Cytidine deaminase
Contribution of Cytidine Deaminase to Thymidylate Biosynthesis in Trypanosoma brucei: Intracellular Localization and Properties of the Enzyme
... T rypanosoma brucei is an extracellular protozoan parasite within the Kinetoplastida order and the causative agent of African trypanosomiasis. The subspecies T. brucei rhodesiense and T. brucei gambiense are responsible ...
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7SL RNA Mediates Virion Packaging of the Antiviral Cytidine Deaminase APOBEC3G
... Cytidine deaminase APOBEC3G (A3G) has broad antiviral activity against diverse retroviruses and/or retrotransposons, and its antiviral functions are believed to rely on its encapsidation into virions in an ...
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Chemoprotection of murine hematopoietic cells by combined gene transfer of cytidine deaminase (CDD) and multidrug resistance 1 gene (MDR1)
... Multi-drug resistance 1 (MDR1) and cytidine deaminase (CDD) represent two other well-studied CTX-R genes. The human MDR1 gene encodes the cellular efflux protein ABCB1 (P-glycoprotein, P-gp), a member of ...
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Induction of activation-induced cytidine deaminase by a not-directly mutagenic carcinogen: a novel potential molecular mechanism
... activation-induced cytidine deaminase (AID) in somatic cells play a critical role in carcinogenesis [4–7], and transgenic mice with overexpression of AID are prone to tumorigenicity ...
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Original Article Activation-induced cytidine deaminase expression in colorectal cancer
... [24] Muñoz DP, Lee EL, Takayama S, Coppé JP, Heo SJ, Boffelli D, Di Noia JM and Martin DI. Activa- tion-induced cytidine deaminase (AID) is nec- essary for the epithelial-mesenchymal transi- tion in mammary ...
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Adaptive Evolution and Antiviral Activity of the Conserved Mammalian Cytidine Deaminase APOBEC3H
... APOBEC3H is a potent restriction factor likely to be im- portant in preventing lentiviral infection in vivo in certain primate species, including the rhesus macaque and sooty mangabey but likely not in humans. Despite ...
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Paclitaxel alters the expression and specific activity of deoxycytidine kinase and cytidine deaminase in non-small cell lung cancer cell lines
... 75%, the diphosphate decreased by about 87% (paclitaxel vs. vehicle control, P < 0.05) and the monophosphate decreased by about 37% in the H520 cells. The accumula- tion of the deaminated metabolite also decreased in ...
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Involvement of activation induced cytidine deaminase in skin cancer development
... occur independently of UV damage. A causal link between UV-independent skin cancers and chronic inflammation has been suspected, although the precise mechanism underlying this association is unclear. Here, we have ...
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Asymmetric Modification of Hepatitis B Virus (HBV) Genomes by an Endogenous Cytidine Deaminase inside HBV Cores Informs a Model of Reverse Transcription
... a cytidine deaminase ...the deaminase; this single-stranded region may be partially FIG 8 The pattern of cytidine deamination constrains a model of reverse ...from cytidine deamination ...
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Human APOBEC1 cytidine deaminase edits HBV DNA
... human cytidine deaminase, human APOBEC1 (hA1) first identified in 1995 has been overshadowed by other paralogs, notably activation induced cytidine deaminase (AICDA) and the APOBEC3 gene ...
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Identification of a Single Amino Acid Required for APOBEC3 Antiretroviral Cytidine Deaminase Activity
... activation-induced cytidine deaminase (AID) substrate sequence specificity via DNA bind- ing (1, 9, ...A3G cytidine deaminase activity has been experimentally shown (2, 3, 7), and the role of ...
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Purification and Properties of Cytidine Deaminase from Normal and Leukemic Granulocytes
... Cytidine deaminase, an enzyme that catalyses the deamination of both cytidine and its nucleoside analogues including the antineoplastic agents cytosine arabinoside ara-C and 5-azacytidin[r] ...
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High cytidine deaminase expression in the liver provides sanctuary for cancer cells from decitabine treatment effects
... enzyme cytidine deaminase (CDA) is a mechanism of cancer cell resistance to cytidine ...historically, cytidine analogues have not been successful chemotherapeutics against hepatotropic ...
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A Protein Antagonist of Activation Induced Cytidine Deaminase Encoded by a Complex Mouse Retrovirus
... ABSTRACT Complex human-pathogenic retroviruses cause high morbidity and mor- tality worldwide, but resist antiviral drugs and vaccine development due to evasion of the immune response. A complex retrovirus, mouse mammary ...
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Uracil DNA Glycosylase Is Dispensable for Human Immunodeficiency Virus Type 1 Replication and Does Not Contribute to the Antiviral Effects of the Cytidine Deaminase Apobec3G
... Both HIV-1 integrase (IN) and the viral accessory protein Vpr have been shown to bind to and mediate incorporation of UNG2 into the virus particle (27, 34), and the presence of UNG2 in the HIV virion has generated ...
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Genetic Analysis of the Localization of APOBEC3F to Human Immunodeficiency Virus Type 1 Virion Cores
... FIG 2 Truncation mutations in C-terminal domain of A3F decrease core localization of A3F, while A3F/A3C C-terminal chimeras maintain core local- ization, suggesting that conserved ␣ -helix 6 leucine residues play a role ...
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The Role of the CC ‐chemokine receptor 6, CCR6, in B cell differentiation during the humoral immune response
... List of Abbreviations AID: Activation-induced Cytidine Deaminase ANOVA: Analysis of Variance AP-1: Activator Protein -1 Bcl-6: B-cell lymphoma 6 BCR: B cell Receptor Blimp-1: B lymph[r] ...
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HIV 1 Vif inhibits G to A hypermutations catalyzed by virus encapsidated APOBEC3G to maintain HIV 1 infectivity
... A3G cytidine deaminase activity in a degradation- independent ...A3G-induced cytidine deamination is inhibited by the expression of Vif, without the depletion of a deaminase domain, in an ...
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Decreased frequency and activated phenotype of blood CD27 IgD IgM B lymphocytes is a permanent abnormality in systemic lupus erythematosus patients
... IgD IgM B lymphocytes in immunodeficient patients that lack GC formation and conventional switched memory B cells, indicates that the generation of the cell-subset under study can be GC-independent; hence, the IGV gene ...
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Germline APOBEC3B deletion is associated with breast cancer risk in an Asian multi ethnic cohort and with immune cell presentation
... activation-induced cytidine deaminase; APOBEC1, apolipoprotein B mRNA-editing enzyme, catalytic polypeptide 1; APOBEC2, apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 2; APOBEC3A, ...
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