de novo lipogenesis
Epistructured catechins, EGCG and EC facilitate apoptosis induction through targeting de novo lipogenesis pathway in HepG2 cells
... Nowadays, metabolic reprogramming is recognized as one of the special features of cancer cells. This reprogram- ming promotes sustained cell over-proliferation with sup- pression of cell apoptosis. In general, normal ...
13
<p>Biguanides Induce Acute de novo Lipogenesis in Human Primary Sebocytes</p>
... stimulate de novo lipogenesis (DNL) in primary sebocytes to signi fi cantly increase sebum ...Methods: De novo lipogenesis was measured in human primary sebocytes using [14C]- ...
11
Hepatic steatosis risk is partly driven by increased de novo lipogenesis following carbohydrate consumption
... Hypertriglyceridemia is a substantial co-morbidity associ- ated with non-alcoholic fatty liver disease (NAFLD), cardio- vascular disease (CVD), type 2 diabetes mellitus (T2DM), hypertension and cancer [1–4]. ...
15
mTOR complex-2 stimulates acetyl-CoA and de novo lipogenesis through ATP citrate lyase in HER2/PIK3CA-hyperactive breast cancer
... production, de novo lipogenesis and mitochondrial physiology, all of which were inhibited by an mTORC1/mTORC2 kinase inhibitor (mTOR-KI) or cellular depletion of mTORC2 or ...in lipogenesis ...
17
The Role of Dietary Sugars and De novo Lipogenesis in Non-Alcoholic Fatty Liver Disease
... stimulate de novo lipogenesis (DNL), stable isotope tracer studies in humans demonstrate quantitatively that the lipogenic effect of fructose is not mediated exclusively by its provision of excess ...
25
Contribution of adipose tissue and de novo lipogenesis to nonalcoholic fatty liver disease
... through de novo lipogenesis are the major sources of TAGs in the liver and are secreted as lipoproteins in NAFLD (see the related article beginning on page ...
5
Retinal de novo lipogenesis coordinates neurotrophic signaling to maintain vision
... Since several neurotrophic signaling pathways depend on membrane microdomain integrity and lipid ordering, properties that are crucially regulated by cholesterol (36), we examined neurotrophic responsive- ness in ...
16
Constitutive expression of microRNA 150 in mammary epithelium suppresses secretory activation and impairs de novo lipogenesis
... for de novo fatty acid synthesis (FASN, ACACA and OLAH) and cell survival (STAT5B) in mammary ...of de novo fatty acids is dramatically reduced, which affects fatty acid content and results in ...
13
A randomized 3-way crossover study indicates that high-protein feeding induces de novo lipogenesis in healthy humans
... The effect of increasing glutamine, leucine, and lysine concentrations on DNL synthesis, processing, and VLDL packaging gene expression in AML12 hepatocytes.. Data are presented as mean[r] ...
22
Clinical assessment of hepatic de novo lipogenesis in non-alcoholic fatty liver disease
... Lipidomics is the study of lipid species and their bio- logical roles, and this emerging field has advanced med- ical research. Often lipids are altered in a diseased state and novel lipid biomarkers can be useful for ...
10
Short term alterations in carbohydrate energy intake in humans Striking effects on hepatic glucose production, de novo lipogenesis, lipolysis, and whole body fuel selection
... Short-term alterations in dietary carbohydrate (CHO) energy are known to alter whole-body fuel selection in humans, but the metabolic mechanisms remain unknown. We used stable isotope-mass spectrometric methods with ...
10
Effects of a low fat, high carbohydrate diet on VLDL triglyceride assembly, production, and clearance
... from de novo lipogenesis to palmitate in VLDL-TG was also ...that de novo lipogenesis did not make a substantial contribu- tion of fatty acids (<5%) to fasting TG on either ...
11
Measurement of de novo hepatic lipogenesis in humans using stable isotopes
... from de novo lipogenesis was only ...Thus, de novo hepatic lipogenesis is a quantitatively minor pathway, consistent with gas exchange estimates; fatty acid futile cycling ...
13
The role of hepatic fat accumulation in pathogenesis of non-alcoholic fatty liver disease (NAFLD)
... DNL: de novo lipogenesis; NEFA: non-esterified fatty acids; LDL: very low density lipoproteins; TG: triglycerides; CVD: cardiovascular dis- ease; IFG: impaired fasting glucose; IGT: impaired glucose ...
9
Apolipoprotein A-IV involves in glucose and lipid metabolism of rat
... In consistent with an earlier study using ApoA-IV KO mice [11], we also found a significant increase in hepatic TG content in ApoA-IV KO rats. Hepatic steatosis arises from an imbalance between TG acquisition and removal ...
9
Amount of hepatic fat predicts cardiovascular risk independent of insulin resistance among Hispanic-American adolescents
... The liver plays a critical role in the biological process of VLDL assembly and secretion. Both hepatic steatosis [21,22] and insulin resistance [23] are known to be associated with increased large VLDL concentrations. ...
8
Imaging mass spectrometry demonstrates age-related decline in human adipose plasticity
... Quantification of stable isotope tracers has revealed the dynamic state of living tissues. A new form of imaging mass spectrometry quantifies isotope ratios in domains much smaller than a cubic micron, enabling ...
12
Effect of photoperiod on body mass, food intake and body composition in the field vole, Microtus agrestis
... We also demonstrated that fatty acid composition of subcutaneous fat depots in voles accumulating adipose tissue (days 1–28 of exposure to LD) was not significantly different from that in SD voles or LD voles during the ...
14
The origins, evolution, and functions of lineage-specific genes in Drosophila
... leading to the intriguing hypothesis that newer de novo genes might be less likely to be essential. Instead, as de novo genes age, they may begin to evolve new functions. All four of these ...
161
Tracing the De Novo Origin of Protein Coding Genes in Yeast
... ABSTRACT De novo genes are very important for evolutionary ...for de novo genes in Saccharomyces cerevisiae S288C and examined their spread and fixation in the ...84 de novo genes ...
11