Cyr61/CCN1
CYR61 (CCN1) is a metastatic biomarker of gastric cardia adenocarcinoma
... 37]. CYR61 promotes tumor angiogenesis through alphav/beta3 integrin-mediated cell adhesion and stimulates neo-vascularization ...observed CYR61 activates the Wnt/ Catenin, the Sonic Hedgehog (SHh), the ...
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Original Article Cyr61 overexpression induced by interleukin 8 via NF-kB signaling pathway and its role in tumorigenesis of gastric carcinoma in vitro
... Abstract: Cyr61 (CCN1) is a multifunctional matricellular protein in bridging inflammation and cancer, involved in many biological functions such as tumorigenesis and ...of Cyr61 in gastric cancer ...
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Comparable response of ccn1 with ccn2 genes upon arthritis: An in vitro evaluation with a human chondrocytic cell line stimulated by a set of cytokines
... members: Cyr61 (CCN1), CTGF (CCN2), Nov (CCN3), Elm-1/WISP-1 (CCN4), rCop-1/WISP-2/CTGF-L (CCN5), and WISP-3 (CCN6) ...[12,13]. CCN1 and CCN2 can stimulate chemo- taxis and promote proliferation of ...
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Coxsackievirus B3 Infection Induces cyr61 Activation via JNK To Mediate Cell Death
... that cyr61, a gene encoding cysteine-rich protein 61 (Cyr61), was gradually ...analysis. cyr61 is an im- mediate-early gene and is one member of the CCN family, which comprises ...
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Exercise-induced expression of angiogenic growth factors in skeletal muscle and in capillaries of healthy and diabetic mice
... of Cyr61 was also increased in diabetic muscles. Cyr61 (also known as CCN1) is an important regulator of angiogenesis, endothelial cell function and ECM modulation ...of Cyr61 and connective ...
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MicroRNA-181c inhibits cigarette smoke–induced chronic obstructive pulmonary disease by regulating CCN1 expression
... as Cyr61, GIG1, or IGFBP10, belongs to the CCN protein ...that CCN1 promotes the adhesion of endothelial cells, interacts with several integrins and with heparan sulfate proteoglycan, and plays a role in ...
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A structural approach to the role of CCN (CYR61/CTGF/NOV) proteins in tumourigenesis
... of CCN1, CCN2, and CCN4, but not CCN3 were associated with more advanced features ...Increased CCN1 pro- tein expression was observed in a large number of primary breast tumours that were progesterone ...
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CCN1 induces hepatic ductular reaction through integrin αvβ5–mediated activation of NF κB
... that CCN1 (also known as CYR61), a matricellular protein that dampens and resolves liver fibrosis, also mediates cholangiocyte proliferation and ductular reaction, which are repair responses to cholestatic ...
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Eyeing the Cyr61/CTGF/NOV (CCN) group of genes in development and diseases: highlights of their structural likenesses and functional dissimilarities
... development, CCN1 is widely expressed in the cardiovascular system ...of CCN1 was seen as early as ...ous Cyr61 promoter. CCN1 expression continued at ...[16]. CCN1 expression was also ...
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Transplantation of human endometrial perivascular cells with elevated CYR61 expression induces angiogenesis and promotes repair of a full-thickness uterine injury in rat
... albumin; CCN1: CCN family member 1; CTGF: Connective tissue growth factor; CYR61: Cysteine-rich angiogenic inducer 61; DAPI: 4 ′ ,6-Diamidino-2-phenylindole; ECM: Extracellular matrix; eMSC: Endometrial ...
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Cyr61 as mediator of Src signaling in triple negative breast cancer cells
... For CCN1 (Cyr61) qRT-PCR was performed using SYBR Green Master Mix (Life ...for Cyr61 and GAPDH, used as endogenous control, were previously described ...
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Cysteine rich 61 (Cyr61): a biomarker reflecting disease activity in rheumatoid arthritis
... called CCN1), a novel se- creted matricellular protein, is encoded by a growth factor-inducible immediate-early ...gene. Cyr61 expression is at low levels in most adult tissues under homeostatic conditions, ...
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Mesenchymal stem cell contact promotes CCN1 splicing and transcription in myeloma cells
... proteins; CCN1: CCN family member 1; CCN2: CCN family member 2; CCN3: CCN family member 3; CDS: Coding sequence; CM: Conditioned media; CT: Carboxy-terminal domain; CTGF: Connective tissue growth factor; ...
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Cyr61-positive cancer stem-like cells enhances distal metastases of pancreatic cancer
... [23–25]. Cyr61 has been shown to be involved in the regulation of a number of signaling pathways, and thus its biological function is ...of Cyr61 has been found in different cancers, and is associated with ...
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The m6A demethylase ALKBH5 controls trophoblast invasion at the maternal-fetal interface by regulating the stability of CYR61 mRNA
... ALKBH5 RNA demethylase belongs to the AlkB subfamily of the Fe (II)/2-oxoglutarate (2OG) dioxygenase superfamily and is primarily localized in the nucleus. This enzyme is upregulated under hypoxic conditions by the ...
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ETV5 links the FGFR3 and Hippo signalling pathways in bladder cancer
... information on FGFR3 mutation status is available, no significant difference in ETV5 expression was observed between mutant and wild type tumours. This is not surprising as we have shown that ETV5 expression is modu- ...
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Cyr61 and YB-1 are novel interacting partners of uPAR and elevate the malignancy of triple-negative breast cancer
... To visualize and quantify the complex formation of uPAR with interactors, the PLA was performed on sections of cell line blocks and of the TMA blocks using the DUOLink™ kit (OLINK Bioscience, Uppsala, S) according to the ...
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ATF3 inhibits the tumorigenesis and progression of hepatocellular carcinoma cells via upregulation of CYR61 expression
... regulate CYR61, the JASPAR ...the CYR61 sequence ...on CYR61 sequence (+ 349 to + 504 bp) and found that the relative luciferase activity of these truncated se- quences was significantly increased ...
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The mechanism of CCN1-enhanced retinal neovascularization in oxygen-induced retinopathy through PI3K/Akt–VEGF signaling pathway
... study, CCN1 siRNA intravitreal injection efficiently inhibited retinal angiogenesis by reducing VEGF mRNA and protein ...that CCN1 depletion can exert an anti-angiogenic effect by decreasing VEGF ...of ...
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Hypoxic stabilization of mRNA is HIF-independent but requires mtROS
... and CYR61 mRNA and resulted in a moderate level of HIF-1α protein stabilization and an increase in GLUT1(a known HIF transcriptional target) protein levels as compared to the loading control ...or CYR61 ...
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