Diabetes and Endothelial dysfunction
Free radicals, diabetes and endothelial dysfunction
... in diabetes mellitus [3]. Diabetes mellitus in humans [4,5] and animal models of diabetes [6,7] are associated with impaired endothelium-dependent relaxation ...i.e. endothelial ...
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Epigenetic mechanisms of endothelial dysfunction in type 2 diabetes
... type-2 diabetes mellitus (T2DM) and its complications is largely due to the complex interaction between genetic factors and environmental influences, mainly dietary habits and lifestyle, which can either ...
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Oxidative stress, inflammation, endothelial dysfunction and incidence of type 2 diabetes
... adjustment for metabolic risk factors. An index of these two CAMs revealed an extended dose–response with a greater magnitude of association; whereas the other two CAMs measured (P-selectin and VCAM) were not asso- ...
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Inhibition of calpain reduces oxidative stress and attenuates endothelial dysfunction in diabetes
... Tg-CAST mice (data not shown). We then evaluated the vascular function by measuring endothelium-dependent relaxation. Our results showed that the response of aortic rings to Ach was almost abolished in eNOS-KO mice while ...
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CORRECTION OF ENDOTHELIAL DYSFUNCTION AMONG PATIENTS SUFFERING FROM DIABETES MELLITUS
... of endothelial dysfunction among patients with diabetes mellitus correcting the pro- and antioxidant system with the help of ...2 diabetes at the age of 40 to 60 ...of endothelial ...
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Effects of exenatide on postprandial vascular endothelial dysfunction in type 2 diabetes mellitus
... of diabetes mellitus, hypertension, and lipid metabolism during fasting ...vascular endothelial function is associated with postprandial hyperglycemia and hypertriglyceridemia ...vascular endothelial ...
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Quercetin Ameliorates Endothelial Dysfunction and Prevents Elevation of Asymmetrical Dimethylarginine in Experimental Diabetes
... on endothelial dysfunction and asymmetrical dimethylarginine (ADMA) levels in experimental diabetes, rats were divided into four groups including control, quercetin, diabetic and treated ...
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AMELIORATION OF ENDOTHELIAL DYSFUNCTION ASSOCIATED WITH DIABETES MELLITUS AND HYPERTENSION BY ETORICOXIB, LORNOXICAM AND ALLOPURINOL
... obtained. Diabetes and hypertension induced significant oxidative stress reflected by increase in lipid peroxidation level and decrease in antioxidant enzymes like catalase and superoxide ...
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Lack of Fibronectin Extra Domain A Alternative Splicing Exacerbates Endothelial Dysfunction in Diabetes
... Diabetes-associated vascular disease is characterized by endothelial dysfunction and by excess accumulation of basement membrane proteins in the subendothelial layer 1,2 . Fibronectin (FN), a ...
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Endothelial dysfunction: The contribution of diabetes mellitus to the risk factor burden in a high risk population
... of diabetes to the development of endothelial dysfunction in sub- jects with clustering of CVD risk factors may be early as indicated by significant functional changes pre- ceeding structural ...
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Endothelial dysfunction and antiplatelet therapy resistance assessment in patients with type 2 diabetes mellitus
... involving endothelial dysfunction, oxidative stress, chronic inflammation, platelet activation and the imbalance between coagulation and fibrinolysis promote atherogenesis and atherothrombotic complications ...
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Biomarkers of endothelial dysfunction in relation to impaired carbohydrate metabolism following pregnancy with gestational diabetes mellitus
... gestational diabetes mellitus (GDM) identifies a very young population of females predisposed for type 2 diabetes and cardiovascular ...disease. Endothelial dysfunction might represent a ...
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Endoplasmic Reticulum Stress: A Critical Molecular Driver of Endothelial Dysfunction and Cardiovascular Disturbances Associated with Diabetes.
... of endothelial cells and subsequent surface exposure of adhesion molecules, and release of cytokines, and chemokines, leading eventually to the enrollment of leukocytes, particularly ...chiefly endothelial ...
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Postprandial endothelial dysfunction in subjects with new-onset type 2 diabetes: an acarbose and nateglinide comparative study
... postprandial endothelial dysfunction are essential for the prevention of cardiovascular ...postprandial endothelial dysfunc- ...2 diabetes include α-glucosidase inhibitors and glinide ...
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Association of inflammation and endothelial dysfunction with metabolic syndrome, prediabetes and diabetes in adults from Inner Mongolia, China
... betes, diabetes or MetS or if development of the indi- vidual components of the MetS lead to inflammation and endothelial ...and diabetes were defined based on the fasting glucose along, which will ...
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Cellular and molecular mechanisms of endothelial dysfunction in diabetes.
... specifically on the EC. To date, in vitro studies of metabolic memory in cultured EC have largely focused on changes in gene expression in response to hyperglycaemia. 80 However, this review has highlighted the ...
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Endothelial dysfunction: Mechanisms and reversal in insulin resistance and diabetes mellitus
... 2.1 Overview Although not clinically emergent until later in life the pathophysiological processes which result in vascular disease evolve over a period of many years (Stary, 1989). Early atherosclerotic lesions are ...
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Protective effect of sitagliptin and rosuvastatin combination on vascular endothelial dysfunction in type-2 diabetes
... The effects were examined on body weight, serum glucose, triglyceride, cholesterol, blood pressure, heart rate, nitric oxide and antioxidant defensive enzymes. After completion of treatment schedule, the blood pressure ...
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HIV infected persons with type 2 diabetes show evidence of endothelial dysfunction and increased inflammation
... and endothelial dysfunction compared to either HIV infection by itself or T2D in uninfected ...of endothelial dysfunction would be found in per- sons with both HIV and T2D compared to persons ...
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Association between obstructive sleep apnea severity and endothelial dysfunction in patients with type 2 diabetes
... and endothelial function assessment in a relatively large sam- ple of ...peripheral endothelial function at the level of the arte- rioles, which are most importantly related to peripheral vascular ...
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