Cytotoxic Agents
A REVIEW ON QUINAZOLES AS CYTOTOXIC AGENTS
... We worked out for the review on Quinazoles as Angiogenesis Inhibitors and Cytotoxic agents; it would be helpful to those who are working on cancer research. Cancer is one of the world’s most pressing health ...
7
Biological evaluation of 8 alkyl xanthines as potential cytotoxic agents
... fectants, the radiosensitization by methyl xanthines operates more effectively in p53 mutant than in p53 wild type cells [6]. Furthermore, it was shown that caffeine (2.5 mM) treatment reversed the adriamycin inducing ...
6
Design, Synthesis, Characterization and Computational Evaluation of Novel Isobutychalcones as Cytotoxic Agents: Part-A
... anticancer agents in the last 15 years ...[14]. Cytotoxic and anticancer activities are mediated by modulating important molecular pathways or targets including, P-glycoprotein-mediated multidrug ...
20
Nicotinamide-based diamides derivatives as potential cytotoxic agents: synthesis and biological evaluation
... moderate cytotoxic effects on lung cancer cell lines (NCI-H460, A549, and NCI-H1975), especially, compound 4d exhibited the highly potential inhibitory activi- ties against NCI-H460 cell line with the IC 50 values ...
9
SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NEW CHALCONES AS POTENTIAL CYTOTOXIC AGENTS
... Chalcones, a group of compounds with two aromatic rings connected by a keto-vinyl chain, constitute an important class of naturally occurring flavonoids exhibiting a wide spectrum of biological activities. The presence ...
10
NOVEL QUINAZOLINE SCAFFOLDS AS EGFR INHIBITORS: AN INSIGHT TO DISCOVERY OF CYTOTOXIC AGENTS
... No of studies has explored their SAR, as well as conformation and orientation requirements for kinase binding site through modeling studies. SAR studied also showed that smaller substituents did not have any significant ...
9
Synthesis of nitric oxide donating acridone derivatives as cytotoxic agents in cancer
... good cytotoxic effect as well as significant rate of nitrite ...the cytotoxic property of ...when cytotoxic data of these molecules compared with nitrite ...the cytotoxic effect of the ...
8
SYNTHESIS OF LORATADINE AND SOME OF ITS AMIDE DERIVATIVES AS CYTOTOXIC AGENTS
... least cytotoxic activity, whereas ethylenediamine derivative (4) and propylenediamine derivative (5) showed more cytotoxic activity than their precursor drug loratadine (2) with the propylenediamine ...
6
Synthesis and Biological Evaluation of 2-Phenyl Benzothiazole Derivatives as Cytotoxic Agents
... 36.6 µM). Compound 2 was determined as the least active compound, while conversion of amide to thioamide functionality enhanced the cytotoxic activity. The acetylation of amino group markedly increased the ...
6
The In Silico Screening of Pyrazolo[3,4 E][1,4]Thiazepine Derivatives as Potent Cytotoxic Agents
... 3,4-di hydro-5-oxo-1,4-benzothiazepine alkyl derivatives were described as HIV-1 enzyme integrase [6], reverse transcriptase inhibitors [7], and antitumor agents [8]. The core unit hetero ring systems are potent ...
7
In Vitro Evaluation of Monohalogenated Semicarbazones and Thiosemicarbazones as Potential Cytotoxic Agents Induction of Apoptosis and Genotoxicity
... A series of halogenated Semicarbazones (SCs) and Thiosemicarbazones (TSCs) (11-30) were synthesized from mono fluorinated-, bromine- and chlorinated acetophenones (1-10). Structures were confirmed by Nuclear Magnetic ...
5
Current Cytotoxic Agents and Novel Therapy for Metastasis Nasopharyngeal Cancer
... Synergistic cytotoxic effects between gemcitabine and cisplatin (GC) have been observed both in vivo and in vitro. This combination is ease of administration and can be given as an ambulatory outpatient schedule. ...
17
THE BIOLOGICAL ACTIVITY OF CONOCARPUS ERECTUS EXTRACTS AND THEIR APPLICATIONS AS CYTOTOXIC AGENTS
... a cytotoxic effect against ECA and L cells were in range 2µg/ml, additionally it showed 100% hemolysis of bovine erythrocyte at a concentration of 100 µg/ml ...
14
Ru(II) COMPLEXES AS CYTOTOXIC AGENTS: SYNTHESIS AND STRUCTURAL CHARACTERIZATION
... In summary, we described the synthesis of novel ruthenium(II) Complexes bearing dmhc and dmih derivatives. These ruthenium compounds possess excellent in vitro cytotoxic activities.. With the increasing ...
8
Synthesis and Biological Evaluation of Certain New Benzimidazole Derivatives as Cytotoxic Agents New Cytotoxic Benzimidazoles
... Based on incorporation of benzimidazole scaffold at N 1 position of the imidazole ring, scheme 1 utilizes the synthesis of different azo coupling derivatives, starting with ...
9
NEWER APPLICATIONS OF BENZOTHIAZEPINES AS POTENTIAL CYTOTOXIC AGENTS
... possessed cytotoxic activity as evidenced by the IC50 values and is much higher than that of the chalcones indicating the positive contribution of benzothiazepine nucleus in enhancing the cytotoxic ...
5
SYNTHESIS AND SCREENING OF QUINAZOLINE ANALOGUES AS CYTOTOXIC AGENTS
... was observed from the result of VERO cell line. Furthermore, it concluded that compound with unsubstituted piperazine and attachment of electron withdrawing group has been recognized as potent anticancer agent. ...
7
Synthesis of Novel Chromenes as Cytotoxic Agents
... vitro cytotoxic activity when compared to other tested compounds and colchicine as a reference ...promising cytotoxic activity while in case of the tricyclic compounds the activity is reduced nearly by ...
9
Proton pump inhibitors enhance the effects of cytotoxic agents in chemoresistant epithelial ovarian carcinoma
... We then assessed whether pretreatment with omeprazole could reverse the sensitivity to chemotherapy in chemoresistant cell lines (taxane-resistant including HeyA8-MDR and SKOV3-TR; clear cell carcinoma cell lines ...
11
Aptamer-based therapeutic approaches to target cancer wtem cells
... Aptamers are 15-20 times smaller than antibodies and possess a range of advantages over conventional antibodies. Hence they have now emerged as a class of ideal drug delivery agents. Studies have shown that ...
14