Cytochrome C Release
Bilirubin and Amyloid-β Peptide Induce Cytochrome c Release Through Mitochondrial Membrane Permeabilization
... that release of the 15 kDa caspase- activating factor occurs independently of any de- tectable mitocondrial depolarization, implying that opening of the megapore is a downstream event to caspase activation ...with ...
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Differential Regulation of Cytochrome C Release in Dexamethasone Resistant 7TD1 Cells
... cocorticoids) in order to study the progression of MM and the mechanisms responsible for resistance to gluco- corticoids including dexamethasone [40]. A study con- ducted by Rosen et al., using the MM cell lines showed ...
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The effect of amixin and agmatine on cytochrome c release from isolated mitochondria
... and cytochrome c release in the presence of apoptogenic ...suppress cytochrome c release from mouse brain and liver mitochondria stimulated with apoptogenic dose of Са 2+ and ...
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Involvement of mitochondrial swelling in cytochrome c release from mitochondria treated with calcium and Alloxan
... the release of Cyt c ...the release of Cyt c (Figure 3(b) and Table ...the release of Cyt c from mitochondria is not parallel with MPT induced by alloxan-Ca 2+ and may be ...
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Induction of apoptosis in cancer cells by NiZn ferrite nanoparticles through mitochondrial cytochrome C release
... culture plates. After incubation for 24 hours to allow cell attachment, the exponentially growing cells were exposed to NiZn ferrite nanoparticles at concentrations of 10, 50, 100, and 1000 µ g/mL. The plates were then ...
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Photoactivated fullerene C(60) induces store-operated Ca(2+) entry and cytochrome c release in Jurkat cells
... were then incubated in blocking solution (5% skim milk in PBST) for 1 h, followed by overnight in- cubation with antibody against cytochrome c (Sig- ma, USA) at a dilution of 1 : 2,500 at 4 °C. The ...
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Reovirus Infection or Ectopic Expression of Outer Capsid Protein μ1 Induces Apoptosis Independently of the Cellular Proapoptotic Proteins Bax and Bak
... as release of smac/DIABLO from the mitochondrial intermembrane space is needed to repress the activity of the cellular inhibitor of apoptosis proteins (cIAPs) to allow acti- vation of effector caspases ...induces ...
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Cathepsin B contributes to TNF α–mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c
... induce release of cytochrome c from mitochon- dria? The preceding results place cat B upstream of mitochondria in the TNF-α/AcD–induced apoptotic cascade in mouse ...inducing cytochrome ...
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A Novel Bcl-2-Like Inhibitor of Apoptosis Is Encoded by the Parapoxvirus Orf Virus
... its C-terminal, mitochondrion-targeting motif, ORFV125 shares similarities in size and a predicted compact globular structure with Bcl-2 family ...inhibits cytochrome c release, but not JNK ...
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Game and Players: Mitochondrial Apoptosis and the Therapeutic Potential of Ursodeoxycholic Acid
... as c-Myc, Ras and cell cycle regulators including cyclin-dependent kinases (CDK) and cyclins (Vermeulen et ...for c-Myc-induced apoptosis are not well understood. c-Myc-induced apoptosis may involve ...
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APOPTOSIS SIGNALING; A DRUG DESIGN IN CANCER THERAPY: A REVIEW
... of cytochrome c release), inhibitor of apoptosis proteins (IAPs) (inhibition of caspases), and second mitochondrial activator of caspases (Smac) and Omi (negative regulation of ...the release ...
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Activation of the intrinsic and extrinsic pathways in high pressure-induced apoptosis of murine erythroleukemia cells
... the release of cytochrome c from the mitochondria [4, ...released cytochrome c binds to Apaf-1 (apoptotic protease activating ...oligomeric cytochrome c-Apaf-1 complex ...
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Role of the Mitochondrial Signaling Pathway in Murine Coronavirus-Induced Oligodendrocyte Apoptosis
... WinMDI2.8. Cytochrome c release assay. The cytochrome c release apoptosis assay kit (Calbiochem; catalog ...of cytochrome c ac- cording to the manufacturer’s ...
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IMB-6G, a novel N-substituted sophoridinic acid derivative, induces endoplasmic reticulum stress-mediated apoptosis via activation of IRE1α and PERK signaling
... The release of Cytochrome c from mitochondria to cytoplasm and the translocation of Bax from cytoplasm to mitochondria are required for caspase activation that initiates the apoptotic program ...on ...
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Apoptosis associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl 2
... Smac/DIABLO release from mito- chondria is a general feature of ...apoptosis-associated release of Smac/DIABLO from mitochondria (Figures 4 and ...Whereas cytochrome c release lies ...
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Predicting effective pro apoptotic antileukaemic drug combinations using cooperative dynamic BH3 profiling
... induce cytochrome C release was documented, but no enhancement of cytochrome C release was detected when A-1210477 was used with the MCL-1 downregulating agents pladienolide B or ...
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Anticancer properties of propofol docosahexaenoate and propofol eicosapentaenoate on breast cancer cells
... and cytochrome c release (Fig. 9). Cytochrome c has a func- tion in the intrinsic pathway of apoptosis and leads to the acti- vation of caspase-3, which is a downstream enzyme in the ...
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Poliovirus Induces Bax-Dependent Cell Death Mediated by c-Jun NH2-Terminal Kinase
... translocation, cytochrome c release, and cell death following PV infection depend on JNK ...and c-Jun forms to confirm equal protein ...anti-cytochrome c (Cyt c) ...(D) ...
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Regulation of apoptosis in postmitotic cells
... Ca2+ release from the ER, seen with multiple stressors, can result in the uptake of Ca2+ by the mitochondria leading to cytochrome c release (Nutt et ...initiate cytochrome c ...
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Original Article Ulinastatin inhibits oxidant-induced endothelial hyperpermeability and apoptotic signaling
... chrome c from mitochondria, and activation of caspase 3 in association with vascular hyper- permeability [8, ...oxidant-induced cytochrome c release further shows the protective effects of ...
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