DEAD-box RNA helicase
Subsite-specific association of DEAD box RNA helicase DDX60 with the development and prognosis of oral squamous cell carcinoma
... of RNA helicases, with 37 members in humans ...synthesis, RNA splicing and modification, ribosome and spliceosome assembly, and the transcriptional regulation of the genes involved in DNA repair and ...
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The DEAD box RNA helicase Ddx39ab is essential for myocyte and lens development in zebrafish
... the DEAD-box RNA helicase family have been shown to be involved in nearly all aspects of RNA metabolism, from transcription to mRNA ...of DEAD-box RNA helicases in ...
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The DEAD box RNA helicase Vad1 regulates multiple virulence associated genes in Cryptococcus neoformans
... The study of fungal regulatory networks is essential to the understanding of how these pathogens respond to host environmental signals with effective virulence-associated traits. In this study, a virulence-associated ...
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Regulation of Notch Signaling by an Evolutionary Conserved DEAD Box RNA Helicase, Maheshvara in Drosophila melanogaster
... The putative Mahe protein contains a highly conserved signature motif DEAD, which is the hallmark of the DEAD box RNA helicase family. Swiss model 2.0 was used for prediction of ...
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Centroid, a novel putative DEAD box RNA helicase maternal mRNA, is localized in the mitochondrial cloud in Xenopus laevis oocytes
... of RNA metabolism such as transcription, RNA splicing, ribosome bio- genesis, translation initiation and RNA transport and degradation and are found in all eukaryotes and most prokaryotes (Cordin et ...
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The Sole DEAD Box RNA Helicase of the Gastric Pathogen Helicobacter pylori Is Essential for Colonization
... of DEAD-box helicases in ...minimal RNA degradosome in ...identified DEAD-box RNA helicase that we designated RhpA ...the DEAD-box helicases among the ...sole ...
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DDX3 DEAD-Box RNA Helicase Inhibits Hepatitis B Virus Reverse Transcription by Incorporation into Nucleocapsids
... Experimental strategy. To search for host factors that bind to HBV Pol, we utilized affinity purification of HBV Pol fol- lowed by mass spectrometry to identify copurified host factors. A cell line that stably expresses ...
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SpolvlgA is a DDX3/PL10-related DEAD-box RNA helicase expressed in blastomeres and embryonic cells in planarian embryonic development
... Planarian flatworms have an impressive regenerative power. Although their embryonic de- velopment is still poorly studied and is highly derived it still displays some simple character- istics. We have identified ...
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Conserved requirement for DEAD box RNA helicase Gemin3 in Drosophila oogenesis
... The DEAD-box RNA helicase Gemin3 (also referred to as DP130 or DDX20) is a core member of the SMN (survival of motor neurons) complex ...other DEAD-box family members within the ...
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DDX3 DEAD-Box RNA Helicase Is a Host Factor That Restricts Hepatitis B Virus Replication at the Transcriptional Level
... HBV RNA via transcriptional regula- ...viral RNA synthesis by suppressing ...HBV RNA synthesis by ...the helicase motif are denoted, along with the DEAD ...the helicase motif of ...
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A HIV 1 Tat mutant protein disrupts HIV 1 Rev function by targeting the DEAD box RNA helicase DDX1
... Importantly, RNA polymerase II-directed tran- scription from the CMV promoter in this construct is only minimally affected by Tat and Nullbasic, thereby allowing the segregation of Tat’s role in transactivation ...
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Involvement of a Toxoplasma DEAD-box RNA Helicase in Post-transcriptional Gene Regulation
... DEAD-box RNA helicases were first described by Gorbalenya et ...then, DEAD-box RNA helicases have been classified as the largest helicase family of ...of RNA ...
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DDX3 DEAD-Box RNA Helicase Is Required for Hepatitis C Virus RNA Replication
... double-stranded RNA and separate the RNA strands or might contribute to the function of HCV NS3 ...replicon RNA was also partially suppressed in DDX3 knockdown cells ...fering RNA-mediated ...
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Identification of the DEAD box RNA helicase DDX3 as a therapeutic target in colorectal cancer
... Different levels of interference have been suggested for DDX3 in the Wnt-signaling pathway. In contrast with our findings, Cruciat, et al. found that DDX3 inhibition had no effect on Wnt signaling activity after ...
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The DEAD box RNA helicase Vasa functions in embryonic mitotic progression in the sea urchin
... Its DEAD-box motif, its physical interaction with eIF5B and the observation that several proteins do not accumulate in Vasa-mutant flies suggests that it functions in translational regulation (Linder, 2003; ...
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An Essential Role for the Saccharomyces cerevisiae DEAD-Box Helicase DHH1 in G1/S DNA-Damage Checkpoint Recovery
... a DEAD-box RNA helicase orthologous to the human putative proto-oncogene p54/RCK, is important in release from DNA-damage-induced cell cycle arrest at the G1/S ...
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The QRxGRxGRxxxG motif of the vaccinia virus DExH box RNA helicase NPH-II is required for ATP hydrolysis and RNA unwinding but not for RNA binding.
... GxGKT box, the Glu and Asp moieties just downstream of the DExH box, and various constituents of the QRxGRxGRxxxG motif (see ...DNA helicase (27), the potyvirus C1 RNA helicase (12), ...
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Characterization of Selected Transposon-mediated Mutants of Listeria monocytogenes Regarding Survival and Growth on Cantaloupe.
... DEAD-box RNA helicases are highly conserved with 12 characteristic sequence motifs present in all eukaryotic cells and many bacteria (Markkula et ...2014). DEAD-box proteins get their ...
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Unexpected roles for DEAD box protein 3 in viral RNA sensing pathways
... viral RNA in the ...the DEAD (Asp-Glu-Ala- Asp) box helicase DDX3 (DEAD/H Box 3), known for some time to have a number of roles in cellular RNA regulation in the nucleus, ...
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Mutational analysis of vaccinia virus nucleoside triphosphate phosphohydrolase II, a DExH box RNA helicase.
... DExH box of NPH-II is to constitutively activate NTPase, without need for a nucleic acid ...or DEAD protein). The H299A mutant can bind stably to RNA, and yet its ATPase is not stimulated apprecia- ...
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