Definition of Structural Identifiability: Mixed-Effects Models 71
Structural Properties of Dynamic Systems Biology Models: Identifiability, Reachability, and Initial Conditions
... of identifiability for particular x 0 can also happen in uncontrolled models such as Example 4, which are by definition unreachable and for which the dimension of ∆ c is always ...general, ...
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Input dependent structural identifiability of nonlinear systems
... once structural identifiability has been guar- anteed by taking into account the aforementioned issues (a, b, c), a full experiment definition still requires deciding on other aspects, such as the ...
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Structural identifiability analysis via symmetries of differential equations
... of models (for ex- ample nonlinear state space models) might be classified by the Lie algebras that act upon the observation in a trivial ...hence structural identifiability analysis could be ...
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Structural identifiability and indistinguishability in mixed effects models
... There are a several advantages of using mathematical modelling when devel- oping new pharmaceutical drugs. Firstly, modelling can be used to characterise the properties of a drug. With the use of modelling and ...
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Structural identifiability in mixed effects models : two different approaches
... Abstract: Structural identifiability analysis is a theoretical concept that ascertains whether unknown model parameters can be uniquely determined for a given experimental ...Therefore, structural ...
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Extending existing structural identifiability analysis methods to mixed effects models
... of structural identifiability for state-space models is expanded to cover mixed-effects state-space ...the structural identifiability of mixed-effects ...
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Structural identifiability for mathematical pharmacology : models of myelosuppression
... four models are identifiable under certain simplifying ...the models and some empirical observations of parameter estimation ...specific effects of treatments as ...
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Structural identifiability and indistinguishability analyses of glucose insulin models
... time-varying effects, involving different levels of the hierarchy of molecules, cells, organs and organisms and in most cases, the measurements obtained generally do not directly give information on the targeted ...
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Identifiability of Finite Mixtures of Multinomial Logit Models with Varying and Fixed Effects
... fixed effects for the coefficients of the covariates: Coefficients of varying effects follow a finite mixture, ...fixed effects are constant over the whole population. This is similar to ...
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Parameter identifiability of fundamental pharmacodynamic models
... the mixed effects models. b Each mixed-effects model was assumed to have a diagonal covariance matrix with lognormally distributed random ...the structural ...
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Mixed Structural Models for 3D Audio in Virtual Environments
... the effects of visual distraction (Secoli et ...the definition of an effective auditory display for con- veying informative content to the user during target following ...
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Conditional Akaike information for mixed-effects models
... In addition, the can compare nonnested models. When the model under consideration contains random e ffects, the definition of the is not straightforward. What likelihood should be used? Should the random ...
Including phenotypic causal networks in genome-wide association studies using mixed effects structural equation models
... Momen, Mehdi; Mehrgardi, Ahmad Ayatollahi; Roudbar, Mahmoud Amiri; Kranis, Andreas; Pinto, Renan Mercuri; Valente, Bruno D.; Morota, Gota; Rosa, Guilherme J.M.; and Gianola, Daniel, "[r] ...
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FIXED AND MIXED-EFFECTS MODELS FOR MULTI-WATERSHED EXPERIMENTS
... Therefore, a further refinement to the model was needed. The term c ij was redefined as the proportion of area harvested in water years prior to storm j. In a Mediterranean climate, the water year begins at the start of ...
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Structural identifiability of large systems biology models
... 3.4. C ONCLUSIONS In this paper, we introduce an efficient method to reparameterise large structurally uniden- tifiable models. Our hybrid method starts with a numerical identifiability analysis. This ...
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Structural identifiability of equivalent circuit models for Li Ion batteries
... Abstract: Structural identifiability is a critical aspect of modelling that has been overlooked in the vast majority of Li-ion battery modelling ...ascertain structural identifiability are ...
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Structural identifiability analyses of candidate models for in vitro Pitavastatin hepatic uptake
... 512996. models are proposed to characterise the uptake ...the models derived, as in most biomedical systems modelling, the model parameters have biological meaning and it is desired to establish whether it ...
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On the definition and identifiability of the alleged “hiatus” in global warming
... The second question pertains to the broader implications of this apparent discord between data and the discussion in the literature. We suggest that discussing climate change using the terms “pause” or “hiatus” creates ...
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Identifiability and Minimality in Rational Models
... The effects of such an application allowed us to characterize rational matrix models, study the possible pairs of minimum orders, recognize the exchangeable mod- els that might exist and detect identifiable ...
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Structural identifiability of polynomial and rational systems
... of structural algebraic controllabil- ity, structural algebraic observability, and structural canonicity by a slight modification of the corresponding notions for polynomial and rational sys- tems ...
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