CYNOMOLGUS MACAQUES
Pathogenicity of Simian-Human Immunodeficiency Virus SHIV-89.6P and SIVmac Is Attenuated in Cynomolgus Macaques and Associated with Early T-Lymphocyte Responses
... rhesus macaques (Macaca mulatta), little is known about lentiviral pathogenicity and control of virus repli- cation following infection of alternative macaque ...in cynomolgus (Macaca fascicularis) and ...
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Experimental Infection of Cynomolgus Macaques (Macaca fascicularis) with Human Varicella-Zoster Virus
... of cynomolgus macaques (Macaca fascicularis) as a nonhuman primate model to evaluate VZV-based sim- ian immunodeficiency virus/human immunodeficiency virus (SIV/HIV) vaccines, we experimentally inoculated ...
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Simian Immunodeficiency Virus SIVmac239 Infection of Major Histocompatibility Complex-Identical Cynomolgus Macaques from Mauritius
... (SIV)-susceptible cynomolgus macaques (Macaca fascicularis) from the Indian Ocean island of Mauritius have extremely simple MHC genetics, with six common haplotypes accounting for two-thirds of the MHC ...
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Chikungunya virus infection in Cynomolgus macaques following Intradermal and aerosol exposure
... In humans, productive CHIKV infection can lead to fever and viremia lasting up to 1 week. Myalgia, polyar- thritis, and polyarthralgia are also commonly observed in infected individuals, with debilitating polyarthralgia ...
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Changes in Soluble Factor-Mediated CD8+ Cell-Derived Antiviral Activity in Cynomolgus Macaques Infected with Simian Immunodeficiency Virus SIVmac251: Relationship to Biological Markers of Progression
... SIVmac-infected macaques to suppress the replication of human and simian immunodeficiency viruses in vitro depends on the clinical stage of disease, but little is known about changes in this antiviral activity ...
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Sequence of Pathogenic Events in Cynomolgus Macaques Infected with Aerosolized Monkeypox Virus
... To evaluate new vaccines when human efficacy studies are not possible, the FDA’s “Animal Rule” requires well-characterized models of infection. Thus, in the present study, the early pathogenic events of monkeypox ...
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Mauritian Cynomolgus Macaques Share Two Exceptionally Common Major Histocompatibility Complex Class I Alleles That Restrict Simian Immunodeficiency Virus-Specific CD8+ T Cells
... SIVmac-infected cynomolgus macaques compared to rhesus macaques (36, ...through cynomolgus macaques could generate a more pathogenic strain (9), recapitulating the key features of ...
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Vaccination with live attenuated simian immunodeficiency virus causes dynamic changes in intestinal CD4+CCR5+ T cells
... naive cynomolgus macaques compared with Indian rhesus macaques, where the level of CCR5 expression by CD4+ intestinal T cells is reported to be >60% ...in macaques of different species ...
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Cigarette smoke and HIV synergistically affect lung pathology in cynomolgus macaques
... In the era of combined antiretroviral therapy (cART), lung diseases such as chronic bronchitis (CB) and chronic obstructive pulmonary disease (COPD) are common among persons living with HIV (PLWH), particularly smokers. ...
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Aerosolized Rift Valley Fever Virus Causes Fatal Encephalitis in African Green Monkeys and Common Marmosets
... adult cynomolgus macaques (Macaca fascicularis), rhesus macaques (Macaca mulatta, of Chinese origin), Afri- can green monkeys (AGM) (Chlorocebus aethiops), and common marmo- sets (Callithrix jacchus) ...
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Impact of Viral Dose and Major Histocompatibility Complex Class IB Haplotype on Viral Outcome in Mauritian Cynomolgus Monkeys Vaccinated with Tat upon Challenge with Simian/Human Immunodeficiency Virus SHIV89.6P
... MHC-encoded host factors, including immune response genes, contribute importantly to susceptibility to human im- munodeficiency virus (HIV)/SIV infection and progression (1, 7, 19), confounding the interpretation of ...
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Heterologous protection elicited by candidate monomeric recombinant HIV 1 gp120 vaccine in the absence of cross neutralising antibodies in a macaque model
... immunised cynomolgus macaques G19 and G21 group G), isolated from the heparinised blood by Percoll density gradient separation (GE Healthcare Bio- Sciences AB, Uppsala, Sweden), were resuspended in RPMI ...
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Immune Mediated Systemic Vasculitis as the Proposed Cause of Sudden Onset Sensorineural Hearing Loss following Lassa Virus Exposure in Cynomolgus Macaques
... of cynomolgus macaques. To determine whether macaques sur- viving LASV infection develop deafness, we experimentally infected 10 cynomolgus macaques and observed them for 45 ...All ...
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Comparative Analysis of Monkeypox Virus Infection of Cynomolgus Macaques by the Intravenous or Intrabronchial Inoculation Route
... Monkeypox virus (MPXV) is a member of the genus Or- thopoxvirus, which includes variola (VARV), cowpox, vaccinia, and camelpox viruses. MPXV was first isolated in 1958 in Denmark from an imported cynomolgus ...
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Disease Severity Is Associated with Differential Gene Expression at the Early and Late Phases of Infection in Nonhuman Primates Infected with Different H5N1 Highly Pathogenic Avian Influenza Viruses
... of macaques infected with different H5N1 viruses isolated from ...three cynomolgus macaques with one of six H5N1 influenza virus strains (Table ...
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Influenza Virus A/Anhui/1/2013 (H7N9) Replicates Efficiently in the Upper and Lower Respiratory Tracts of Cynomolgus Macaques
... in macaques in our study was similar to that de- scribed previously ...of cynomolgus macaques with seasonal H3N2 influenza A virus resulted in infec- tion with mild or even asymptomatic disease (48, ...
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Pathogenesis of Influenza A (H5N1) Virus Infection in a Primate Model
... Forty-eight cynomolgus macaques had been infected by the intratracheal route with cell culture-passaged influenza virus A/Netherlands/18/94 (H3N2) with a dose 400 times higher than the dose of A/HK/156/97 ...
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Assessment of the Protective Effect of Imvamune and Acam2000 Vaccines against Aerosolized Monkeypox Virus in Cynomolgus Macaques
... Imvamune is a more recent smallpox vaccine and is being fast- tracked by the FDA for use in humans (37). This vaccine is cur- rently stockpiled in the United States for use during an emergency, such as an imminent ...
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Wild-Type Puumala Hantavirus Infection Induces Cytokines, C-Reactive Protein, Creatinine, and Nitric Oxide in Cynomolgus Macaques
... of cynomolgus macaques by wild-type Puumala hantavirus resulted in typical signs of HFRS including lethargy, anorexia, proteinuria, and/or hematuria, in addition to cytokine (interleukin 6 [IL-6], IL-10, ...
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Blood genomic profiles of exposures to Venezuelan equine encephalitis in Cynomolgus macaques (Macaca fascicularis)
... A total of 11 captive-born, adult male cynomolgus mon- keys were used in this study. Research was conducted in compliance with the Animal Welfare Act and other federal statutes and regulations relating to animals ...
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