Detoxifying enzymes
Anti-oxidative stress regulator NF-E2-related factor 2 mediates the adaptive induction of antioxidant and detoxifying enzymes by lipid peroxidation metabolite 4-hydroxynonenal
... toxifying enzymes such as AKR1C1 and GSTA4 in dif- ferent cell lines [18,19], although the molecular pathway is not fully ...these detoxifying genes is that they have ARE-like sequences in their 5’-flanking ...
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In vivo induction of phase II detoxifying enzymes, glutathione transferase and quinone reductase by citrus triterpenoids
... significantly induced GST activity against 4-nitroquinoline 1-oxide (4NQO), intestine (280%) and stomach (75%) while deacetyl nomilin showed significant induction only in intestine (73%). Induction of GST activity was ...
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Biochemical Characterization of Detoxifying Enzymes in Dimethoate Resistant Strains of Melon Aphid, Aphis gossypii(Hemiptera: Aphididae)
... The resistance patterns and biochemical basis underlying OP resistance, especially dimethoate, in Indian pop- ulations of A. gossypii is lacking and thus remains an issue for in-depth clarification. A better ...
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Bile acid detoxifying enzymes limit susceptibility to liver fibrosis in female SHRSP5/Dmcr rats fed with a high-fat-cholesterol diet
... chenodeoxycholate (CDCA) [19,22] contributed to HFC diet-induced liver damage and especially fibrosis [22]. The present histological and biological analyses indicated that HFC feeding also induces fibrotic ...
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Physalin A regulates the Nrf2 pathway through ERK and p38 for induction of detoxifying enzymes
... Nrf2 targets such as heme oxygenase-1 (HO-1), NAD(P)H quinone oxidoreductase (NQO-1), and GSTs encode phase II detoxification enzymes [15]. HO-1, a cytoprotective enzyme, regulates antioxidative and inflammatory ...
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A Detoxifying Oxygen Reductase in the Anaerobic Protozoan Entamoeba histolytica
... of detoxifying enzymes that act as oxygen and/or nitric oxide (NO) reductases (19, 30, ...protozoan enzymes have been shown to act as oxygen reductases (10, 25, ...
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Journal of Applied Pharmaceutical Science
... several detoxifying enzymes of oxidative stresses such as glutathione peroxidase and glutathione transferase and scavenges hydroxyl radicals and singlet oxygen species directly and detoxifying ...
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Effects of mutant TDP-43 on the Nrf2/ARE pathway and protein expression of MafK and JDP2 in NSC-34 cells.
... Nrf2 regulation of an antioxidant enzyme through interaction with ARE is considered an important endogenous antioxidant pathway (Buendia et al., 2016). Under normal conditions, Nrf2 in the cytoplasm is bound to its ...
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Piper betle induces phase I & II genes through Nrf2/ARE signaling pathway in mouse embryonic fibroblasts derived from wild type and Nrf2 knockout cells
... radical–detoxifying enzymes such as superoxide dismutase, catalase, and glutathione peroxidase during aging in erythrocyte of C57BL/6 mice [3] and increased the levels of nonenzymatic antioxidants such as ...
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Journal of Applied Pharmaceutical Science
... of detoxifying enzymes are present in the extrahepatic tissues such as lungs, kidneys and ...These enzymes include endogenous antioxidant enzymes such as catalase (CAT) and superoxide ...
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Development of the major arboviral vector Aedes aegypti in urban drain water and associated pyrethroid insecticide resistance is a potential global health challenge
... Keywords: Aedes aegypti, Arboviral diseases, Drain-water, Global health, Insecticide-detoxifying enzymes, Insecticide resistance, Mosquito vector biology Background Aedes aegypti mosqui[r] ...
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Hyperthermophilic Enzymes with Industrial Applications
... A number of thermophilic and hyperthermophilic proteases are now used in molecular biology and biochemistry procedures. Proteases can be used in DNA and RNA purification procedures. This enzyme can be used as an adjunct ...
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Phytochemicals in Vegetables and Health Protective Effects
... detoxification enzymes, allyl sulfides also inhibit phase I enzymes, such as cytochrome 450, which has been shown to activate chemical carcinogens, and promote ...
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Characterization of acetic acid-detoxifying Escherichia coli evolved under phosphate starvation conditions
... To determine whether the trkH80 muta- tion could change the activity of enzymes involved in glucose metabolism, we determined the levels of glu- cose and of acetic acid in spent media[r] ...
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Abnormal glucose homeostasis in skeletal muscle–specific PGC 1α knockout mice reveals skeletal muscle–pancreatic β cell crosstalk
... In accordance with previous results from studies of ROS-detoxifying gene expression in the brains of PGC-1α whole-body knockout animals 30, we found that expression of several of these d[r] ...
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ENZYMES
... optimum value, small changes in the charges of the enzyme and it’s substrate molecules will occur. This change in ionisation will affect the binding of[r] ...
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1.5 Enzymes
... • Spiders and flies secrete an enzyme soup into or on their food. In spiders, this is injected into the prey's body. The enzymes digest the prey's body contents and the spider sucks up the resulting digested food. ...
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EFFECT OF MALATHION TOXICITY ON DETOXIFYING ORGAN OF FRESH WATER FISH CHANNA PUNCTATUS
... organophosphorous insecticide widely used in agriculture and houses for the control of diseases vectors. It is a major source of environment poisoning in developing countries (WHO, 2003). Toxicological tests have shown ...
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Enzymes Boardworks
... Enzymes speed up reactions by lowering the activation energy (E a ) of a reaction.. The activation energy is the energy needed to start a reaction.[r] ...
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Influences of Genetic Abnormality on the Risk of Acute Lymphoblastic Leukemia
... carcinogen-metabolizing enzymes (CYP family, NQO1, GST), enzymes involved in folate metabolism (MTHFR, MTRR, SHMT, TS), and DNA repair enzymes (RAD51, XRCC1, ERCC2), chromosome translocation and ...
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