Dependent rna-polymerase
Beclabuvir can inhibit the RNA-dependent RNA polymerase of newly emerged novel coronavirus (SARS-CoV-2)
... Recent emergence of novel coronavirus (SARS-CoV-2) all over the world has resulted more than 33,106 global deaths. To date well-established therapeutics modules for infected patients are unknown. In this present ...
20
Norovirus Proteinase-Polymerase and Polymerase Are Both Active Forms of RNA-Dependent RNA Polymerase
... viral RNA-dependent RNA polymerase (RdRp) domains: ProPol (a precursor comprised of both the proteinase and polymerase) and Pol (the mature ...
11
Enhancement of RNA Interference Effect in P19 EC Cells by an RNA-dependent RNA Polymerase
... endogenous RNA (pSUPER) system that directs the synthesis of siRNA-like ...enzyme, RNA-dependent RNA polymerase (RdRP), and is believed to be the reason behind the amplification effect ...
7
Two Membrane-Associated Regions within the Nodamura Virus RNA-Dependent RNA Polymerase Are Critical for both Mitochondrial Localization and RNA Replication
... positive-strand RNA genomes amplify their genomes in replication complexes associated with cellular ...establishes RNA replication complexes that associate with mitochondria in mammalian ...virus ...
15
Proteinase-Polymerase Precursor as the Active Form of Feline Calicivirus RNA-Dependent RNA Polymerase
... (FCV) RNA-dependent RNA polymerase ...proteinase- dependent processing of Pro-Pol in the interdomain region preceding Val-1235 was not observed in the presence of a catalytically active ...
9
Synthesis of novel products in vitro by an RNA-dependent RNA polymerase.
... RNA-dependent RNA polymerase from turnip crinkle virus-infected turnip transcribes both strands of a virus-associated satellite RNA, sat-RNA C (356 bases), in ...minus-strand ...
9
Association of the Influenza A Virus RNA-Dependent RNA Polymerase with Cellular RNA Polymerase II
... that RNA polymer- ase II (Pol II) transcription and RNA processing are coupled in vivo (11, 12, ...and RNA processing are influenced not only by cellular factors such as CTD kinases and phosphatases ...
7
Influenza A virus RNA-dependent RNA polymerase: analysis of RNA synthesis in vitro.
... virus RNA-dependent RNA polymerase, purified from virion ribonucleoprotein particles and from which endogenous genomic RNA (vRNA) has been depleted by treatment with micrococcal ...
9
Infectious Bursal Disease Virus Capsid Protein VP3 Interacts both with VP1, the RNA-Dependent RNA Polymerase, and with Viral Double-Stranded RNA
... double-stranded RNA (dsRNA) virus of the Birnaviridae ...viral RNA-dependent RNA polymerase, VP1, in a single-shell capsid that is composed of VP2 and ...
11
The Crystal Structure of a Cardiovirus RNA-Dependent RNA Polymerase Reveals an Unusual Conformation of the Polymerase Active Site
... picornaviral RNA-dependent RNA polymerase (RdRp) 3D pol , responsible for RNA genome replication, has been exten- sively studied, and there is a growing body of information avail- able ...
13
Characterization of an RNA-dependent RNA polymerase activity associated with measles virus.
... Figure 1.35 1.30 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest RESULTS The Edmonston B strain of measles virus grown in Vero cells showed RNA-dependent RNA polymerase[r] ...
7
RNA-Dependent RNA Polymerase in Nuclei of Cells Infected with Influenza Virus
... In this communication we describe the appearance and properties of RNA-dependent RNA polymerase activity in nuclei of cells infected with influenza virus, and compare the characteristics[r] ...
11
Rational Attenuation of a Morbillivirus by Modulating the Activity of the RNA-Dependent RNA Polymerase
... paramyxoviral polymerase with the inner leaflet of the cell membrane, and this may have implications for our understanding of the virus life ...the polymerase moves from these inclusions to the cell surface ...
9
Allosteric Effects of Ligands and Mutations on Poliovirus RNA-Dependent RNA Polymerase
... the polymerase opposite to that expected for a nucleic acid tem- plate (2, 4, ...3D polymerase, complexed with an RNA template-primer bound to the “front” of the polymer- ...3D polymerase on ...
9
RNA duplex unwinding activity of poliovirus RNA-dependent RNA polymerase 3Dpol.
... Belozersky Institute of Physical Chemical Biology, Moscow State University, Moscow 119899,2 and Institute of Poliomyelitis and Viral Encephalitides, Russian Academy of Medical Sciences, [r] ...
9
NusG Dependent RNA Polymerase Pausing and Tylosin Dependent Ribosome Stalling Are Required for Tylosin Resistance by Inducing 23S rRNA Methylation in Bacillus subtilis
... Regulation of B. subtilis tlrB expression combines tylosin-dependent ribosome stall- ing, transcription attenuation, and translation attenuation mechanisms. The mecha- nism regulating B. subtilis tlrB expression ...
14
De Novo Initiation of RNA Synthesis by the Arterivirus RNA-Dependent RNA Polymerase
... of RNA synthesis (8, 25). Ev- idence for primer-dependent activity of a CoV RdRp was presented in a study on the SARS-CoV nsp12/RdRp, which was found to be active in vitro on poly(A) templates with oligo(U) ...
12
Identification of poliovirus polypeptide P63 as a soluble RNA-dependent RNA polymerase.
... To determine whether both p63 and NCVP2 are required for polymerase activity, we further purified the soluble polymerase and analyzed the viral proteins associated with the purified enzy[r] ...
9
Genomic Characterization of Severe Acute Respiratory Syndrome-Related Coronavirus in European Bats and Classification of Coronaviruses Based on Partial RNA-Dependent RNA Polymerase Gene Sequences
... Bats may host emerging viruses, including coronaviruses (CoV). We conducted an evaluation of CoV in rhinolophid and vespertilionid bat species common in Europe. Rhinolophids carried severe acute respiratory syndrome ...
14
Initiation of minus-strand RNA synthesis by the brome mosaicvirus RNA-dependent RNA polymerase: use of oligoribonucleotide primers.
... minus-strand RNA 3 as the template for the synthesis of subgenomic RNA ...minus-strand RNA 3 to RdRp will lead to the synthesis of plus-strand subgenomic RNA ...subgenomic RNA 4 contain ...
5