cytochrome P450s (CYPs)
Genome-wide analysis of cytochrome P450s of Trichoderma spp.: annotation and evolutionary relationships
... [45]. Cytochrome P450s are important for cells to perform a wide variety functions like primary and secondary metabolism, xenobiotic deg- radation and cellular defence ...using cytochrome ...
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Allelic Variation of Cytochrome P450s Drives Resistance to Bednet Insecticides in a Major Malaria Vector
... especially cytochrome P450s [6, 8] as the two major mechanisms conferring resistance to ...over-expressed P450s in pyrethroid resistance, the detailed molecular mechanisms through which they confer ...
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ANTIOXIDANT PROPERTIES OF GYNURA PROCUMBENS EXTRACTS AND THEIR INHIBITORY EFFECTS ON TWO MAJOR HUMAN RECOMBINANT CYTOCHROME P450S USING A HIGH THROUGHPUT LUMINESCENCE ASSAY
... Vol 7, Issue 5, 2014 ISSN 0974 2441 ANTIOXIDANT PROPERTIES OF GYNURA PROCUMBENS EXTRACTS AND THEIR INHIBITORY EFFECTS ON TWO MAJOR HUMAN RECOMBINANT CYTOCHROME P450S USING A HIGH THROUGHPUT LUMINESCEN[.] ...
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Extrahepatic cytochrome P450s play an insignificant role in triptolide-induced toxicity
... local P450s or can be generated in the liver or other tissues and then trans- ported to the target tissues by systemic circulation ...hepatic P450s suppresses TP metabolism in the liver, leading to an ...
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Changes in cytochrome P450s-mediated drug clearance in patients with hepatocellular carcinoma in vitro and in vivo : a bottom-up approach
... three drugs in liver cirrhosis had been performed [11]. Similarly, another previously attempt collected a series of parameters (e.g. CL M , V max , K m , and MPPGL) reported in the literature to predict the effects of ...
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Gene Amplification, ABC Transporters and Cytochrome P450s: Unraveling the Molecular Basis of Pyrethroid Resistance in the Dengue Vector, Aedes aegypti
... of P450s most likely represent alternative haplotypes. P450s contained within these putative duplicate clusters have been assigned independent accession numbers in VectorBase but named as allelic variants ...
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Characterizing the pregnane X receptor's interactions and biophysical properties
... The human pregnane X receptor PXR plays a important role in controlling the expression of genes central to drug and endobiotic metabolism, including those encoding cytochrome P450s (CYPs), ...
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Applications of CYP-450 expression for biomonitoring in environmental health
... During the past 30 years, biomarker-based approaches have been used in the area of human biomonitoring with the expectation of refining exposure assessment, providing tools for the detection of disease-related changes ...
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Hepatoprotective Diterpenoids Isolated from Andrographis paniculata
... The cytochrome P450 enzymes (CYPs) are known as a superfamily of haemoproteins with a unique spectrophotometric absorbance peak at 450 nm when re- duced by a reducing agent and bound by carbon monox- ide ...
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Allelic variation and multigenic metabolic activity of cytochrome P450s confer insecticide resistance in field populations of anopheles funestus s.s., a major malaria vector in Africa
... are P450s from CYP6 family and four of these genes (CYP6P9, CYP6P4, CYP6AA4 and CYP6P1) are overexpressed in pyrethroid resistant ...of P450s CYP6Z1, CYP6Z3 and ...
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Expression of the cytochrome P450s, CYP6P3 and CYP6M2 are significantly elevated in multiple pyrethroid resistant populations of Anopheles gambiae s.s. from Southern Benin and Nigeria
... The impact of pyrethroid resistance in An. gambiae from Southern Benin, believed to be driven by kdr, has been implicated in the failure of LLIN's in the region [11]. N'Guessan used biochemical analysis of the mosquitoes ...
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Transcriptomic insights into the early host pathogen interaction of cat intestine with Toxoplasma gondii
... XLSX 259 kb Abbreviations AD: Alzheimer’s disease; AIDS: Acquired immune deficiency syndrome; APOE: Apolipoprotein E; APP: Amyloid precursor protein; CYPs: Cytochrome P450s; DC: Dendriti[r] ...
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Regulation of Porcine Hepatic Cytochrome P450 by Chicory Root Implication of Boar Taint
... The hepatic cytochrome P450s (CYP450) is a family of enzymes, important for the Phase I metabolism of xenobiotics and endogenous compounds. Many factors are involved in the regulation of CYP450 activity ...
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Dissecting the organ specificity of insecticide resistance candidate genes in Anopheles gambiae : known and novel candidate genes
... and cytochrome P450s (P450s)) and a number of individual enzymes, most notably from the cytochrome P450 family, have been implicated in conferring resistance to one or more insecticide classes ...
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First Report of Biochemical Mechanisms of Insecticide Resistance in the Field Population of Culex pipiens (Diptera: Culicidae) From Sari, Mazandaran, North of Iran
... (GSTs), cytochrome p450s and esterase’s (ESTs) are three main enzyme groups responsible for metabolic resistance to the main classes of in- secticide applied against insects of public health importance (32, ...
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Dissecting the organ specificity of insecticide resistance candidate genes in Anopheles gambiae: known and novel candidate genes
... The cytochrome P450 family has been most strongly linked with insecticide resistance in Anopheles mosquitoes, with several enzymes capable of detoxifying insecticides from more than one class ...thirteen ...
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Energetic costs of detoxification systems in herbivores feeding on chemically defended host plants: a correlational study in the grain aphid, Sitobion avenae
... Herbivorous insects have developed mechanisms to cope with plant barriers, including enzymatic systems to detoxify plant allelochemicals. Detoxification systems may be induced when insects are feeding on plants with ...
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Structure of yeast cytochrome c oxidase in a supercomplex with cytochrome bc1
... Despite its lack of complex I (CI), Saccharomyces cerevisiae has been extensively used as a model system for the study of mitochondrial respiratory chains, given its unique genetic amenability 14 . In the case of CIV, S. ...
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Clinical outcomes and management of mechanism-based inhibition of cytochrome P450 3A4
... of cytochrome P450 (CYP) 3A4 is characterized by NADPH-, time-, and concentration-dependent enzyme inactivation, occurring when some drugs are converted by CYPs to reactive ...
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Pyriproxyfen is metabolized by P450s associated with pyrethroid resistance in An. gambiae.
... Emergence inhibition dose response curves for the insecticide susceptible Kisumu 681. strain (continuous line) and insecticide resistant Tiassalé strain (dotted line)[r] ...
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