Cytosolic phospholipase A2
Identification of the mechanism for the inhibition of Na+,K(+) adenosine triphosphatase by hyperglycemia involving activation of protein kinase C and cytosolic phospholipase A2
... Inhibition of Na+,K(+)-ATPase activity by hyperglycemia could be an important etiological factor of chronic complications in diabetic patients. The biochemical mechanism underlying hyperglycemia's inhibitory effects has ...
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Impacts of Cytosolic Phospholipase A2, 15 Prostaglandin Dehydrogenase, and Cyclooxygenase 2 Expressions on Tumor Progression in Colorectal Cancer
... Purpose: In addition to cyclooxygenase-2 COX-2 which is related to prostaglandin E2 synthesis, other enzymes such as cytosolic phospholipase A2 cPLA2, microsomal prostaglandin E2 synthas[r] ...
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Interferon gamma induces the synthesis and activation of cytosolic phospholipase A2
... of phospholipase A2 (PLA2) in BALB/c 3T3 fibroblasts and a human neuroblastoma cell ...of cytosolic phospholipase A2 (cPLA2) in a human bronchial epithelial cell line (BEAS ...
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Activatable Fluorophores for the Molecular Imaging of Cytosolic Phospholipase A2 in Breast Cancer
... cancer. Cytosolic Phospholipase A2 (cPLA2) activity is enhanced in triple negative breast cancer and is associated with resistance to therapy in luminal-like ...
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Cytosolic Phospholipase A2 Gamma Is Involved in Hepatitis C Virus Replication and Assembly
... the cytosolic endoplasmic reticulum (ER) ...the cytosolic phospholipase A2 gamma (PLA2G4C), which contributes to MW formation, HCV replication, and ...
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Inhibition of cytosolic phospholipase A2 prevents prion peptide-induced neuronal damage and co-localisation with Beta III Tubulin
... As the translocation of p-cPLA 2 within neuronal neur- ites in the presence of HuPrP106-126 had not been pre- viously reported the question whether HuPrP106-126 treatment leads to a pote[r] ...
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Effect of Kaempferol on Cyclooxygenase 2 (Cox2) and Cytosolic Phospholipase A2 (cPLA2) Protein Expression in BALB/c Mice
... Kaempferol, a phytochemical found in many edible plants, is known to alleviate diseases such as cancer, allergy, and inflammation. The objective of this study was to investi[r] ...
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Cytosolic phospholipase A2 plays a crucial role in ROS/NO signaling during microglial activation through the lipoxygenase pathway
... LPS- and IFN γ -induced iNOS expression and NO production are significantly decreased in microglia deficient in cPLA 2 In this study, primary microglial cells isolated from WT and cPLA 2[r] ...
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Inherited human group IVA cytosolic phospholipase A2 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation
... Figure 4. Contribution of cPLA 2a to eicosanoid synthesis in leukocytes. A ) Eicosanoid levels in whole blood from healthy volunteers or from a patient lacking cPLA 2a treated with LPS ([r] ...
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Increase of cytosolic phospholipase A2 as hydrolytic enzyme of phospholipids and autism cognitive, social and sensory dysfunction severity
... Methods: Phospholipids (PE, PS, PC) and cPLA2 as biochemical parameters were determined in the plasma of 48 Saudi autistic male patients, categorized as mild-moderate and severe as indic[r] ...
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Interleukin 1 alpha causes rapid activation of cytosolic phospholipase A2 by phosphorylation in rat mesangial cells
... We have shown previously that interleukin 1 (IL-1) stimulates eicosanoid production in glomerular mesangial cells (MC) by de novo synthesis of a 14-kD, group II phospholipase A2 (PLA2). IL-1-stimulated ...
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The activity of cytosolic phospholipase A2 is required for the lysis of adenovirus-infected cells by tumor necrosis factor.
... This conclusion is based largely on the activity of an antisense oligonucleotide corresponding to cPLA2, which completely inhibited the release of both [3H]arachidonic acid and 51Cr, ind[r] ...
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Cytosolic phospholipase A2 in hypoxic pulmonary vasoconstriction
... The authors thank Clary B. Clish for initial MS-MS analysis, Gudrun Mirick for technical assistance, Yuchiao Chang for statistical advice, and Edward A. Dennis for advice on the phospholipase activity assay. This ...
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Cytosolic phospholipase A2 regulates Golgi structure and modulates intracellular trafficking of membrane proteins
... (35). Phospholipase D is present in Golgi membranes (36), is activated by ADP-ribosyla- tion factor (37), and is responsible for catalyzing the transphosphatidylation reaction of phosphatidic acid and ...
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Isolation of a human myocardial cytosolic phospholipase A2 isoform Fast atom bombardment mass spectroscopic and reverse phase high pressure liquid chromatography identification of choline and ethanolamine glycerophospholipid substrates
... minor cytosolic calcium-independent phospholipase A2 isoform that hydrolyzes plasmenylcholine and phosphatidylcholine substrates at similar rates and possesses a pH optimum of ...major ...
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Cytosolic phospholipase A2 regulation in the hibernating thirteen-lined ground squirrel
... Arachidonic acid is a key molecule in cells and the precursor to several metabolic pathways including the production of lipid messengers such as the eicosanoids (e.g. prostaglandins, aromatic hormones, leukotrienes, ...
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Regulatory role of cytosolic phospholipase A2 alpha in the induction of CD40 in microglia
... f FACS analysis of CD40 protein expression in the unstimulated or stimulated BV-2 cells with 50 ng/ml LPS for 24 h in the absence or presence of 2 μ m pyrrophenone or 5 μ m DPI (added to[r] ...
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Bacterial lipopolysaccharide primes human neutrophils for enhanced release of arachidonic acid and causes phosphorylation of an 85 kD cytosolic phospholipase A2
... Production of leukotriene B4 (LTB4) by human neutrophils (PMN) in response to different stimuli is increased after pretreatment with lipopolysaccharides (LPS). We have analyzed the steps in arachidonic acid (AA) ...
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Inhibition of cyclin-dependent kinase 5 affects early neuroinflammatory signalling in murine model of amyloid beta toxicity
... cPLA2: Cytosolic phospholipase A2; EDTA: Ethylenediaminetetraacetic acid; ERK: Extracellular signal-regulated kinase; GAPDH: Glyceraldehyde 3-phosphate dehydrogenase; GFAP: Glial fibrillary acidic ...
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The VP1 Unique Region of Parvovirus B19 and Its Constituent Phospholipase A2-Like Activity
... their phospholipase A2 activity ...pholipase A2 activity. The reason that parvovirus B19 has phospholipase A2 activity as part of the virion remains unex- ...the phospholipase ...
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