cytochrome bc1
Binding Study of Cis Atovaquone with Cytochrome bc1 of Yeast
... the cytochrome bc1 was taken from protein data bank and represented “extended” atom representation where the amino, hydroxyl, methyl groups are treated as the single ...The cytochrome bc1 pro- ...
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Structure and function studies of the cytochrome bc1 complex
... native cytochrome bc1 complex, the [2Fe-2S] cluster undergoes redox state changes during the catalytic ...by cytochrome c1 as was suggested recently ...of cytochrome b speculated to be the ...
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Structure of yeast cytochrome c oxidase in a supercomplex with cytochrome bc1
... Activity measurements. Steady-state oxygen consumption rates were measured using a Clark-type oxygen electrode (Oxygraph, Hansatech), operated at 25˚C. Assays were conducted with purified protein at 15 nM, in 10 mM KPi, ...
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Visualizing changes in electron distribution in coupled chains of cytochrome bc1 by modifying barrier for electron transfer between the FeS cluster and heme c1
... © 2009 Elsevier B.V. 1. Introduction Bioenergetic enzymes use chains of cofactors to transfer electrons over long distances and connect catalytic sites with substrate redox pools. In such systems, the overall direction ...
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Mitochondrial disease-related mutations at the cytochrome b-iron–sulfur protein (ISP) interface: Molecular effects on the large-scale motion of ISP and superoxide generation studied in Rhodobacter capsulatus cytochrome bc1
... between cytochrome b and ...the cytochrome b-ISP-HD interface influence the motion of ISP-HD and indicates that “pushing” ISP-HD away from the Q o site is the most likely outcome of this ...
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Identifying involvement of Lys251/Asp252 pair in electron transfer and associated proton transfer at the quinone reduction site of Rhodobacter capsulatus cytochrome bc1
... In cytochrome bc 1 , one of the key enzymes of respiration or photosynthesis, proton transfers engage in oxidation of quinol (QH 2 ) and reduction of quinone (Q) taking place at two distinct catalytic ...
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Discrimination between two possible reaction sequences that create potential risk of generation of deleterious radicals by cytochrome bc1 Implications for the mechanism of superoxide production
... force, cytochrome bc 1 can be a source of ...of cytochrome bc 1 that severely impeded the oxidation of FeS by cytochrome c 1 , changed density of FeS around Q o by interfering with its movement, or ...
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Antimalarial drug design: targeting the plasmodium falciparum cytochrome bc1 complex through computational modelling, chemical synthesis and biological testing
... oxidoreductases, such as dihydroorotate dehydrogenase (PfDHODH) that is present within the mitochondria, and has an important role in de novo pyrimidine biosynthesis. 116 Pyrimidine biosynthesis is essential for the ...
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Protonmotive pathways and mechanisms in the cytochrome bc1 complex
... The ubiquinone head-group is oriented towards the matrix and the isoprenoid tail extends along the hydrophobic cleft Fig. 4. Putative proton uptake pathways for ubiquinone reduction at center N. Panel (a) shows two ...
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Novel cyanide inhibition at cytochrome c1 of Rhodobacter capsulatus cytochrome bc1
... similarly assembled and operating catalytic core. Within this core, the two quinol/quinone binding sites, by pro- viding an environment for catalytic chemical reactions and defining critically important, but different ...
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The dimeric structure of the cytochrome bc1 complex prevents center P inhibition by reverse reactions at center N
... of cytochrome b and cytochrome c 1 reduction at different quinol and quinone ...of cytochrome b (panel A) and cytochrome c 1 (panel B) reduction by ...of cytochrome b reduction (A) were ...
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A functional hybrid between the cytochrome bc1 complex and its physiological membrane-anchored electron acceptor cytochrome cy in Rhodobacter capsulatus
... ): cytochrome (cyt) c oxidoreductase (or the cyt bc 1 complex) and its physiological electron acceptor, the membrane-anchored cytochrome c y (cyt c y ), are discrete components of photosynthetic and ...
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Modular assembly of yeast cytochrome oxidase
... FIGURE 7: Scheme of cytochrome oxidase assembly. Newly translated Cox1p interacts with Cox14p and Coa1p to form complex D1. Cox25p/Coa3p was detected in D2, D3, D4, and COX/D5 (unpublished data). Owing to poor ...
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Role of cytochrome P450 in drug interactions
... Some drugs exhibit a significantly increased (up to three-fold) mean oral bioavailability when co-administered with grapefruit juice. Bailey et al [125] reported that the inhibitory effe[r] ...
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Cytochrome P450 Biocatalysts: A Route to Bioremediation
... In almost all living organism, these enzymes are present in more than one form, thus forming one of the largest gene super families. The presence of P450 in diverse organisms, from bacteria, fungi to plants and animal ...
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Molecular investigations of plant cytochrome P450
... ECOD inhibition with NADPH-supported activity would have been more ideal.. Microsomes prepared from pGYCYP71B7 and pGY transformed S. Control and expressing mierosomes [r] ...
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MUTANTS OF YEAST DEFICIENT IN CYTOCHROME C
... The use of strains having low frequencies of p- cells (approximately one percent) is desirable, since previous studies of mutants with altered cytochrome &ems were [r] ...
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Mapping the cytochrome c folding landscape
... Microsoft Word Appendix doc 127 Appendix 128 INTRODUCTION The ligand substitutions that occur during folding of horse heart ferrocytochrome c were investigated in our laboratory using transient absorp[.] ...
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The cytochrome bd respiratory oxygen reductases
... in L. monocytogenes [105] . In Rhodobacter capsulatus, expression of cytochrome bd is likely controlled by RegA regulator [186] . 5. Distribution and evolution The bd-family of oxygen reductases has a wide ...
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Cytochrome P450 Drug Interactions Table
... • The table contains lists of drugs in columns under the designation of specific cytochrome P450 isoforms. A drug appears in a column if there is published evidence that it is metabolized, at least in part, via ...
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