Developmental control by the Notch signalling pathway
A role of Sirt1 in the Notch signalling pathway
... doi:10.1016/0092-8674(91)90064-6 Rebeiz, M., Miller, S.W., Posakony, J.W., Adams, M.D., Celniker, S.E., Holt, R.A., Evans, C.A., Gocayne, J.D., Amanatides, P.G., Scherer, S.E., Li, P.W., Hoskins, R.A., Galle, R.F., ...
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Characterization of NOTCH signalling pathway in PTEN-deficient prostate tumorigenesis
... of Notch signalling were associated with upregulation of a p27- mediated cellular senescence response in both Pten pc-/- and Pten pc-/- ; Trp53 pc-/- ...known NOTCH target gene and it is a regulator ...
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Exploring the role of the Notch signalling pathway in normal and malignant human haematopoiesis
... with Notch signalling A collaboration with Professor Andrea Brancale at the School of Pharmacy of Cardiff University was setup, aiming to obtain candidate small molecule agonists of Notch ...
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"Notch Off": a perspective on the termination of Notch signalling
... regulate Notch signalling have been described, involving processes like transcriptional up-regulation of DSL ligands, their selective recy- cling to the cell membrane, and post-translational modifications ...
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An investigation into how the cell cycle and the Notch signalling pathway regulate pronephrogenesis in Xenopus laevis
... ICD mRNA (Fig 4.15F), therefore Cyclin A2 acts downstream of the Notch signalling pathway in primary neurogenesis, that is after specification of the primary neuron precursors. These results, ...
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The effects of inhibiting the notch signalling pathway in triple negative breast cancer cell lines
... effect Notch inhibition has on the F-actin ...activates Notch signal induced migration (Chen et ...that Notch inhibition of MDA-MB-231 cells by DAPT and R04929097 GSIs increases E-cadherin expression ...
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Cell autonomous integrin control of Wnt and Notch signalling during somitogenesis
... at signalling crossroads, and their interactions with other signal transduction pathways are key to the regulation of normal and pathological cell cytoarchitecture and ...a signalling cascade that acts ...
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Notch Signalling as a Therapeutic Target in Cancer
... cancer Notch plays a crucial role in mammary development and, as a result, abnormalities in the pathway lead to mammary ...between Notch and breast cancer came with the finding that the Notch4 locus ...
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Diverse requirements for Notch signalling in mammals
... the Notch signalling pathway in the process of somitogenesis, and the fact that the components of this system are very well characterised, these genes are a useful starting point to investigate the ...
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Nonlinear Dynamics of Notch -Delta Signalling
... The Notch signaling pathway is a highly conserved ell signaling system present in most multicellular ...different notch receptors, referred to as NOTCH1, NOTCH2, NOTCH3, and ...The Notch ...
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The role of Notch signalling in ovarian angiogenesis
... of Notch signalling pathway elements in the ovary and key roles for regulatory Notch signal- ling pathways on angiogenesis in pathological ...ovary. Notch signalling ...
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Notch activates Wnt 4 signalling to control medio lateral patterning of the pronephros
... Wnt-4 signalling to control medio-lateral patterning of the pronephros Richard ...the Notch signalling pathway during pronephrogenesis in the amphibian Xenopus laevis, and in nephron ...
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Notch signalling regulates left right asymmetry through ciliary length control
... molecular signalling pathways behind cilia formation are poorly ...that Notch signalling is a key pathway for cilia length ...when Notch signalling is ...charon. Notch ...
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Notch activates Wnt 4 signalling to control medio lateral patterning of the pronephros
... Wnt-4 signalling to control medio-lateral patterning of the pronephros Richard ...the Notch signalling pathway during pronephrogenesis in the amphibian Xenopus laevis, and in nephron ...
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Is there a role for Notch signalling in human breast cancer?
... unregulated Notch signalling has also been pro- posed in cervical cancer, largely because intense cyto- plasmic and nuclear staining of Notch1 and Notch2 proteins has been observed in a majority of early ...
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Identification of mutations in the PI3K-AKT-mTOR signalling pathway in patients with macrocephaly and developmental delay and/or autism
... In addition, we report here a second patient with bi- allelic germline PTEN mutations. Two PTEN mutations were identified in patient 3, where p.(Cys105Phe) was a de novo mutation and p.(Lys164Asn) was maternally ...
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Sequential combination of cisplatin with eugenol targets ovarian cancer stem cells through the Notch-Hes1 signalling pathway
... the Notch signal- ling [7]. The alteration of the Notch pathway genes has been reported in approximately 22% of all analyzed ovar- ian tumors ...The Notch path- way is primarily initiated by ...
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The Notch pathway in the developing hematopoietic system
... the control of both processes, including the vascular endothelial growth factor (VEGF) or the Angiopoietin/Tie receptor and, more recently, the Notch signaling ...
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New Capabilities of the Notch Signaling Pathway
... of Notch activation, while Dll4 induces more sustained ...to control relative levels of Hes1 and Hey1/L target gene expression. Notch activity in receiving cells is thus inherently multi-dimensional, ...
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Notch signalling mediates reproductive constraint in the worker honeybee
... of Notch signalling can overcome the repressive effect of queen pheromone and promote ovary activity in adult worker ...that Notch signalling acts on the earliest stages of oogenesis and that ...
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