Cytoplasmic tail
The Cytoplasmic Tail of the Influenza A Virus M2 Protein Plays a Role in Viral Assembly
... M2 cytoplasmic-tail deletion mutant viruses by reverse ...the cytoplasmic tail of the influenza A virus M2 protein, we constructed a series of PolI plasmids that encoded M2 mutants with ...
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Mutation of the YXXL Endocytosis Motif in the Cytoplasmic Tail of Pseudorabies Virus gE
... gE cytoplasmic tail consisting of 167 amino acids as depicted in ...the cytoplasmic tails of cell surface receptors that physically interact with the cellular machinery involved in endocytosis: ...
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Functional analysis of the cytoplasmic tail of Moloney murine leukemia virus envelope protein.
... the cytoplasmic tail that decreased the ability of the envelope protein to mediate cell-cell fusion were also detrimental to retroviral ...the tail amino terminal to the R-peptide cleav- age ...these ...
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Mutational Analysis of the Cytoplasmic Tail of Jaagsiekte Sheep Retrovirus Envelope Protein
... the cytoplasmic tail mutations could affect transformation and viral replication by independent or related mechanisms, or ...mic tail, it is possible that interactions important for transfor- mation ...
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Role of the Cytoplasmic Tail of Pseudorabies Virus Glycoprotein E in Virion Formation
... gE tail does not markedly impair the production of infectious virus, although infected cells were observed to occasionally contain intracytoplasmic aggregations of amorphous material devoid of ...gE ...
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The Cytoplasmic Tail of Infectious Bronchitis Virus E Protein Directs Golgi Targeting
... Several types of viruses derive their lipid envelopes by bud- ding into the membranes of the Golgi complex (14). While there is still much to learn about the mechanisms and advan- tages of this interesting process, it is ...
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Elongation of the Cytoplasmic Tail Interferes with the Fusion Activity of Influenza Virus Hemagglutinin
... plasmic tail, and it is generally assumed that by interacting with the matrix protein, the tail plays an important role in virus ...the cytoplasmic tail of FPV HA interferes with fusion while ...
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Alphavirus assembly and entry: role of the cytoplasmic tail of the E1 spike subunit.
... 7560-7564 0022-538X/92/127560-05$02.00/0 Copyright © 1992, American Society for Microbiology Alphavirus Assembly and Entry: Role of the Cytoplasmic Tail of the El Spike Subunit BERND UWE[r] ...
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NPXY Motifs in the β1 Integrin Cytoplasmic Tail Are Required for Functional Reovirus Entry
... integrin cytoplasmic tail contains two NPXY motifs, which function in recruitment of adaptor proteins and clathrin for endocytosis and serve as sorting signals for internalized ...integrin ...
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Novel Approach to the Development of Effective H5N1 Influenza A Virus Vaccines: Use of M2 Cytoplasmic Tail Mutants
... M2 cytoplasmic tail caused a growth defect in A/WSN/33 (H1N1) influenza A virus in vitro ...M2 tail mutants as live attenuated vaccines against H5N1 ...M2 cytoplasmic tail deletion ...
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Alterations to influenza virus hemagglutinin cytoplasmic tail modulate virus infectivity.
... Because 5 of the 10 cytoplasmic domain residues from nearly all influenza A virus subtypes are conserved and deletion of the cytoplasmic tail of HA does not prevent its intracellular tra[r] ...
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The Cytoplasmic Tail Domain of Influenza B Virus Hemagglutinin Is Important for Its Incorporation into Virions but Is Not Essential for Virus Replication in Cell Culture in the Presence of Compensatory Mutations
... BHA cytoplasmic tail mutant virus with labeled ...BHA cytoplasmic tail does not affect its fusion activity ...BHA cytoplasmic tail is required for membrane fusion in the context ...
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The frantic play of the concealed HIV envelope cytoplasmic tail
... Abbreviations Ab: Antibody; AP: Adaptor protein; CA: Capsid; CaM: Calmodulin; CT: Cytoplasmic tail; Env: Envelope; ER: Endoplasmic reticulum; gp: Glycoprotein; HA: Hemagglutinin; HCV: He[r] ...
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The Glycoprotein Cytoplasmic Tail of Uukuniemi Virus (Bunyaviridae) Interacts with Ribonucleoproteins and Is Critical for Genome Packaging
... seven segments surrounding one in the middle (29). All seg- ments contain sequences important for packaging in both the NCR and the open reading frame (ORF) (8, 9, 26, 45). These ORF sequences might serve as linking ...
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Retrovirus Glycoprotein Functionality Requires Proper Alignment of the Ectodomain and the Membrane-Proximal Cytoplasmic Tail
... Nonnative viral glycoproteins, including Friend murine leukemia virus envelope (F-MLV Env) are actively recruited to HIV-1 assembly sites by an unknown mechanism. Because interactions with the lipid microenvironment at ...
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Role of the Cytoplasmic Tail of Equine Infectious Anemia Virus Transmembrane Glycoprotein in Acute Disease Induction
... called cytoplasmic tail (CT) (Figure ...C-terminal tail of the HIV-1 gp41 contains a neutralizing ...C-terminal tail of gp41 containing that epitope was looped back through the viral membrane ...
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The Cytoplasmic Tail Domain of Epstein Barr Virus gH Regulates Membrane Fusion Activity through Altering gH Binding to gp42 and Epithelial Cell Attachment
... gH cytoplasmic tail deletion ...gH tail and the varicella-zoster virus (VZV) gH tail found that truncation of the gH cytoplasmic tail domain (CTD) alters fusion activity (17, 21, ...
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Mutations in the cytoplasmic tail of influenza A virus neuraminidase affect incorporation into virions.
... Transfectant virus was obtained with all cytoplasmic tail mutants generated by site-directed mutagenesis of the influenza A virus tail, except for the mutant resulting from substitution [r] ...
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The Neuroinvasiveness of a Murine Retrovirus Is Influenced by a Dileucine-Containing Sequence in the Cytoplasmic Tail of Glycosylated Gag
... To determine whether these differences in cell surface ex- pression of glycosylated Gag were also seen in vivo, spleen cells were harvested from mice 14 days after neonatal inoculation of KP and KP41 and similarly ...
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Regulation of Adenovirus Membrane Penetration by the Cytoplasmic Tail of Integrin β5
... 3) cytoplasmic tail (CT) supported normal levels of Ad endocytosis but had reduced Ad-mediated gene delivery and membrane permeabilization relative to cells expressing a wild-type integrin  ...escape ...
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