inhibition with sodium meclofenamate and ibuprofen. Sheep were ...
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Prediction of the potency of mammalian cyclooxygenase inhibitors with ensemble proteochemometric modeling
... kidney failure and gastrointestinal side-effects, such as peptic ulcer, have been correlated to long-term intake of NSAIDs [3]. Until 1991, only one form of the enzyme (COX-1) was thought to be responsible for both the ...
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Design, synthesis and biological evaluation of benzoxazole derivatives as cyclooxygenase inhibitors
... have been investigated extensively as COX-2 inhibitors since the description of the 2,3- diarylthiophene, DuP 697, as a nonulcerogenic anti-inflammatory agent [12]. In addition 2-Oxo- 3H-benzoxazole derivatives ...
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Cyclooxygenase Inhibitors Affect Recovery of Ischemic-injured Jejunum
... Mucosal samples of ischemic-injured and non-ischemic jejunum, from the group of 6 horses that were not recovered, were taken immediately after the 2h period of ischemia. Mucosal samples from ischemic-injured and ...
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The role of cyclooxygenase inhibitors in lipopolysaccharide induced hypophagia in chicken
... that cyclooxygenase 1 (COX) enzyme has an important role in lipopoly- saccharide (LPS)-induced hypophagia in mammals but the effect of COX on LPS-induced hypophagia has not been studied in avian ...non-selective ...
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Effects of DNA and prostaglandin synthesis inhibitors on the stimulation of bone resorption by epidermal growth factor in fetal rat long bone cultures
... indomethacin, did not alter the resorptive responses of unstimulated or PTH-treated cultures in either the presence or absence of HU or the resorptive response of bones cultured with EGF alone. However, indomethacin ...
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Oxygen metabolites stimulate thromboxane production and vasoconstriction in isolated saline perfused rabbit lungs
... with cyclooxygenase inhibitors, either aspirin or indomethacin, also completely blocked thromboxane generation and markedly attenuated pressor responses usually seen after purine plus xanthine oxidase ...
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Virtual screening of natural and synthetic inhibitors of cyclooxygenase COX-2 enzyme using docking-scoring functions
... and inhibitors Download of COX-2 was done from PROTEIN DATA BANK (code 4PH9) with the three-dimensional structure obtained by X-ray diffraction (resolution ...of inhibitors were downloaded from the PubChem ...
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Non steroidal anti inflammatory drugs, Cyclooxygenase 2 inhibitors and paracetamol use in Queensland and in the whole of Australia
... (COX-2 inhibitors) were developed to inhibit mainly the 'inducible' cyclo- oxygenase associated with inflammation, cyclo-oxygen- ase-2 (COX-2) ...COX-2 inhibitors, were made available in Australia. COX-2 ...
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Anti inflammatory effects of Polygonum minus (Huds) extract (Lineminus™) in in vitro enzyme assays and carrageenan induced paw edema
... damage. Cyclooxygenase-1(COX-1) and 5-lipooxygenase (5-LOX) are key enzymes involved in the formation of pro-inflammatory mediators such as eicosanoids from AA ...
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In Vitro Interaction of Cyclooxygenase-2 Inhibitors with Radiation in Nasopharyngeal Carcinoma Cell line: Dependence on Sequence of Administration
... For the combination of coX-2 inhibitors with radiation, similarly, cells were exposed to sc-236 (50 uM), ns-398 (80 uM) or dMso (0.25% for sc-236; 0.2% for ns-398) for 24 hours before or after irradiation. single ...
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Comparison of benefit–risk preferences of patients and physicians regarding cyclooxygenase-2 inhibitors using discrete choice experiments
... Cox-2 inhibitors as treatments for arthritis, leading to several meaningful ...Cox-2 inhibitors, such as PAI and FUN, than with the risk of GI and CV adverse events, whereas physicians considered CV adverse ...
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Synthesis, Cyclooxygenase Inhibition, Anti inflammatory Evaluation and Gastric Liability of Some Novel Indole Derivatives as Selective COX 2 Inhibitors
... A new group of (4-substitutedphenyl)(3-((2-(4-substitutedphenyl)hydrazono)methyl)-1H-indol-1-yl)-methanone derivatives 13a-f as indomethacin analogs was synthesized through N-benzoylation of indole-3-cabaldehyde with the ...
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Induction of cyclooxygenase 2 in human umbilical vein endothelial cells by lysophosphatidylcholine
... induces cyclooxygenase-2 mRNA and protein ...of cyclooxygenase-2 is accompanied by the enhancement of both basal- and calcium ionophore A23187-induced synthesis of ...the cyclooxygenase-2 gene by ...
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Cyclooxygenase-2 in Endometriosis
... COX-2 is an essential therapeutic target for anti-inflammatory drugs, which are known as nonsteroidal anti-inflammatory drugs (NSAIDs), including naproxen and diclofenac, as well as newer COX-2 selective ...
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