Diabetic Cardiomyopathy
Diabetic cardiomyopathy—What do we know about it?
... Diabetic cardiomyopathy is defined as the presence of myocardial dysfunction in patients with diabetes in the absence of coronary artery disease, hypertension, or other known cardiac ...
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Metabolic stress–induced activation of FoxO1 triggers diabetic cardiomyopathy in mice
... in diabetic patients is cardiovascular disease; diabetic cardiomyopathy is typified by alterations in cardiac morphology and function, independent of hypertension or coronary ...to ...
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Diabetic cardiomyopathy in Zucker diabetic fatty rats: the forgotten right ventricle
... since diabetic patients are prone to develop diabetic cardiomyopathy and myocar- dial ischaemia [4], it might be suggested that RV dysfunc- tion plays a central role in cardiac abnormalities in this ...
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Phenotyping diabetic cardiomyopathy in Europeans and South Asians
... on diabetic cardiomyopathy were performed in white populations or ethnicity was not reported ...the diabetic cardiomyopathy phenotype across ethnicities, whereas increased insight into the ...
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Dysregulation of the calcium handling protein, CCDC47, is associated with diabetic cardiomyopathy
... in diabetic cardiomyopathy (DCM) that is distinctly not attributed to co-morbidities with other vasculature dis- eases, which include coronary artery disease (CAD) or hypertension [1, ...
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Molecular mechanism of diabetic cardiomyopathy and modulation of microRNA function by synthetic oligonucleotides
... Diabetic cardiomyopathy (DCM) is a chronic complication in individuals with diabetes and is characterized by ventricular dilation and hypertrophy, diastolic dysfunction, decreased or preserved systolic ...
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Forkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathy
... expressions of peroxisome proliferator activated recep- tor (PPAR)α, myosin heavy chain (MHC)-β, and tumor necrosis factor (TNF)-α [79]. In addition, deficiency of muscle ring-finger protein (MuRF)2, an ubiquitin ligase ...
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Can the onset of heart failure be delayed by treating diabetic cardiomyopathy?
... DC: diabetic cardiomyopathy; DES: drug eluting stents; EASD: European Association for the Study of Diabetes; EF: left ventricle ejection fraction; FFA: free fatty acids; FFR: fractional flow reserve; HA: ...
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Effects of 1,25-dihydroxyvitamin D3 on pathological changes in rats with diabetic cardiomyopathy
... Background: The role of 1,25-dihydroxyvitamin D3 (vitamin D) in the apoptosis of diabetic cardiomyopathy (DCM) is unclear. This study is to investigate the effects of vitamin D on the pathological changes ...
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Original Article Promoter DNA demethylation of Keap1 gene in diabetic cardiomyopathy
... of diabetic and non-diabetic patients were ...in diabetic patients were found significantly decreased when compared to the non-diabetic ...in diabetic cardiomyopathy suggesting ...
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Diabetic cardiomyopathy: effects of fenofibrate and metformin in an experimental model – the Zucker diabetic rat
... specific cardiomyopathy called diabetic cardiomyopathy (DCM) ...in diabetic heart [10,19] but the rise in fatty acid uptake could be still more important resulting in accumulation of lipids ...
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Exercise as A Potential Therapeutic Target for Diabetic Cardiomyopathy: Insight into the Underlying Mechanisms
... Abstract: Diabetes mellitus is associated with cardiovascular, ophthalmic, and renal comorbidities. Among these, diabetic cardiomyopathy (DCM) causes the most severe symptoms and is considered to be a major ...
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Regulation of diabetic cardiomyopathy by caloric restriction is mediated by intracellular signaling pathways involving ‘SIRT1 and PGC-1α’
... 2]. Diabetic cardiomyopathy is mani- fested by increased cardiomyocyte stiffness and fibrotic ...in diabetic cardiomyopathy and during pressure overload results in diastolic dysfunction ...
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Targeting mitochondrial dynamics by regulating Mfn2 for therapeutic intervention in diabetic cardiomyopathy
... DCM: diabetic cardiomyopathy; DM: diabetes mellitus; Drp1: dynamic-related protein1; FCCP: carbonyl cyanide m-chlorophenylhydrazone; Fis1: mitochondrial fission 1 protein; FoxO1: forkhead box protein O1; ...
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DIABETIC CARDIOMYOPATHY: INSIGHTS INTO PATHOGENESIS, DIAGNOSTIC CHALLENGES, AND THERAPEUTIC OPTIONS
... Free Fatty Acid Metabolism Disturbances: Figure 2 summarizes the role of altered free fatty acid metabolism and its contribution to the development of diabetic cardiomyopathy. Figure 3 illustrates the role ...
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Original Article Carbamylated erythropoietin ameliorates cardiomyopathy via ERK (44/42) activation in rats with diabetic cardiomyopathy
... with diabetic-related heart disease include oxi- dative stress, inflammation, cardiac fibrosis, and myocardial ...in diabetic cardiomyopathy ...
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Predictors and prevention of diabetic cardiomyopathy
... Abstract: Despite our cognizance that diabetes can enhance the chances of heart failure, causes multiorgan failure,and contributes to morbidity and mortality, it is rapidly increasing menace worldwide. Less attention has ...
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Original Article Effect and mechanism of Huangqi gegen decoction (HGD) on diabetic cardiomyopathy of diabetic rats
... [1]. Diabetic cardiomyopa- thy (DCM) is a unique cardiovascular Disease, which is characterized with an increase in car- diac mass in response to applied ...stimulus. Diabetic patients are at an increased ...
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An Inhibition Effect on Diabetic Cardiomyopathy Fibrosis of db/db Mice through Reduction of Myocardial Protein N-glycosylation by Crude 1-DNJ Extract from Homemade Bombyx Batryticatus mori.L
... called diabetic cardiomyopathy (DCM) which is characterized as left ventricular contractile dysfunction [5], cardiomyocyte hypertrophy [6], interstitial collagen accumulation[7] and ...
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Diabetic Cardiomyopathy - Heart Disease in Diabetes
... with diabetic cardiomyopathy mainly use non-invasive techniques that show left ventricular hypertrophy and a reduction in both systolic and diastolic myocardial ...in diabetic patients without ...
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