Cytotoxic action
The effect of oxygen tension on the cytotoxic action of tumour necrosis factor-alpha
... The cell cycle was followed by BrdUrd pulse labelling during the priming period. It was found that priming cells for 24 h in 0.2% oxygen causes delays in all phases of the cell cycle but the most significant delay was ...
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Cytotoxic action of silver nanoparticles synthesized from Phyllanthus fraternus on hepatic and breast cancer cell lines: A green approach
... vitro cytotoxic result showed an excellent half maximal inhibitory concentration value of ...high cytotoxic action against HepG-2 and MCF-7 cell lines which suggested the potential therapeutic use of ...
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The sensitivity of cells with the various level of NAD(P)H:quinone oxidoreductase 1 to cytotoxic action of quinonimines and α-тоcopherol synthetic derivatives
... the cytotoxic effect of DCPIP was inversely proportional to the basal level of DT-diaphorase activity and accompanied by its activation with subsequent inhibition at non-toxic and toxic concentrations, ...the ...
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Induction of sensitivity to the cytotoxic action of tumor necrosis factor alpha by adenovirus E1A is independent of transformation and transcriptional activation.
... To analyze the role of CR1 and CR2 in the induction of TNFot sensitivity in greater detail, multiple G418-coselected NIH 3T3 cell lines expressing selected partial functional-defect were[r] ...
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Resveratrol exhibits a strong cytotoxic activity in cultured cells and has an antiviral action against polyomavirus: potential clinical use
... In last decade we investigated the role of both natural and synthetic substances on Py DNA replication and RNA transcription [8-10]. Also, the cellular and metabolic response after exposure to these substances was ...
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Stengl, Andreas (2019): Site-specific bioorthogonal modification of antibodies and T cell receptor ligands for use in cancer therapy and research. Dissertation, LMU München: Fakultät für Biologie
... the cytotoxic payload an ADC has a third critical component - the linker (Figure ...their cytotoxic action (Figure ...used cytotoxic agents are hydrophobic and destabilize the antibody when ...
240
Obatoclax impairs lysosomal function to block autophagy in cisplatin-sensitive and -resistant esophageal cancer cells
... Many studies have shown that obatoclax induces apoptosis by suppressing anti-apoptotic family members of Bcl-2 [14–17]. However, the cytotoxicity of obatoclax has also been observed in Bax- and Bak- deficient cells, ...
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AN EXPERIMENTAL APPRAISAL OF THE SAFETY AND EFFICACY OF AN AYURVEDIC HERBOMINERAL COMPOUND MEHAKULANTHAKA RASA
... causes hyperglycaemia mainly by its direct cytotoxic action on the pancreatic beta cells. [13] STZ is a preferred agent to induce experimental diabetes since it has some advantages over Alloxan such as, ...
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Linoleic acid suppresses colorectal cancer cell growth by inducing oxidant stress and mitochondrial dysfunction
... tumoricidal action, but their exact mechanism(s) of action is not ...anti-cancer action of LA is due to enhanced ROS generation and decreased cell anti-oxidant capacity that resulted in mitochondrial ...
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“Oxaliplatin: A Review of Its Use in Advanced Colorectal Carcinoma” by Nusrat Bano, Rahila Najam, Pakistan. Digital copy link
... The cytotoxic actions of all the platinum compounds is due to DNA damage 8 ...The cytotoxic action of oxaliplatin is by formation of DNA adducts that prevents the replication and transcription 9-11 ...
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Multiple roles of dihomo-γ-linolenic acid against proliferation diseases
... implies that an interaction exists among fatty acids, lipid peroxidation process, apoptosis and genes/oncogenes that regulate apoptotic process [6-10]. Researches pre- viously have showed that some polyunsaturated fatty ...
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Green Synthesis of Silver nanoparticles using Scindapsus officinalis (Gajpipli): In-vitro cytotoxic activity against HepG-2 & MCF-7 cancer cell lines Manish Pathak a,Vikas Kumar Prateek Pathak bRahul Majeec ,Pramod W. Ramteke d Amita Verma* a
... Previous literature studies has reported about silver nanoparticles as anti-cancer agent & their role as an anti-cancer agent could explore newer treatment therapy in the area of pharmaceuticals with help treatment ...
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Potential anti tumour compounds from marine sources
... To explore the possibility that the cytotoxicity type was related to the mechanism of cytotoxic action, several registered clinical drugs, possessing a wide range of known in vivo modes [r] ...
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PHYTOCHEMICAL INVESTIGATION AND BIOLOGICAL ACTIVITES OF THYMUS DECUSSATUS BENTH GROWING IN EGYPT
... of cytotoxic activity revealed the significant cytotoxic activity against Ehrlich ascites carcinoma cells (EAC), as well as two human cancer cell lines (U251) brain- tumor and (Hepg2) liver carcinoma cell ...
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“Phytochemical, Antibacterial and Cytotoxic Screening of Salicia fruticosa Heyne Ex Lawson., Aerial Parts - in vitro Model” by Dhanalakshmi M, Prabhavathi.K, Pradeepti.K.G, Manjula Devi K, Senthil Rajan D, India.
... regarding cytotoxic and antibacterial activity of aerial part of various ...vitro cytotoxic activity of various extracts were ...vitro cytotoxic activity, the ethanolic extract showed potent ...
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Biological Activity of Levan Produced from Rhizospheric Soil Bacterium Brachybacterium phenoliresistens KX139300 Mohammad M.F. Al-Halbosiy| Zaid A. Thabit| Safaa Al-Deen A. S.Al-Qaysi| Tarek A.A. Moussa
... Levan is an exopolysaccharide produced by various microorganisms and has a variety of applications. In this research, the aim was to demonstrate the biological activity of levan which produced from B. phenoliresistens ...
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Cytotoxic activity screening of ethyl acetate fungal extracts derived from the marine sponge Neopetrosia chaliniformis AR-01
... study, cytotoxic screening was performed using a WiDr colon cancer cell line and the cytotoxic effect compared with normal VERO ...for cytotoxic testing (Rohmah et ...
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Article: Cytotoxic potential of camel whey and milk on cervix cancer (HeLa) cell line
... activities (Harmsen and De Haard, 2007). Traditionally, camel milk has cured and treated numerous cases of cancer. The anticancer potential of camel milk was referred to its cytotoxic effect, anti-apoptotic effect ...
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The study of anticancer and antifungal activities of Pistacia integerrima extract In vitro
... of 200 µg/ml showed ~100 and 97.4% inhibition against Michigan Cancer Foundation-7 cell line, respectively. The crude methanol extract also showed good antitumour (IC 50 125 ppm) activity, but weak antifungal activity. ...
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Journal of Applied Pharmaceutical Science
... metabolizes AQ4N under anoxic conditions to AQ4M and AQ4. When compared with the control samples, where PBS was used instead of the CYP2S1, there was no conversion of AQ4N to AQ4M or AQ4-there was only a single peak ...
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