Dendritic cells and tolerance
Oral tolerance and OVA-induced tolerogenic dendritic cells reduce the severity of collagen/ovalbumin-induced arthritis in mice
... Dendritic cells play a fundamental role in the establishment of the peripheral tolerance ...splenic cells stimulated in vitro with ...Spleen cells from arthritic mice adoptively ...
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Plasmacytoid Dendritic Cells Are Key Regulators of Immune Tolerance
... Figure 1.5 pDC regulate anti-tumor immunity and can promote tumor escape. A, pDC are recruited into the tumor microenvironment via multiple receptor–ligand interactions. Interaction of stromal cell-derived factor-1/ ...
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Specialized role of migratory dendritic cells in peripheral tolerance induction
... Harnessing DCs for immunotherapies in vivo requires the elucidation of the physiological role of distinct DC populations. Migratory DCs traffic from peripheral tissues to draining lymph nodes charged with tis- sue self ...
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The influence of dendritic cells on tolerance induction to circulating and extrathymic proteins.
... DP. Tolerance induction is still complete at the ratio of 1 DC: 80 thymocytes, since no mature C5 reactive cells could be detected in a functional assay in vitro (data not ...CD4 cells from a control ...
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The IL-12 family and dendritic cells : key regulators of immunity and immunological tolerance
... regulation (chapter 4). fH and fP are at opposite poles in terms of complement regulation with fH being an important negative regulator and fP being the only know positive regulator within the entire system. ...
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Targeting DEC-205−DCIR2+ dendritic cells promotes immunological tolerance in proteolipid protein-induced experimental autoimmune encephalomyelitis
... Conclusion In summary, our results indicate that using antibodies other than αDEC-205 to target various subsets of conven- tional DCs can lead to amelioration of EAE. αDCIR2-PLP fusion mAbs are able to induce expansion ...
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Barthels, Christian (2016): CD40 signaling in dendritic cells modulates tolerance and immunity. Dissertation, LMU München: Medizinische Fakultät
... between cells in gut and ...These cells, although CD11b + , are probably not inflammatory DCs, because those have been reported to be also positive for F4/80 and CD64 and all cells considered to be ...
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Original Article Induction of immune tolerance to rat liver allograft by sTNFRI-IgGFc and CCR7 gene modified immature dendritic cells
... If the donor imDC can be modified by the fac- tors that could inhibit the maturation and acti- vation of DC, its immunogenicity would be reduced and the tolerant activation would be increased, and it would be maintained ...
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SOCS1 restricts dendritic cells’ ability to break self tolerance and induce antitumor immunity by regulating IL 12 production and signaling
... break tolerance against self tumor-associated ...T cells but rarely causes autoimmune pathologies, indicating that self tolerance at the host level is still maintained in the vaccinated ...self ...
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Cells of the synovium in rheumatoid arthritis Dendritic cells
... T cells into the periphery, where subsequent genetic or environmental proinflammatory events more readily trigger the priming of these T cells and the development of autoimmune disease ...T cells, in ...
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Update on Dendritic Cell-Induced Immunological and Clinical Tolerance.
... blood dendritic cells antigen; DNGR-1, dendritic cell natural killer lectin group receptor-1; IFN, interferon; ILT, immunoglobulin-like transcript; Lin, lineage; MHC II, major histocompatibilty ...
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Role of dendritic cells in the induction of regulatory T cells
... central tolerance, peripheral tolerance is mediated by DCs through generation of Tregs and clo- nal deletion of self reactive T ...Th3 cells and double negative ...
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Dendritic cell and macrophage-mediated tolerance in lupus-prone mice
... B cells in the ...B cells are not in the proper location in the spleen to be regulated by extrinsic tolerance mechanisms other than IL-6, CD40L, and TNF ...B cells are not able to receive ...
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Dendritic cells in intestinal homeostasis and disease
... Maria Rescigno 1 and Antonio Di Sabatino 2 1 Department of Experimental Oncology, European Institute of Oncology, Milan, Italy. 2 First Department of Medicine, S. Matteo Hospital, University of Pavia, Pavia, Italy. DCs ...
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Ontogeny and function of dendritic cells in childhood
... from tolerance to immune responsiveness, therefore the right balance must be struck to minimise any with potential detrimental effects on the development of the neonatal immune ...
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Dendritic Cells and Macrophages: Sentinels in the Kidney
... T cells to undergo ...peripheral tolerance, which serves as a sec- ond checkpoint (after thymic tolerance) against T-cell responses against autoantigens that are usually devoid of PAMPs ...
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Dendritic cell-derived nitric oxide inhibits the differentiation of effector dendritic cells
... promotes pathogen clearance and can also result in tissue damage. Regulatory DCs, in contrast, contribute to immune tolerance by triggering T cell apoptosis or anergy or inducing Treg differentiation via the ...
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mTOR inhibitors effects on regulatory T cells and on dendritic cells
... T cells, the association with post-transplant proteinuria and new onset diabetes after transplant ...allograft tolerance. Impor- tantly, transplant tolerance is expected to reduce rejec- tion while ...
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Analysis of proteomic profiles and functional properties of human peripheral blood myeloid dendritic cells, monocyte derived dendritic cells and the dendritic cell like KG 1 cells reveals distinct characteristics
... Background Dendritic cells (DCs) are highly specialized antigen present- ing cells that originate from bone marrow progenitor ...with cells of the adap- tive immune system (for example, T ...
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Targeting dendritic cells in pancreatic ductal adenocarcinoma
... Abstract Dendritic cells (DC) are an integral part of the tumor microenvironment. Pancreatic cancer is characterized by reduced number and function of DCs, which impacts antigen presentation and contributes ...
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