Cysteinyl-Leukotriene
FTY720 stimulates multidrug transporter– and cysteinyl leukotriene–dependent T cell chemotaxis to lymph nodes
... A recent report demonstrates that FTY720 becomes phosphorylated in vivo and then acts as a potent ago- nist for multiple sphingosine-1-phosphate (S1P) recep- tors (S1PRs) (6). S1PR activation seems responsible for ...
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Transforming growth factor β1-induced astrocyte migration is mediated in part by activating 5-lipoxygenase and cysteinyl leukotriene receptor 1
... It is also reported that 5-lipoxygenase (5-LOX) and its products, cysteinyl leukotrienes (CysLTs, namely LTC 4 , LTD 4 and LTE 4 ), as well as cysteinyl leukotriene receptor 1 (CysLT 1 R[r] ...
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Original Article Expression of cysteinyl leukotriene receptor in brain tissues of rats with Streptococcus pneumoniae meningitis
... inyl leukotriene receptor (CysLTR) participates in the inflammatory response and elucidates the pathologic process of ...proliferation. Cysteinyl leukotriene receptors could, therefore, be novel ...
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Cysteinyl leukotriene correlated with 8-isoprostane levels as predictive biomarkers for sensory dysfunction in autism
... [26–28]. Cysteinyl leukotri- enes (CysLTs) as biologically active lipid mediators play a key role in mediating inflammation and involved in pathological states with an inflammatory ...
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Cysteinyl Leukotrienes Mediate Histamine Hypersensitivity Ex Vivo by Increasing Histamine Receptor Numbers
... Mouse macrophages, primary isolated human peripheral blood monocytes, and human umbilical smooth muscle cells were investigated before and after cysteinyl leukotriene stimulation.. Resul[r] ...
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Regulation of human airway smooth muscle cell migration and relevance to asthma
... cognate receptor; ASM: Airway smooth muscle; ASMCs: Airway smooth muscle cells; ATRA: All-trans retinoic acid; cAMP: Cyclic adenosine monophosphate; CysLTR: Cysteinyl leukotriene recepto[r] ...
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The complex pathophysiology of allergic rhinitis: scientific rationale for the development of an alternative treatment option
... CysLT: cysteinyl leukotriene; EU: European Union; FP: fluticasone propionate; GM-CSF: granulocyte macrophage colony-stimulating factor; ICAM-1: intercellular adhesion molecule-1; IgE: immunoglobulin E; IL: ...
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Synthesis of tenascin and laminin beta2 chain in human bronchial epithelial cells is enhanced by cysteinyl leukotrienes via CysLT1 receptor
... Analysis of cysteinyl leukotriene receptors CysLT 1 and CysLT 2 in BEAS-2B human bronchial epithelial cells Figure 4. Analysis of cysteinyl leukotriene receptors CysLT 1 and CysLT 2 [r] ...
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Leukotriene receptors as potential therapeutic targets
... and cysteinyl leukotriene receptor 1 (CysLT 1 ) antagonists are market- ed to treat bronchial asthma and allergic rhinitis, other targets for at least four distinct types of receptors or their combinations ...
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Receptor Identification: Advances in Ligands and Transmitters Discovery
... out cysteinyl leukotriene CysLT1 and Cys T2, hepatointestinal leukotriene B4, motilin, Ghrelin, Growth hormone-releasing peptide and growth hormone secretagogue receptor and many ...
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Preparation and in vitro Evaluation of Fast Disintegrating Tablets of BCS Class II Drug
... the cysteinyl leukotriene receptors, inhibiting binding at the cysteinyl leukotriene type 1 receptor, having absolute bioavailability of approximately ...
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Lipid mediators in plasma of autism spectrum disorders
... PGE2, cysteinyl leukotriene and 8-isoprostane in plasma of autistic patients in a trial to investigate the role of these lipid mediators related to AA and Phospholipids (PS, PC and PE) in the pathology of ...
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Caspase-11, a specific sensor for intracellular lipopolysaccharide recognition, mediates the non-canonical inflammatory pathway of pyroptosis
... pathways, cysteinyl aspartate specific proteinase (cas- pase)-1 induced canonical inflammatory pathway and caspase-11 induced non-canonical inflammatory path- way, have been suggested to regulate pyroptosis ...
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Location and Role of Free Cysteinyl Residues in the Sindbis Virus E1 and E2 Glycoproteins
... Location of the free Cys residues in SV E1 and E2 proteins. Mature virus particles were collected from the media of in- fected BHK cells and purified over potassium tartrate gradi- ents (as described in Materials and ...
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Synthesis and Antifungal Evaluation of Barbiturate Saponins And Progress Towards Cysteinyl Metal Peptides
... The free NH group of the thiazolidine moiety 23 is readily available for peptide coupling in both the carboxy and the ester derivatives of thiazolidine 15 and 23 respectively (Sch[r] ...
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Inhibitory effects of resveratrol on human mast cell degranulation, cytokine, chemokine and leukotriene release
... Mast cells are key mediators of allergic and anaphy- lactic responses, releasing pro-inflammatory mediators in response to allergen-crosslinking of FcεRI-bound IgE [8,9]. Resveratrol reduces airway hyperresponsiveness, ...
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Asthma control in adolescents: role of leukotriene inhibitors
... Lemanske et al randomly assigned 182 children (6–17 years of age) who suffered from uncontrolled asthma while receiving 100 µ g fluticasone twice daily to receive each of three blind stepup therapies in random order for ...
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Successful management of refractory cough with the leukotriene receptor antagonist zafirlukast in a dog with chronic bronchitis: a case report I.H. Yoon, H.J. Han, J.H. Kim*
... ABSTRACT: A 7-year-old spayed female Pomeranian dog was evaluated for a 6-month history of intractable coughing and dyspnoea. The cough was unresponsive to antibiotics and a bronchodilator medication prescribed by the ...
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Pathophysiology of nasal congestion
... Figure 1 Clinical data support a role for leukotrienes as mediators of congestion in allergic rhinitis. A ) Cysteinyl leukotrienes (cys-LT) can be recovered at elevated levels in nasal[r] ...
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Role of biomarkers in understanding and treating children with asthma: towards personalized care
... and cysteinyl leukotrienes are both promis- ing areas of study that can help personalize management, not just for pharmacologic management but also education and prevention ...
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