Cyclosporine A
Cyclosporine A for the Treatment of New-Onset Insulin-Dependent Diabetes Mellitus
... Our data indicate that 4 months of cyclosporine A treatment was not enough to have an effect on the incidence of clinical remissions, C-peptide pro- duction, insulin dosage, or HbA, leve[r] ...
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Oral cyclosporine A - the current picture of its liposomal and other delivery systems
... of cyclosporine A was a milestone in organ transplantation and the treatment of autoimmune ...of cyclosporine A in the context of the physicochemical properties of the drug and the character of its ...
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<p>A Review of Topical Cyclosporine A Formulations—A Disease-Modifying Agent for Keratoconjunctivitis Sicca</p>
... Cyclosporine A is a cyclic polypeptide and a widely used immunosuppressant, with inhibitory action of both cell- mediated and humoral immunity. 9 Systemic CsA is indi- cated to prevent graft rejection and treat ...
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Cyclosporine A and steroid therapy in childhood steroid-resistant nephrotic syndrome
... The management of steroid-resistant nephrotic syndrome (SRNS) remains a clinical problem. Several treatment modalities have been tested, including high- dose corticosteroids, cyclophosphamide, cyclosporine A ...
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<p>Cyclosporine-A-Based Immunosuppressive Therapy-Induced Neurotoxicity: A Case Report</p>
... Cyclosporine-A (CsA) is a potent immunosuppressive drug for organ transplanta- tion that is capable of prolonging patient survival compared with other former immunosuppressants. 1 The administration of CsA reduces ...
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Sensitization of Candida albicans biofilms to various antifungal drugs by cyclosporine A
... studies are available which have discussed efficacy of drug combinations against biofilm growth of C. albicans [14]. Interestingly, results of combination against plank- tonic cells may not always match with that of the ...
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Clonal Cytophagic Histiocytic Panniculitis in Children May Be Cured by Cyclosporine A
... under cyclosporine and predni- sone, whereas most cases of SPLT may be best treated with more aggressive ...phocytes. Cyclosporine A treatment resulted in the complete remission of cutaneous and systemic ...
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Enhanced oral bioavailability of cyclosporine A by liposomes containing a bile salt
... Abstract: The main purpose of this study was to evaluate liposomes containing a bile salt, sodium deoxycholate (SDC), as oral drug delivery systems to enhance the oral bioavailability of the poorly water-soluble and ...
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Lipid nanoparticles for cyclosporine A administration: development, characterization, and in vitro evaluation of their immunosuppression activity
... Abstract: Cyclosporine A (CsA) is an immunosuppressant commonly used in transplantation for prevention of organ rejection as well as in the treatment of several autoimmune ...
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Original Article Association between the CYP3A4 *18B polymorphism and pharmacokinetics of cyclosporine-A in recipients of kidney transplantation in Chinese patients: a meta-analysis of observational studies
... Abstract: Purpose: The mutation frequency of the CYP3A4 *18B genetic polymorphism is relatively high in Asian populations. The influence of this polymorphism on the pharmacokinetics of cyclosporine A (CsA) is ...
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Eicosapentaenoic Acid Blocks Cyclosporine A-Induced Pancreatic Dysfunction but not Immunosuppression
... Cyclosporine A (CsA) is a widely used immunosuppressant in transplantation medicine. However, it has oxidative stress-induced side effects, including nephrotoxicity, hypertension, dyslipidemia, and glucose ...
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Limited efficacy of adalimumab in the acute phase of serpiginous choroiditis refractory to corticosteroid and cyclosporine, a case report
... Case presentation: An 18-year-old woman presented with severe vision loss in both eyes. A fundus examination revealed a foveal grayish-white lesion, and optical coherence tomography revealed outer retinal damage. She was ...
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Cyclosporine A micellar delivery system for dry eyes
... topical administration of AS, which antagonizes all types of muscarinic receptors, rapidly induces typical dry-eye symptoms. 22,25 Hence, bilateral eyes in rabbits were t[r] ...
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Tumor growth effects of rapamycin on human biliary tract cancer cells
... Initially, cells were plated in six-well plates (approxi- mately 10 5 cells per well in 5 mL culture medium). After 24 hours, cells were treated with vehicle or different concentrations of immunosuppressants (rapamycin: ...
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Cyclophilins: The Structure and Functions of an Important Peptidyl-prolyl Isomerase
... Cyclophilins can act as foldases or chaperones. They possess peptidyl-prolyl isomerases (PPIase) activity, which is inhibited by cyclosporine A (CsA). Their PPIase activity makes them be able to accelerate protein ...
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Cyclosporine and Hepatitis C
... of cyclosporine survival rates increased to more than ...(IL-4). Cyclosporine A was first iso- lated from the fungus Tolypocladium inflatum and has powerful immunosuppressive ...
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The mineralocorticoid receptor antagonist eplerenone reduces renal interstitial fibrosis after long-term cyclosporine treatment in rat: antagonizing cyclosporine nephrotoxicity
... Stereological quantitation of the volume fraction (Vv) of tubules in renal cortex of rats receiving 12 weeks of treatment with cyclosporine A (n=8) or cyclosporine A in combination with [r] ...
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Immunomodulatory Effects of Terminalia Arjuna in Fish Model
... 4 Cyclosporine exposure on renal dysfunction after cardiac transplantation, two large studies demonstrated that no relationship between cyclosporine concentration and the decline in renal function measured ...
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Disease Modifying Anti-rheumatic Drugs (DMARDs)
... 20. Mouy R, Stephan JL, Pillet P, Haddad E, Hubert P, Prieur AM. Efficacy of cyclosporine A in the treatment of macrophage activation syndrome in juvenile arthritis: report of five cases. The Journal of pediatrics ...
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Arginine feeding modifies cyclosporine nephrotoxicity in rats
... (NO). Cyclosporine A (CsA) nephrotoxicity is characterized by preglomerular vasoconstriction and decreased efferent arteriolar tone probably related to reduced NO and angiotensin II, ...
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