Diabetic rat model
Original Article Control-released Alpha-lipoic acid-loaded PLGA microspheres enhance bone formation in type 2 diabetic rat model
... 2 diabetic rat model, and we demon- strated the feasibility of repairing critical-sized cranial bone defects with ALA-PLGA micro- spheres loaded 3D scaffolds made of collagen in rats with ...
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ANTI DIABETIC AND HYPOLIPIDEMIC ACTIVITY OF METHANOLIC EXTRACT OF ARISTOLOCHIA BRACTEOLATA ON STREPTOZOTOCIN INDUCED DIABETIC RAT MODEL
... anti- diabetic and hypolipidemic activity of methanolic extract of whole plant of Aristolochia bracteolata (MEAB) against streptozotocin (STZ) induced diabetic rat ...
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Assessment of autoantibodies to glutamate decarboxylase and anti-insulin in spontaneous diabetic dogs and experimental diabetic rat model
... this model to spontaneous diabetes in dogs is yet not well ...spontaneous diabetic dogs and well as experimentally induced diabetic rat ...
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Hyperbaric Oxygen Treatment in a Diabetic Rat Model Is Associated with a Decrease in Blood Glucose, Regression of Organ Damage and Improvement in Wound Healing
... investigated rat models of diabetes have beenWistar and Sprague Dawley rat strains induced by a single injection of streptozotocin (40 - 60 mg/kg) [12] ...modified diabetic rat model ...
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Valsartan reduces NOX4 expression and halts diabetic nephropathy in streptozotocin induced diabetic rat model
... Rats’ kidney tissues were dissected, rinsed in ice-cold PBS, and weighted. Left kidneys were fixed in 4% para- formaldehyde for histological studies. The right kidneys were excised into two parts: one part (30 mg) was ...
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EFFECT OF OBESTATIN ON CARDIOVASCULAR SYSTEM IN TYPE II DIABETIC RAT MODEL
... Type II diabetic patients have risk of cardiovascular disease mortality more than double compared with that in age-matched subjects. Also, Stroke events and all manifestations of coronary heart disease, myocardial ...
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Efficacy of biodegradable curcumin nanoparticles in delaying cataract in diabetic rat model
... Whatever the underlying mechanism, alterations in protein profile, and insolubilization of otherwise soluble protein, have been considered to be the ultimate changes that result in lens opacification. Therefore, we have ...
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Comparing Hypoglycemic Activity of Nopales (Opuntia Species) with Conventional Anti-Diabetic In Diabetic Rat Model
... Blood was obtained from rat tail tip. After restraining the rat, the tail was immersed in hot water (45 0 C). 1 mm of its tip was cut and a drop of blood which was collected was placed on glucometer strip ...
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Antidiabetic Activity of Spermadictyonsuaveolens in Streptozotocin Induced Diabetic Rat Model.
... Aim of the study was to study effects of repeated dose administration of extract of roots of Spermadictyonsuaveolens in streptozotocin induced diabetic rats.Effects of extract of Spermadictyonsuaveolens wasstudied ...
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<p>Safety of anti-VEGF treatments in a diabetic rat model and retinal cell culture</p>
... remained viable until double the clinical dose. The support cells around RGCs showed increased apoptosis at all doses. The observation correlates with the animal results since apoptotic death was also observed in the ...
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Effects of <em>Astragalus</em> polysaccharides on memory impairment in a diabetic rat model
... Results: After the 8-week APS treatment, serum fasting plasma glucose, hemoglobin A1c, and insulin levels were decreased compared with those of the model group (P,0.05). Importantly, memory impairment in the ...
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Mesenteric lymph nodes as alternative site for pancreatic islet transplantation in a diabetic rat model
... in diabetic rats; b) transplanted rats’ weight was increased after islet transplantation; c) transplanted rats’ social activities and health were improved after trans- plantation; d) living islets were ...
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<p>Lipid-Based Gliclazide Nanoparticles for Treatment of Diabetes: Formulation, Pharmacokinetics, Pharmacodynamics and Subacute Toxicity Study</p>
... Results: The factorial design experiment resulted in an optimum formulation coded 10F2 (150 mg PLX/10 min sonication). Scanning electron micrographs showed spherical parti- cles with smooth surface, whereas a ratio of ...
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MicroRNA profiling of diabetic atherosclerosis in a rat model
... Among the 15 genes targeted by the most DE-miRs (≥ 4) it may be possible to identify core DA-associated molecular targets. Metabolic and vascular factors can contribute to the generation and progression of DA. It has ...
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EVALUATION OF RAMIPRIL ON BLOOD SUGAR LEVEL AND INTERACTION WITH THE ORAL ANTI DIABETIC DRUGS IN ALLOXAN INDUCED DIABETIC RATS
... anti- diabetic drugs in alloxan induced diabetic ...in diabetic rats where it enhanced the hypoglycemic activity of all three Oral anti-diabetic drugs (Metformin, Gliclazide and ...
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Curcumin improves expression of SCF/c-kit through attenuating oxidative stress and NF-κB activation in gastric tissues of diabetic gastroparesis rats
... on diabetic gastroparesis, we examined its ef- fect on apoptosis in diabetic stomach sections by double ...from diabetic rats, we found an average of 80–100 apoptotic cells in a field of about 200 ...
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Biochemical and histological parameters in induced type 2 diabetic rats fed with high fat diet without exogenous cholesterol and low dose streptozotocin
... To treat T2DM patients several approaches have been used in the medical clinic such as adequate diet, physical exercises, and healthy lifestyle and in the more severe cases the use of hypoglycemic drugs. There are ...
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Phytochemical and pharmacological studies of L eptadenia pyrotechnica
... The Plant extracts also effectively prevented the atheromatic changes and plaque formation in the . Hepatic and aortic total cholesterol, lipid peroxidation and triglycerides were also lowered considerably in the rabbits ...
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Pharmacological evaluation of rat dorsal root ganglion neurons as an in vitro model for diabetic neuropathy
... Male Sprague-Dawley rats (Harlan Laboratories, Horst, The Netherlands) weighing 240–260 g were fed a standard rodent diet and had access to water ad libitum. Diabetes was induced by a single intraperitoneal injection of ...
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Original Article The effect of astragalus polysaccharide on the therapeutics of diabetic cardiomyopathy in diabetic rats and its mechanism
... in rat myocardial tissue that APS was able to reduce ROS expression, increase SOD and GSH-px activity, increase GSH content, restore the dynamic equilibrium between oxidative inju- ries and anti-oxidative injuries ...
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