Dendritic spine
Modulation of dendritic spine development and plasticity by BDNF and vesicular trafficking: fundamental roles in neurodevelopmental disorders associated with mental retardation and autism
... Reduced dendritic tree size and complexity in pyramidal cells was observed in the frontal and motor cortices and in the subiculum, the main output region of the hippocampal formation ...reduced dendritic ...
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Automated 4D analysis of dendritic spine morphology: applications to stimulus-induced spine remodeling and pharmacological rescue in a disease model
... on spine morphology in live neu- rons (Figure ...increased dendritic spine head volume by ~150% within 25 minutes ...on dendritic spine ...3c). Spine classification ana- lysis ...
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Computational Approach to Dendritic Spine Taxonomy and Shape Transition Analysis
... Understanding dendritic spine shape taxonomy and shape transitions upon synaptic potentiation is of great ...of dendritic spine morphological changes is to categorize the spines into ...
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Dendritic Spine Pathology in Infants With Severe Protein-Calorie Malnutrition
... normal infants (NI) were striking in the three cortical areas studied. The average length of the apical den- drites was 846.43 m m 6 46.09 in NI, whereas in MI the average was 581.54 m m 6 54.32 (P , .001) (Fig 1). The ...
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From neurodevelopment to neurodegeneration: the interaction of neurofibromin and valosin-containing protein/p97 in regulation of dendritic spine formation
... To further elucidate the role of the neurofibromin-VCP interaction in NF1 and IBMPFD, the influence of muta- tions in the genes identified in patients has been investi- gated. The neurofibromin mutant (Y1587delta) ...
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Intracellular amyloid β oligomers impair organelle transport and induce dendritic spine loss in primary neurons
... compromise dendritic spine maturation and ...reduce spine density and alter morphology by at least two mechanisms: one is the mis- localization of p21-activated kinase (PAK), and another is the ...
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Neuroplasticity of the dendritic spine : early dysfunction in amyotrophic lateral sclerosis
... An EC Plan-Neofluar 10x/0.3 air objective (Nikon, USA) was used to image the vasculature of a region of interest (ROI), illuminated by white light, and captured using XCAP Image Processing Software (EPIX Incorporated, ...
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Docosahexaenoic acid (DHA): a modulator of microglia activity and dendritic spine morphology
... postsynaptic dendritic spines is currently ...on dendritic spines, the postsynaptic structural components found on exci- tatory synapses of principal neurons in the brain ...
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Valosin containing protein and neurofibromin interact to regulate dendritic spine density
... mammals, dendritic spines are the locations of more than 90% of excitatory synapses (1) and therefore constitute the functional subcellular structures for excitatory neurotransmission ...of dendritic ...
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Mechanistic target of rapamycin is necessary for changes in dendritic spine morphology associated with long-term potentiation
... in dendritic spine head width at any time point assessed ...control. Spine heads treated with 10 μM glycine alone (595 spines across 8 neurons) were not sig- nificantly different from vehicle treated ...
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The role of heparan sulfate deficiency in autistic phenotype: potential involvement of Slit/Robo/srGAPs-mediated dendritic spine formation
... small guanine triphosphatase activating proteins, which act on the Rho GTPase family [52]. Rho GTPase family members include Rac, Cdc42 and Rho, all of which are members of the RAS superfamily [53–55]. srGAPs are ...
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Computational investigation of Amyloid-β-induced location- and subunit-specific disturbances of NMDAR at hippocampal dendritic spine in Alzheimer's disease
... There are two types of glutamate receptors in the pyramidal neurons of the hippocampus: the N-methyl-D-aspartate receptor (NMDAR) and the α-amino-3-hydroxy-5-methyl-4-isoxa- zolepropionic acid receptor (AMPAR) at the ...
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The microtubule modulating drug Epothilone D alters dendritic spine morphology in a mouse model of mild traumatic brain injury
... Dendritic spine loss is a characteristic feature of a variety of diseases and injuries of the nervous system (Fiala et ...of dendritic spines (Matus, 2000; Hotulainen and Hoogenraad, 2010; Lei et ...
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Modelling and investigation of NMDAR-mediated calcium signalling at Hippocampal Dendritic Spine in Alzheimer’s disease
... We simulate conditions that alter the availability of different types of synaptic NMDAR and in the ratio of NR2A- to NR2B-NMDAR and analyse their effects on the Ca 2+ response and Ca[r] ...
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VPS35-deficiency results in an impaired AMPA receptor trafficking and decreased dendritic spine maturation
... the spine density labeled by GFP-GluA1 puncta was also less in VPS35-deficient neurons ...impaired spine maturation. However, this spine deficit was not obvious in VPS35 +/m neurons ex- pressing ...
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Amyotrophic lateral sclerosis mutant TDP 43 may cause synaptic dysfunction through altered dendritic spine function
... 10 DIV cortical pyramidal neurons. Although it is difficult to determine the stage of disease in ALS patients to which cultured primary neurons correspond, and investigation of earlier or later time-points is technically ...
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Kurz, Thorben Andreas (2012): Development of techniques for single dendritic spine analysis: spinomics. Dissertation, LMU München: Fakultät für Biologie
... as dendritic structure could only be identified in 18 out of 28 samples, this kind of screening method, albeit fast, is not suitable for determining if the staining worked or ...
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Computational investigation of Amyloid-β-induced location- and subunit-specific disturbances of NMDAR at hippocampal dendritic spine in Alzheimer's disease
... β-Amyloid 25-35 inhibits glutamate uptake in cultured neurons and astrocytes: modulation of uptake as a survival mechanism. Neurobiology of disease[r] ...
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ICAM5 as a Novel Target for Treating Cognitive Impairment in Fragile X Syndrome
... (FMRP). Spine dysgenesis and cognitive impairment have been extensively characterized in FXS; however, the underlying mechanism remains poorly ...of spine maturation, intercellular adhesion molecule 5 ...
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Specific cytoarchitectureal changes in hippocampal subareas in daDREAM mice
... Change in intracellular free calcium concentration has long been recognized as a universal signal underlying neuronal plasticity and adaptive responses in the CNS to different environmental stimuli [1, 2]. Diverse ...
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