cytosine arabinoside
Can Cytosine Arabinoside With Prednisolone Treatment for Canine Meningoencephalitis of Unknown Origin Increase Survival Time Compared to Prednisolone Treatment Alone?
... You are presented with a 4-year-old male neutered Boston Terrier with a five day history of seizures, progressive mentation changes and compulsive circling. The patient has had no previous ailments or been on any ...
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Docosahexaenoic Acid Reduces Cyto- Genotoxicity of Cytosine Arabinoside in Normal Mouse Bone Marrow
... Aims: This paper evaluates the use of percentage of micronucleus (MN), polychromatic erythrocytes (PCEs), chromosomal aberration (CA) and mitotic index (MI) frequencies in mice bone marrow smears as a method for ...
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<p>Aprepitant Sensitizes Acute Myeloid Leukemia Cells to the Cytotoxic Effects of Cytosine Arabinoside in vitro and in vivo</p>
... of cytosine arabinoside (Ara-C) and anthracyclines with disappointing clinical outcomes and severe adverse effects, such as symptomatic bradycardia, ...
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CYTOGENETIC EFFECTS OF MAGNETIC AND RADIOFREQUENCY FIEL DS OF NMRI SYSTEMS ON THE FREQUENCY OF CHROMOSOMAL ABERRATIONS INHUMAN LYMPHOCYTES IN THE PRESENCE OR ABSENCE OF CYTOSINE ARABINOSIDE
... F ollowing exposure of GO and G2 cells to NMRI in the presence of ara-C, the' yield of chromosomal aberra tions did not differ with ara-C treated cells (Table I and II). It is shown that ara-C is able to increase the ...
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Low frequency of pre-treatment and post-treatment haematological abnormalities in dogs with non-infectious meningoencephalitis treated with cytosine arabinoside and prednisolone
... ► Additional material is published online only. To view please visit the journal online (http:// dx. doi. org/ 10. 1136/ vetreco- 2018- 000315). To cite: Keegan S, Rose JH, Khan Z, et al. Low frequency of pre-treatment ...
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Effect of uracil arabinoside on metabolism and cytotoxicity of cytosine arabinoside in L5178Y murine leukemia
... It is postulated that the systemic metabolism of high-dose ara-C to sustained high levels of ara-U in patients with acute leukemia may enhance the activity of subsequent doses of ara-C, [r] ...
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Mechanism of synergistic cell killing when methotrexate precedes cytosine arabinoside: study of L1210 and human leukemic cells
... This Therefore, drugs which would lower dCTP pools would enhancement of Ara-C entry into cells was only ob- be expected to produce greater quantities of Ara-C served when the dose of MTX[r] ...
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Preparation and in vitro antitumor effects of cytosine arabinoside-loaded genipin-poly-L-glutamic acid-modified bacterial magnetosomes
... Moreover, the ABMs-P prepared in this study showed strong cytotoxicity to HL-60 cells, similar to Ara-C, which could make this an appropriate controlled long-term drug release system [r] ...
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Cytosine arabinoside transport and metabolism in acute leukemias and T cell lymphoblastic lymphoma
... Blast cells from various leukemias were assayed for maximal density of nucleoside transport sites step 1 and maximal activities of deoxycytidine kinase step 2, pyrimidine nucleoside mono[r] ...
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Effect of cytosine arabinoside on viral-specific protein synthesis in cells infected with herpes simplex virus.
... From these results, we conclude that ara-C has little effect upon early HSV-1 protein synthesis but causes a rapid drop of amino acid incorporation into late HSV-1 proteins which begins [r] ...
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Membrane transport influences the rate of accumulation of cytosine arabinoside in human leukemia cells
... At low extracellular ara-C concentrations, an increase in transport capacity results in an increase in the concentration of intracellular ara-C nucleoside, which results in an increase i[r] ...
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Cytosine Arabinoside Influx and Nucleoside Transport Sites in Acute Leukemia
... The number of nucleoside transport sites was estimated for each cell type by measuring the equilibrium binding of [3H]nitrobenzylthioinosine NBMPR, which inhibits nucleoside fluxes by bi[r] ...
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Genetic characterization of the vaccinia virus DNA polymerase: cytosine arabinoside resistance requires a variable lesion conferring phosphonoacetate resistance in conjunction with an invariant mutation localized to the 3'-5' exonuclease domain.
... Mapping of the lesions conferring araCr by marker rescue of PAA' congenic isolates with subclones of five araCr DNA polymerase alleles DNA fragmente Titration of yield PFU/ml6 Recipient [r] ...
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Redirection of CD4+ and CD8+ T lymphocytes via an anti-CD3 × anti-CD19 bi-specific antibody combined with cytosine arabinoside and the efficient lysis of patient-derived B-ALL cells
... Methods: This study aimed to detect the B7 family members B7.1 (CD80) and B7.2 (CD86) that were expressed in B-ALL patient-derived cells pre-treated by Ara-C (0.25 μ M) and to determine [r] ...
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Compound kushen injection suppresses human acute myeloid leukaemia by regulating the Prdxs/ROS/Trx1 signalling pathway
... The antioxidant CKI could markedly inhibit THP-1, U937, HL60 and Molm-13 cell proliferation (Fig. 2a). Addition- ally, the cell proliferation of human AML cells, which were separated from AML patients, was significantly ...
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Fowlpox Virus Encodes a Novel DNA Repair Enzyme, CPD-Photolyase, That Restores Infectivity of UV Light-Damaged Virus
... after the onset of viral DNA replication (Fig. 3A). Similar results were obtained using primers specific for an A-type inclusion body protein gene transcript predicted to be pro- duced late based on the conservation of ...
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Remission of HIV-related naïve and high-risk Burkitt’s lymphoma treated by autologous stem cell transplantation plus cART
... Ara-C: Cytosine arabinoside; ART: Antiretroviral therapy; ASCT: Autologous stem cell transfusion; BL: Burkitt ’ s lymphoma; cART: Combined antiretroviral therapy; FDG: Fludeoxyglucose; G-CSF: ...
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Kinetics of murine type C virus-specific DNA synthesis newly infected cells.
... This report summarizes the results of experiments designed to determine: i the critical time for provirus formation using the inhibitor of DNA synthesis cytosine arabinoside; ii the kine[r] ...
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Synthesis of polynucleotide 5'-triphosphatase in vaccinia virus-infected HeLa cells.
... Effect of cytosine arabinoside on the synthesis of polynucleotide 5'-triphosphatase and nucleic acid-dependent nucleoside triphosphate phosphohydrolase activity in infected cells.. A dis[r] ...
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A clinical-molecular update on azanucleoside-based therapy for the treatment of hematologic cancers
... Azacitidine was also evaluated as an addition to standard intensive chemotherapy with the cytotoxic agents daunorubicin and cytosine arabinoside (ARA-C) for the treatment of elderly AML [r] ...
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