cytokine signaling
Transcriptional down-regulation of suppressor of cytokine signaling (SOCS)-3 in chronic obstructive pulmonary disease
... (derived from the Drosophila homologue MAD and the C. elegans homologue SMA [12,13]) or suppressors of cytokine signaling (SOCS) [14]. SOCS molecules are a family of pro- teins that function as negative ...
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Romidepsin suppresses monosodium urate crystal induced cytokine production through upregulation of suppressor of cytokine signaling 1 expression
... of cytokine signaling (in this manuscript SOCS1 and SOCS3); STAT: Signal transducer and activator of transcription; TIRAP: TIR- domain containing adapter protein; TLR: Toll-like ...
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Expression of suppressors of cytokine signaling during liver regeneration
... The cytokines TNF and IL-6 play a critical role early in liver regeneration following partial hepatectomy (PH). Since IL-6 activates signal transducers and activators of transcription (STATs), we examined whether the ...
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Suppressor of cytokine signaling (SOCS) genes are downregulated in breast cancer
... of cytokine signaling (SOCS) family of proteins have been recognized as potent inhibitors of the cytokine-activated Janus kinase/signal transducers and activators of transcription (JAK/STAT) ...
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Following the cytokine signaling pathway to leukemogenesis: a chronology
... Studies over the past 50 years revealing the molecular events that promote normal T lymphocyte cycle competence and progression led to a detailed understanding of how cytokines function to regulate normal hematopoietic ...
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Kaposi's Sarcoma-Associated Herpesvirus Inhibits Expression and Function of Endothelial Cell Major Histocompatibility Complex Class II via Suppressor of Cytokine Signaling 3
... Endothelial cells (EC) can present antigen to either CD8 ⴙ T lymphocytes through constitutively expressed major histocompati- bility complex class I (MHC-I) or CD4 ⴙ T lymphocytes through gamma interferon (IFN-␥)-induced ...
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The regulation of cytokine signaling by retinal determination gene network pathway in cancer
... of cytokine pathways can promote the proliferation, tumorigenesis, angiogenesis, and metastasis of tumor ...Specifically, cytokine is a critical mediator in the regulatory function of RDGN in tumor ...
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Pathways and mechanisms for cytokine signaling of the central nervous system
... Thus, the key question in the field remains unanswered. In response to peripheral inflammation, peripheral cytokines such as IL-1 b are synthesized and may circulate in the blood stream. This is followed by the synthesis ...
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Negative regulation of cytokine signaling and immune responses by SOCS proteins
... There is accumulating evidence that SOCS3 could suppress inflammatory reactions in pathological situations in which IL- 6-related cytokines have important progressive functions. This is because SOCS3 is a relatively ...
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gp130 cytokine signaling in the pituitary gland: a paradigm for cytokine–neuro endocrine pathways
... gp130 cytokines are powerful stimuli for ACTH secre- tion by pituitary corticotrophs in vitro and in vivo in different species (4, 5, 19). IL-6 stimulates the release of ACTH in normal rats, and suboptimal amounts of ...
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Inhibition of miRNA 222 3p Relieves Staphylococcal Enterotoxin B Induced Liver Inflammatory Injury by Upregulating Suppressors of Cytokine Signaling 1
... nodes cells obtained from naive WT mice expressed signifi- cantly higher level of SOCS1 when activated with SEB for 24 h, but also suggested that abundant increase of SOCS1 occurred in lung-infiltrating mononuclear cells ...
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Il-10 Family Members as Novel Responders to Genotoxic Stress
... SASP signaling, including IL-1 and ataxia telangiectasia mutated ...induced cytokine signaling, and open up the possibility of manipulating these factors in the treatment of cancer and age-related ...
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STAT3 Ubiquitylation and Degradation by Mumps Virus Suppress Cytokine and Oncogene Signaling
... Mumps virus V inhibits cytokine and oncogene signaling. STAT3 activation and transcription factor activity have been well studied for cytokine signaling systems similar to IL-6 (27). To test ...
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Gene variants of interleukin-1 (il-1) and their role in development of osteoarthritis
... 2013. Cytokine signaling-1 suppressor is inducible by ta and inhibits the catabolic effects of IL-1 beta in chondrocytes: its implication in the paradoxical joint- protective role of IL-1 ...
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IL-27 mediates HLA class I up-regulation, which can be inhibited by the IL-6 pathway, in HLA-deficient Small Cell Lung Cancer cells
... GP130 signaling, in- duced by IL-6 ligands, may switch-off the responsiveness to IL-27, through the induction of the suppressor of cytokine signaling, SOCS3, in human hepatocellular car- cinoma cells ...
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Latent Gammaherpesvirus 68 Infection Induces Distinct Transcriptional Changes in Different Organs
... System Cytokine Signaling in Immune system Interferon Signaling Immunoregulatory interactions between Cell adhesion molecules (CAMs) Chemokine signaling pathway T Cytotoxic Cell Surface ...
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STAT3 and STAT1 mediate IL 11–dependent and inflammation associated gastric tumorigenesis in gp130 receptor mutant mice
... gp130 cytokine receptor signaling subunit that cannot bind the negative regulator of cytokine signaling SOCS3 and is characterized by hyperactivation of the signaling molecules STAT1 ...
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Review Article Treatment of bronchopulmonary dysplasia by vascular endothelial growth factor: the earlier the better?
... VEGF signaling is absolutely critical for vascular development and embryonic survival, and appears to protect the lung against hyperoxia or cytokine-induced endothelial cell ...VEGF signaling impairs ...
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Spotlight on the NLRP3 inflammasome pathway
... or cytokine receptor activation prime NLRP3 through NF-κB-dependent transcriptional upregulation of NLRP3 and putative other ...TRIF-dependent signaling drives this late transcriptional ...
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Neuropathies of Stuve-Wiedemann Syndrome due to mutations in leukemia inhibitory factor receptor (LIFR) gene
... Even in the cases where LIFR signaling is known to be the root cause of STWS, connections between signaling and symptoms have not been fully elucidated. As many cytokines possess redundant roles, it is ...
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