Deacetylase activity
Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression
... inhibitory activity due to the accumulation of L -lactate and increasing ...histone deacetylase activity in vitro. The graph shows HDAC activity in ...
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Inhibition of Histone Deacetylase Activity Aggravates Coxsackievirus B3-Induced Myocarditis by Promoting Viral Replication and Myocardial Apoptosis
... FIG 1 Inhibition of HDAC activity exacerbates rather than attenuates CVB3-induced viral myocarditis. BALB/c mice were sham infected with PBS (control) or infected with CVB3 on day 0 and then treated (or not) with ...
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Podocyte histone deacetylase activity regulates murine and human glomerular diseases
... influenced by increased HDAC1 and HDAC2 activity, and poten- tially reversed by HDAC inhibitors. To test the potential effect of HDAC inhibitors, either of the FDA-approved drugs valproic acid (VPA) and ...
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Characterization of Inhibitor-Resistant Histone Deacetylase Activity in Plant-Pathogenic Fungi
... histone deacetylase (HDAC) from many ...HDAC activity in crude extracts of ...HDAC activity of Aspergillus nidulans is sensitive ...HDAC activity was present in other, but not all, ...
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Histone deacetylase activity has an essential role in establishing and maintaining the vertebrate neural crest
... HDAC activity and histone acetylation in the maintenance of pluripotency and the genesis of neural crest cells in ...HDAC activity is required for the formation of the neural crest and for the pluripotency ...
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Hypoxia inducible factor dependent histone deacetylase activity determines stem cell fate in the placenta
... HDACs belong to one of three classes that were first described in yeast (Kurdistani and Grunstein, 2003). Class I HDACs (HDAC1, HDAC2, HDAC3 and HDAC8) are ubiquitous regulators of transcription. Interestingly, HIF1 α ...
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Histone deacetylase activity mediates acquired resistance towards structurally diverse HSP90 inhibitors
... Central to its function, HSP90 contains an ATP- binding/ATPase activity domain within its N-terminal region (Jhaveri et al., 2012). Geldanamycin (GA), a member of the benzoquinone ansamycin (BA) family of ...
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Cryptococcus neoformans Cda1 and Its Chitin Deacetylase Activity Are Required for Fungal Pathogenesis
... cda1 ⌬ 2 ⌬ 3 ⌬ strain displayed a robust inflammatory response followed by complete clearance of fungal cells (41). This suggests that the ability of the fungal cells to convert chitin to chitosan is critical for masking ...
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Histone Deacetylase Activity Regulates Chemical Diversity in Aspergillus
... histone deacetylase (HDAC), causes transcriptional activation of two telomere-proximal gene clusters—and subsequent increased levels of the corresponding molecules (toxin and antibiotic)—but not of a ...
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Discovery and validation of SIRT2 inhibitors based on tenovin 6 : use of a 1H NMR method to assess deacetylase activity
... reduced activity against SIRT2 compared with tenovin-6 but was even less active against SIRT1 ...similar activity profile to tenovin-36 ...the activity and selectivity was retained and it was ...
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Histone Acetylation Level and Histone Acetyltransferase/Deacetylase Activity in Ejaculated Sperm from Normozoospermic Men
... A proportion of processed sperm was vitrified for the mea- surement of total HAT/HDAC activity. We performed a preliminary western blot assay from 5 men to verify the ex- pression of HAT/HDAC in mature human ...
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Histone deacetylase activity is decreased in peripheral blood monocytes in patients with COPD
... HDAC activity or serum CXCL8 ...HAT activity was not analyzed to determine whether the decreased HDAC activity was related to HAT ...HDAC activity of PBMC in non-smoking COPD ...
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Histone deacetylase-3 interacts with ataxin-7 and is altered in a spinocerebellar ataxia type 7 mouse model
... and deacetylase activity in a transgenic mouse model of SCA7 and found HDAC3 to be highly expressed in both neurons and glia in the cerebellum of nontransgenic and SCA7 transgenic ...
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Escape from Mitotic Arrest: An Unexpected Connection Between Microtubule Dynamics and Epigenetic Regulation of Centromeric Chromatin in Schizosaccharomyces pombe
... In this study, we further investigate our reported observa- tion that deletion of msc1 alleviates the cs lethality associated with dis1-288 (Qiu et al. 2010). Because Msc1 coprecipitates a histone deacetylase ...
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Plasmodium falciparum Sir2: an Unusual Sirtuin with Dual Histone Deacetylase and ADP-Ribosyltransferase Activity
... deacetylase activity. (A) Reaction scheme for NAD ⫹ -dependent deacetylase en- ...vitro deacetylase assays were carried out on increasing amounts of PfSir2, with or without 500 M NAD ⫹ ...
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The activities of protein kinase CK2 in oogenesis of `Xenopus laevis'
... Histone deacetylase activity is accumulated in Xenopus oocytes as protein complexes and is transported to the nucleus prior to maturation.. LLINAS*, JAMES RYAN*, DARREN A.[r] ...
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Histone deacetylase 6 activity is critical for the metastasis of Burkitt’s lymphoma cells
... tubulin deacetylase activity or HDAC6 itself binding to the micro- tubules, we tested the microtubule stability of HDAC6- depleted cells in cold-induced depolymerizing ...
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Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich’s ataxia cardiomyopathy model
... lase activity, contributing to the progressive hyperacetylation of mitochondrial proteins in this model ...SIRT3 activity in the FXN-KO heart (Supplemental Figure 1F; validated via qPCR in Figure ...SIRT3 ...
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Histone deacetylase 6 in cancer
... The interaction of HDAC6 with histone and nonhistone substrates (such as α-tubulin, HSP90, and cortactin) is in- volved in gene transcription, DNA damage repair, and cell movement. Once the expression level of HDAC6 ...
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Histone deacetylase 3, not histone deacetylase 2, interacts with the major immediate early locus of human cytomegalovirus
... Different cellular mechanisms have been found to play roles in inhibiting viral gene expression, and one of the most prominent ones is gene silencing through viral DNA chromatinization (also called chromatin remodel- ...
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