Delayed-type hypersensitivity (DTH) response to
Role for Macrophage Inflammatory Protein 2 (MIP-2), MIP-1α, and Interleukin-1α in the Delayed-Type Hypersensitivity Response to Viral Antigen
... Passive transfer of antibodies to MIP-2 and MIP-1 ␣ sup- presses DTH and neutrophil accumulation. Neutralizing anti- body to individual chemokines was administered locally ad- mixed with virus challenge antigen in order ...
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CCR6 deficient mice have impaired leukocyte homeostasis and altered contact hypersensitivity and delayed type hypersensitivity responses
... the differences observed in lymphocyte subsets in CCR6 –/– mice. In addition, migration may be impaired in these CCR6 –/– cells, contributing to the overall defect. The altered responses observed in the CHS and DTH ...
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Multi-Scale Optical Imaging of the Delayed Type Hypersensitivity Reaction Attenuated by Rapamycin
... the delayed intense reaction, and this process is critical for initiating a full DTH response ...immune response with apparent edema from 24 h to 72 h ...cell response via the increased IFN- γ ...
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Pathogenesis and diagnosis of delayed-type drug hypersensitivity reactions, from bedside to bench and back
... immune response unless the immune sys- tem detects ‘danger’ [22, ...immune response, resulting in amplification of insufficient stimuli over a critical threshold, thereby ena- bling DTH to occur ...in ...
10
Spontaneous virologic suppression in HIV controllers is independent of delayed-type hypersensitivity test responsiveness
... testing despite having CD4 cell counts ≥ 400 cells/uL. This suggests that factors contributing to virologic con- trol and DTH responsiveness do not completely overlap. We previously showed that a favorable CCL3L1-CCR5 ...
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Human Immunodeficiency Virus Status and Delayed-Type Hypersensitivity Skin Testing in Ugandan Children
... When generalizing our conclusions to other HIV- infected pediatric populations, these factors must be considered. In our study of HIV-1-infected children, multiple factors affected DTH skin testing response, ...
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Schistosoma japonicum HSP60 derived peptide SJMHE1 suppresses delayed type hypersensitivity in a murine model
... induced a strong effect to prevent the development of DTH (Fig. 1a). Local cytokine production in the DTH ears was mea- sured to analyse further the in vivo immune suppression induced by SJMHE1. The ears were removed and ...
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Establishment and characterization of a sustained delayed type hypersensitivity model with arthritic manifestations in C57BL/6J mice
... inflammatory response to an antigen unrelated to the joint [30], the hypothesis being that joint auto-antigens are exposed to or released from the inflamed joint during the inflammatory response follow- ing ...
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Performance of Antigens Used in Detecting Delayed-Type Hypersensitivity in Adolescents Infected with the Human Immunodeficiency Virus
... subject response to DTH antigens, and it is probable that CD4 ⫹ T-cell count alone does not fully explain the occurrence of anergy that may result from immu- nologic dysfunction operating before the decline of ...
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Staphylococcal lipoteichoic acid inhibits delayed type hypersensitivity reactions via the platelet activating factor receptor
... The mechanism by which PAF-R activation could result in an inhibition of DTH responses was also explored. Since PAF-R acti- vation has been shown to stimulate production of the potent Th2 cytokine IL-10 in the murine ...
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Sensitization with atypical mycobacteria is a potent risk factor for cross-reaction with the delayed type hypersensitivity assay in mice
... immune response that would produce a delayed-type hypersensitivity ...immune response in the draining lymph nodes generated by PPD administration, repeated sensitizations do not elicit ...
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Evaluation of Recombinant Mycobacterium tuberculosis Antigens MPT64, CFP10, and ESAT6 for Delayed Type Hypersensitivity Responses in Guinea Pigs
... In this report, we produced purified recombinant proteins rMPT64, rCFP10, and rESAT6 and used them as an- tigens to stimulate DTH responses in guinea pigs. Our results showed that the purified recombinant proteins were ...
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Iron oxide nanoparticles suppressed T helper 1 cell-mediated immunity in a murine model of delayed-type hypersensitivity
... on the functionality of both macrophages and Th1 cells by systemically administered iron oxide nanoparticles. These results suggest that the way of administration may be a critical factor influencing the immunomodulatory ...
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Antibody and delayed-type hypersensitivity responses to Ochrobactrum anthropi cytosolic and outer membrane antigens in infections by smooth and rough Brucella spp.
... DISCUSSION The results presented show that an immune response to O. anthropi antigens is consistently elicited by experimental and natural infections with B. ovis, B. melitensis, and B. abortus in a variety of ...
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Characterisation of the B-lymphocyte response in delayed-type piperacillin hypersensitivity reactions.
... drug hypersensitivity requires a multidisciplinary approach that relates immune responses to clinical outcome using samples obtained prior to a reaction, in the acute phase and longitudinally as the patient ...
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Intermittent Fasting Ameliorates Delayed Type Hypersensitivity in NC/Nga Mice
... Received January 15 th , 2011; revised February 13 th , 2011; accepted March 17 th , 2011. ABSTRACT It is well documented that dietary restriction can prevent many different diseases and extend the life spans of ...
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Cysteine-type cathepsins promote the effector phase of acute cutaneous delayed-type hypersensitivity reactions
... CA-074 binds to the active site and occludes the loop of cathepsin B [61]. CA-074 inhibits cathepsin B most effectively at acidic pH, which is common in lysosomes [62]. The anionic CA-074 molecule was thought to be ...
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Specific Delayed Type Hypersensitivity Responses to ESAT 6 Identify Tuberculosis Infected Cattle
... substantial delayed-type hypersensitivity ...test response differed for the two reagents; PPD showed maximal response at 72 h, but the response to ESAT-6 often peaked later at 96 ...
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Case Report of Subcutaneous Nodules and Sterile Abscesses Due to Delayed Type Hypersensitivity to Aluminum-Containing Vaccines
... Intramuscular injection of aluminum, a common adjuvant in inactivated vaccines and in allergen immunotherapy leaves a “depot” of antigen, prolonging exposure to antigen presenting cells and improving host immunologic ...
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Studies on delayed-type hypersensitivity
... from the peritoneal exudates of hypersensitive guinea pigs injected with antigeno These findings, together with the occurrenc e of cell clumping, suggested that th [r] ...
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