Cytotoxicity and cellular uptake studies
Does cytotoxicity of metallointercalators correlate with cellular uptake or DNA affinity?
... platinum uptake and cellular distribution studies, the MTT assay was used to determine the IC 50 values for the metallointercalators and cisplatin with the A549 cancer cell ...
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The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles
... the same particles are retained in the cytoplasma when they are functionalized with amine or carboxyl groups. 87 Studies on isolated DNA revealed thermal stabilization by cationic but not by anionic poly( l ...
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Cytotoxicity and cellular uptake of tri-block copolymer nanoparticles with different size and surface characteristics
... the uptake of smaller PNP 45 particles than that of the larger PNP 90 ...PNP uptake remain available after blocking one receptor ...vitro cellular systems have different physiologies and have dif- ...
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Functionalization of osmium arene anticancer complexes with (poly)arginine : effect on cellular uptake, internalization, and cytotoxicity
... the cytotoxicity of the Arg 5 and Arg 8 conjugates. These studies demonstrate the potential for use of cell- and nucleus-penetrating peptides in targeting organometallic arene anticancer ...
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Functionalization of osmium arene anticancer complexes with (poly)arginine : effect on cellular uptake, internalization, and cytotoxicity
... the cytotoxicity of the Arg 5 and Arg 8 conjugates. These studies demonstrate the potential for use of cell- and nucleus-penetrating peptides in targeting organometallic arene anticancer ...
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Exploring the cytotoxicity, uptake, cellular response, and proteomics of mono- and dinuclear DNA light-switch complexes
... Introduction The spectacular success of cisplatin as an anticancer therapeutic has led to huge growth in research into the interaction of metal complexes with biomolecules. Initial work focussed on Pt II -based analogues ...
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Effects of N-terminal and C-terminal modification on cytotoxicity and cellular uptake of amphiphilic cell penetrating peptides
... intracellular uptake and improved bio-distribution as well as pharmacokinetic ...The cytotoxicity of modified peptides which were physically linked to MTX, considerably higher than both physically linked ...
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Size-dependent cytotoxicity of silver nanoparticles in human lung cells: the role of cellular uptake, agglomeration and Ag release
... Other studies have also reported higher toxicity for smaller compared to larger sized ...35% cytotoxicity following exposure of fish gill cells to doses of 25 μg/mL; thus, a very similar extent of ...
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<p>MWCNT interactions with protein: surface-induced changes in protein adsorption and the impact of protein corona on cellular uptake and cytotoxicity</p>
... two cytotoxicity assays are mainly due to the nature of each ...Previous studies suggested that MWCNTs- COOH attenuate the cytotoxicity by forming holes in the cell ...
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Cytotoxicity Studies on Naproxen and Piroxicam Nanoformulations
... to cellular uptake, these proteins adsorb rapidly onto the surface of NPs, leading to the formation of a so-called “corona”, which may obscure specific recognition of bioligands on the NP surface and hamper ...
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Cytotoxicity of CdTe quantum dots in human umbilical vein endothelial cells: the involvement of cellular uptake and induction of pro-apoptotic endoplasmic reticulum stress
... The eIF2 α phosphorylation inhibitor SAL that can reduce CHOP expression 55 also effectively protects cells against ER stress-mediated apoptosis (Figure 8C). These findings demonstrate the direct participation of ER in ...
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Effect of Surface Functionalization on the Cellular Uptake and Toxicity of Nanozeolite A
... of cytotoxicity studies, to provide that each sample will be chemically identical with these used in internalization studies, Na + ions were exchanged with non-radioactive Ba 2+ ...
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Cellular uptake and imaging studies of glycosylated silica nanoprobe (GSN) in human colon adenocarcinoma (HT 29 cell line)
... the cellular uptake of GSN was about ...average cellular uptake of ...without cytotoxicity, and that using MRI for quantitative estimation of delivery and uptake of targeted ...
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Carbohydrate functionalization of silver nanoparticles modulates cytotoxicity and cellular uptake
... Conclusions Functionalisation of silver nanoparticles with mono- saccharides modulates their cellular uptake and tox- icity. Galactose and mannose-coated nanoparticles were considerably less toxic to both ...
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<p>Size- and cell type-dependent cellular uptake, cytotoxicity and in vivo distribution of gold nanoparticles</p>
... The uptake of 50-nm AuNPs in liver, spleen and kidney was higher than that of 5 nm and 20 nm ones, while the uptake of 5-nm AuNPs in the lung was higher than that of 20 nm and 50 nm ...
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Selection of potential iron oxide nanoparticles for breast cancer treatment based on in vitro cytotoxicity and cellular uptake
... We finally performed a detailed analysis of the toxic effects of SPIONs by flow cytometry (Figures 4, 5 and S8–S10). Remarkably, we did not find a direct correlation between SPION load and toxicity in general. In spite ...
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Shock wave-induced ATP release from osteosarcoma U2OS cells promotes cellular uptake and cytotoxicity of methotrexate
... the cytotoxicity of doxorubicin and methotrexate in osteosarcoma cell lines [8], suggesting that shock waves may sensitize osteosarcoma cells to conventional chemo- ...
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Uptake and cytotoxicity of citrate coated gold nanospheres : comparative studies on human endothelial and epithelial cells
... the uptake behavior in endothelial or epithelial ...different uptake behaviors for citrate-stabilized gold nanoparticles, which might be related to different interactions occurring at the ...
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Uptake and cytotoxicity of citrate-coated gold nanospheres: Comparative studies on human endothelial and epithelial cells
... the uptake behavior in endothelial or epithelial ...different uptake behaviors for citrate-stabilized gold nanoparticles, which might be related to different interactions occurring at the ...
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SYNTHESIS, SELF-ASSEMBLY AND CELLULAR UPTAKE STUDIES OF BIOACTIVE MOLECULES AND DEVELOPMENT OF NEW METHODOLOGIES
... Ph.D Thesis of Manoj Kumar Gupta, Indian Institute of Chemical Tecnology, Hyderabad, Andhra Pradesh, India.. 17.[r] ...
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