Deubiquitinating enzymes
The emerging role of deubiquitinating enzymes in genomic integrity, diseases, and therapeutics
... The addition of mono-ubiquitin or poly-ubiquitin chain to signaling proteins in response to DNA damage signal is thought to be a critical event that facilitates the recognition of DNA damage lesion site, the activation ...
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Simultaneous inhibition of deubiquitinating enzymes (DUBs) and autophagy synergistically kills breast cancer cells
... of deubiquitinating enzymes (DUBs), a critical component of UPS degradation, which are responsible for removal of ubiquitin monomers and chains prior to proteasomal ...
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Deubiquitinating enzymes related to autophagy : new therapeutic opportunities?
... Abstract: Autophagy is an evolutionary conserved catabolic process that allows for the degradation of intracellular components by lysosomes. This process can be triggered by nutrient deprivation, microbial infections or ...
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A method for assaying deubiquitinating enzymes
... Deubiquitinating enzymes (DUBs) are known to consist of a large protein family in eukaryotes. For example, the budding yeast has 17 genes for DUBs (4). Moreover, so far more than 60 full-length DUB ...
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Targeting deubiquitinating enzymes in cancer stem cells
... CSCs are difficult to eliminate by conventional treatment, mainly due to disorders of signal transduction and epi- genetics. The control of ubiquitination and deubiquitina- tion of CSC-related proteins determine the ...
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Deubiquitinating enzymes as oncotargets
... Gene expression is controlled by transcription factors that directly bind to DNA. Transcription factors act in complexes with other proteins and DUBs can affect their activity by deubiquitinating transcription ...
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Deubiquitination of type 2 iodothyronine deiodinase by von Hippel–Lindau protein–interacting deubiquitinating enzymes regulates thyroid hormone activation
... The present studies identify D2 as the only known specific substrate of VDU1 and VDU2, which in turn are the first ubiquitin-specific processing proteases (UBPs) known to specifically deubiquitinate an ERAD substrate. ...
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Ataxin-3 like (ATXN3L), a member of the Josephin family of deubiquitinating enzymes, promotes breast cancer proliferation by deubiquitinating Krüppel-like factor 5 (KLF5)
... To further confirm whether ATXN3L knockdown decreases KLF5 protein stability in human breast cancer cells, we knocked down ATXN3L in HCC1806 and SUM1315 two basal type triple negative br[r] ...
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The Epstein-Barr Virus (EBV) Deubiquitinating Enzyme BPLF1 Reduces EBV Ribonucleotide Reductase Activity
... (Ub)-activating enzymes; E2, Ub-conjugating proteins; and E3 enzymes, which are Ub ligases ...of deubiquitinating enzymes (DUBs) (43, ...
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The Papain-Like Protease of Severe Acute Respiratory Syndrome Coronavirus Has Deubiquitinating Activity
... have deubiquitinating activity on the basis of shared structural features with a cellular deubiq- uitinating enzyme, herpesvirus-associated ubiquitin-specific protease (HAUSP) (21, ...
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In Vivo Structure/Function Analysis of the Drosophila fat facets Deubiquitinating Enzyme Gene
... a deubiquitinating enzyme required for patterning the developing compound ...complex. Deubiquitinating enzymes are a large group of proteins that cleave ubiquitin-protein ...of ...
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Proteolytic Processing and Deubiquitinating Activity of Papain-Like Proteases of Human Coronavirus NL63
... Human coronavirus NL63 (HCoV-NL63), a common human respiratory pathogen, is associated with both upper and lower respiratory tract disease in children and adults. Currently, no antiviral drugs are available to treat CoV ...
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The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility
... Deubiquitinating enzymes are now emerging as potential therapeutic targets that control many cellular processes, but few have been demonstrated to control cell ...
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Deubiquitinating Enzyme Usp12 Is a Novel Co-activator of the Androgen Receptor
... Hence, deubiquitinating enzymes could offer novel therapeutic ...identify deubiquitinating enzymes that regulate AR; in that screen ubiquitin-specific protease 12 (Usp12) was identified as a ...
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The deubiquitinating enzyme UBPY is required for Lysosomal Biogenesis and productive autophagy in drosophila
... Autophagy is a catabolic process that delivers cytoplasmic components to the lysosomes. Protein modification by ubiquitination is involved in this pathway: it regulates the stability of autophagy regulators such as ...
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Deubiquitinating enzyme USP37 regulating oncogenic function of 14-3-3
... 14-3-3 is a family of highly conserved protein that is involved in a number of cellular processes. In this study, we identified that the high expression of 14-3- 3γ in various cancer cell lines correlates with the ...
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Deubiquitinating and Interferon Antagonism Activities of Coronavirus Papain-Like Proteases
... cellular deubiquitinating enzymes (57), and we and others demon- strated that PLpro is both a protease and a DUB (4, 39, ...and deubiquitinating activity, decreased but did not abrogate PLpro’s ...
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Profiling the orphan enzymes
... orphan enzymes at the superkingdom level was then estimated (Figure 6; the lists of local orphan and not observed EC numbers are available in Additional file 2: Tables ...orphan enzymes is higher in ...
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The Papain-Like Protease from the Severe Acute Respiratory Syndrome Coronavirus Is a Deubiquitinating Enzyme
... The identification of a coronavirus as the infectious agent of severe acute respiratory syndrome (SARS) and the rapid se- quencing of its genome have led to a renewed interest in coronaviruses (34). SARS, which emerged ...
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energy & enzymes ppt
... • Energy coupling uses the energy released from exergonic reactions to drive endergonic reactions, typically using the energy stored in ATP molecules... 5.12 ATP drives cellular work [r] ...
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