Death receptor 5
Preparation and functional studies of hydroxyethyl chitosan nanoparticles loaded with anti-human death receptor 5 single-chain antibody
... Materials and methods: The anti-human death receptor 5 single-chain antibody was con- structed and expressed. Protein-loaded hydroxyethyl chitosan nanoparticles were prepared, and their size, ...
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The Apoptotic Effect of the Methanol Extract of Polygonum cuspidatum through Up Regulation Death Receptor 5 and CHOP in HSC 2 Human Oral Cancer Cells
... Polygonum cuspidatum is used as a traditional medicinal herb for the therapy of various diseases including several types of cancers. In the present study, we focused on addressing the anti-cancer activity and molecular ...
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Synthetic ligands of death receptor 5 display a cell-selective agonistic effect at different oligomerization levels
... (Death Receptor 4) and DR5 (Death Receptor 5) are two potential targets for cancer therapy due to their ability to trigger apoptosis of cancer cells, but not normal ones, when activated ...
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Suppression of death receptor 5 enhances cancer cell invasion and metastasis through activation of caspase-8/TRAF2- mediated signaling
... of death receptor 5 (DR5), a well-known cell surface pro-apoptotic protein, in the negative regulation of invasion and metastasis of human cancer cells and the underlying mechanisms are largely ...
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In Vitro and In Vivo Evaluation of 89Zr-DS-8273a as a Theranostic for Anti-Death Receptor 5 Therapy
... anti-human death receptor 5 (DR5) agonistic antibody, has cytotoxic activity against human cancer cells and induces apoptosis after specific binding to ...DR5 receptor saturability in a mouse ...
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The enhanced expression of death receptor 5 (DR5) mediated by HBV X protein through NF kappaB pathway is associated with cell apoptosis induced by (TNF α related apoptosis inducing ligand) TRAIL in hepatoma cells
... Human hepatocarcinoma cell line Huh-7 cell, obtained from the Cell Bank of Chinese Academy of Sciences, was cultured in DMEM supplemented with 10 % fetal bovine serum (FBS) at 37 °C in 5 % CO2. Huh-7 cells ...
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The novel proteasome inhibitor carfilzomib activates and enhances extrinsic apoptosis involving stabilization of death receptor 5
... through death receptors and the intrinsic apoptotic pathway that largely relies on signals from the ...surface death receptors and activation of caspase-8, while the intrinsic pathway involves the ...
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Gefitinib upregulates death receptor 5 expression to mediate rmhTRAIL-induced apoptosis in Gefitinib-sensitive NSCLC cell line
... cell death induced by gefitinib, rmhTRAIL, or the combination of ...cell death as verified by the results obtained from MTT assay and the assessment of sub-G1 cells by flow ...
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TRAIL induces apoptosis in oral squamous carcinoma cells: a crosstalk with oncogenic Ras regulated cell surface expression of death receptor 5
... As with many other cancer types, the development of oral cancer is often accompanied by an upregulated Ras signaling pathway due to gain of function mutations in ras genes itself and/or alterations in the regulatory ...
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Transformation of SV40-immortalized human uroepithelial cells by 3-methylcholanthrene increases IFN- and Large T Antigen-induced transcripts
... TRICK2A: death receptor 5 or DR5 (also Apo2; TRAIL-R2; TRICK2; or KILLER); IAP3: inhibitor of apoptosis protein 3; HSIAH2: inhibitor of apoptosis protein 2; IRRP + DAP1: death-associated ...
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Pregnane X receptor activation potentiates ritonavir hepatotoxicity
... cell death and tissue injury, including death receptor 5 (Dr5), BCL2-associated X (Bax), and monocyte chemoattractant protein 1 (Mcp1) in the liver of hPXR/CYP3A4 mice pretreated with RIF for ...
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The flavokawains: uprising medicinal chalcones
... the death-receptor and mitochondrial-mediated apoptotic me- chanism ...of death receptor 5, Bim and Puma were up-regulated while the expression of survivin, an anti-apoptotic protein ...
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Nanomedicine and cancer immunotherapy: focus on indoleamine 2,3-dioxygenase inhibitors
... dioxygenase (IDO) enzymatic activity contributes to interferon-gamma induced apoptosis and death receptor 5 expression in human non- small cell lung cancer cells. Asian Pac J C[r] ...
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Binding of Typical and Atypical Antipsychotic Agents.pdf
... Although 5-HT6 or 5-HT receptor affinity alone does not prediCt whether or not a drug will have atypical antipsychoc actMty, the relatively high affinity of the 5-HT receptor for several[r] ...
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Original Article Dihydroartemisinin and cisplatinum synergistically induced apoptosis in human lung adenocarcinoma H1299 cells
... caspase-8-related death recep- tor signaling pathway and the caspase-9-related mitochondrial signaling pathway may play important roles in the synergistic effect of DHA and ...the death receptor and ...
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Original Article Vagus nerve stimulation causes wake-promotion by affecting neurotransmitters via orexins pathway in traumatic brain injury induced comatose rats
... Glutamate, 5-HT, DA, His could promote wakefulness, on the con- trary, inhibitory neurotransmitter such as GABA could promote sleeping [4, ...of 5-TH ...NMDAR1, 5-HT 2A R, H1R, α1-AR ...
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Paroxysmal hypnogenic dyskinesia is associated with mutations in the PRRT2 gene
... Clinical presentation of the patients with PRRT2 mutations. Patient 1 was a 24-year-old man who presented with episodic dyskinesia since the first year of life. He experienced ballistic or choreoathetoid attacks while ...
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Original Article Oxidative stress pathways of flavonoid toxicity in human breast tumor cells
... Abstract: African-American women have a higher breast cancer mortality rate than Caucasian women. Harmful re- active oxygen species (ROS) exert oxidative stress in cells of the human body and lead to several types of DNA ...
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<p>Use of Programmed Death Receptor-1 and/or Programmed Death Ligand 1 Inhibitors for the Treatment of Brain Metastasis of Lung Cancer</p>
... Use of atzolizumab was approved by the FDA as a second-line therapy based on the fi ndings from a phase II clinical trial, and was veri fi ed in the OAK III clinical trial. Compared with docetaxel, atzolizumab showed ...
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Sequence and translation initiation properties of the xenopus TGFbeta5, PDGF A, and PDGF alpha receptor 5' untranslated regions
... these 5’UTRs could be a temporal or spatial relief of their moderate inhibitory potential, as shown for the antennapedia and ultrabithorax 5’UTRs in Dro- sophila development (Ye et ...expressing ...
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