Developmental defects
Lethal Developmental Defects: An Overview
... of developmental defects, in particular ...of developmental defects are of un- known origin [1] ...these defects besides genetic alterations. About 3% of all birth defects are ...
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Developmental Defects in a Caenorhabditis elegans Model for Type III Galactosemia
... involved in proteoglycan synthesis, N-glycosylation, O-glycosylation, and chitin and glycolipid synthesis have been isolated in this organism. Genetic and biochemical studies have demonstrated that most of the genes ...
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A comparison of photographic, replication and direct clinical examination methods for detecting developmental defects of enamel
... Photography has been used in some studies of tooth and enamel defects [3,4,9-14]. Assessing photographs is more objective than direct clinical examination. With photography it is possible for all cases (even from ...
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Pink1 Rescues Gal4 Induced Developmental Defects in the Drosophila Eye
... Parkinson disease pathology often includes the presence of ubiquitin-positive, α-synuclein-en- riched inclusions in the remaining neurons. Pink1 (also identified as PARK6) encodes a serine- threonine kinase involved in ...
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Diet, Disease, and Developmental Defects: Examining the Role of Environmental Stress in the Etiology of Skeletal Anomalies.
... evidence for this is derived from ethnohistorical accounts, which indicate that in addition to their role as the primary horticulturalists, Arikara women also participated in hunting activities (Wood, 1974). By ...
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Rapamycin ameliorates chitosan nanoparticle-induced developmental defects of preimplantation embryos in mice
... In our previous study, we showed that after morula stage embryos were developed to blastocyst in culture media with or without CSNPs, when they were transferred to recipients, the percentage of blastocysts resulting in ...
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Retinoic acid counteracts developmental defects in the substantia nigra caused by Pitx3 deficiency
... Because different lines of evidence suggest that Ahd2 is under the transcriptional control of Pitx3, we hypothesized that Ahd2, mediated through Pitx3, might have a role in the development of mdDA neurons. Ahd2 is a ...
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Developmental defects of enamel in primary teeth - findings of a regional German birth cohort study
... In the present study the dentist was able to identify DDE before post-eruptive enamel breakdown or the on- set of caries could occur owing to the prospective study design from birth to early childhood. By comparison, ...
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Developmental defects in pelagic fish embryos from the western Baltic
... T h e early developmental stages usually showed the highest malfor- mation rates (up to 5 1 % in the case of flounder embryos in stage la in 1984}; with progressive developmen[r] ...
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Valproic Acid Disrupts Hematopoiesis in Xenopus Laevis Through the Inhibition of Histone Deacetylase 3.
... To identify which HDAC is or are inhibited by VPA to prevent blood development, we utilized class I specific HDAC inhibitor compounds with overlapping specificities. Unfortunately, these compounds were not readily taken ...
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... The developmental defects of enamel are one of the most fre- quently observed developmental abnormalities of the human ...the defects of enamel matrix formation or mineralization or maturation ...
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Expanding the Indicator Bacteria Concept: A Novel Approach to Assess Ecosystem Risk in Impaired Waters
... Many studies report the relationship between coliform indicator bacteria levels and the overall quality of environmental water for public use. This study, an outgrowth of a long-term water- monitoring program within the ...
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Preconception paternal alcohol exposure exerts sex-specific effects on offspring growth and long-term metabolic programming
... broad developmental defects: distinctive craniofacial malformations, central nervous system defects and both prenatal and post- natal growth restriction [1, ...growth defects are characterized ...
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Di George Anomaly and Velocardiofacial Syndrome
... The Di George anomaly involves developmental defects of the third and fourth pharyngeal pouches, re- sulting in thymic and parathyroid hypoplasia and cardiac defects.. The cases of indiv[r] ...
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Identification of a Novel Point Mutation of Mouse Proto-Oncogene c-kit Through N-Ethyl-N-nitrosourea Mutagenesis
... T-to-C transition mutation that resulted in Phe-to-Ser substitution at amino acid 856 within a highly conserved tyrosine kinase domain. Compared with other c-kit mutants, Wads may present a novel loss- of-function or ...
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Inactivation of LAR family phosphatase genes Ptprs and Ptprf causes craniofacial malformations resembling Pierre Robin sequence
... The developmental defects observed in double-mutant embryos raised the question of where LAR family phosphatases act in the developing mandibular and maxillary ...
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Promiscuous and lineage-specific roles of cell cycle regulators in haematopoiesis
... CDK4 and -6 are the preferred catalytic subunits of cyclin D. Mice lacking the CDK4 gene display a dwarfism-like phenotype, infertility, and hypocellularity in many organs (see Table 1). However, no overt haematopoietic ...
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Chromosomal microarray analysis in developmental delay and intellectual disability with comorbid conditions
... heart defects and twenty other conditions (Table 1, also see Methods for ...heart defects (55%, ...heart defects and facial dysmorphism, the yield was also mark- edly elevated (38%, ...
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Phosphopantetheinyl Transferase CfwA/NpgA Is Required for Aspergillus nidulans Secondary Metabolism and Asexual Development
... sporulation defects of cfwA, ⌬ fluG, and ⌬ tmpA mutants were not rescued by the cfwA-dependent compounds identified ...lation defects of both ⌬ tmpA and ⌬ fluG single mutants, suggesting that unidentified ...
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Increased Risk for Developmental Disabilities in Children Who Have Major Birth Defects: A Population-Based Study
... birth defects, in the birth cohorts under study had been followed completely from age 1 year to 10 years to identify all cases of the selected ...analysis defects known to have poor survival ...birth ...
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