(dihydro)ceramide synthase
Ceramide synthase 5 mediates lipid induced autophagy and hypertrophy in cardiomyocytes
... specific ceramide N-acyl chain length in this process and demon- strated a requirement for (dihydro)ceramide synthase 5 in cardiomyocyte autophagy and myristate-mediated ...
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Targeting ceramide synthase 6–dependent metastasis prone phenotype in lung cancer cells
... while ceramide synthase 2 (CERS2) and CERS6 expres- sion levels were found to be increased in cancerous breast tissues as compared with those in normal breast tissues ...on ceramide, as CERS6 ...
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Differential Regulation of Ceramide Synthase Components LAC1 and LAG1 in Saccharomyces cerevisiae
... that ceramide and its precursors have these potent signaling effects likely explains two related difficulties in the study of LAC1 and ...either ceramide synthase activity or large changes in the ...
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By activating Fas/ceramide synthase 6/p38 kinase in lipid rafts, Stichoposide D inhibits growth of leukemia xenografts
... Stichoposide D (STD) is a marine triterpene glycoside isolated from sea cucumbers. We examined the molecular mechanisms underlying the antitumor activity of STD in human leukemia cells. The role of Fas (CD95), ...
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TAP independent self peptides enhance T cell recognition of immune escaped tumors
... We previously isolated a CD8+ T cell clone LnB5 that specifically recognizes a TEIPP antigen from TRH4, a housekeeping ceramide synthase, presented by the MHC-I molecule Db on TAP-defici[r] ...
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Ceramide/Long-Chain Base Phosphate Rheostat in Saccharomyces cerevisiae: Regulation of Ceramide Synthesis by Elo3p and Cka2p
... between ceramide and ...both ceramide and LCBPs ...the ceramide synthase inhibitor australifungin (29), thus indicating that decreased consumption of LCBs for ceramide formation is ...
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Generation of specific deoxynojirimycin-type inhibitors of the non-lysosomal glucosylceramidase
... glucosylceramide synthase have been proposed in connection with this so-called substrate deprivation approach, including 1-phenyldecanoylamino-3-morpholino-1-propanol and its analogue ...
7
The therapeutic potential of modulating the ceramide/sphingomyelin pathway
... novo ceramide biosynthesis requires coordinate action of serine palmitoyl transferase and ceramide synthase to generate ...by ceramide synthase to generate ...to ceramide by ...
7
Daunorubicin activates NFkappaB and induces kappaB dependent gene expression in HL 60 promyelocytic and Jurkat T lymphoma cells
... by ceramide via enhanced ceramide synthase ...of ceramide has been directly linked with the activation of the transcription factor, NF k B, this was investigated as a novel target for the ...
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Obesity associated steatotic liver exhibits aberrant or altered sphingolipid composition and preferentially accumulates ceramide species containing long chain fatty acids
... LC-MS analysis of SPH revealed that there is a trend towards up-regulation of SPH in obese tissue, although the results for lean and obese rats do not differ signifi- cantly. Though SPH is a bioactive lipid that is ...
10
Ceramide activates NFkappaB by inducing the processing of p105
... Because ceramide has been shown to activate an as yet unidentified ceramide-activated protein kinase (16) as well as protein kinase C z (18), either may be ...
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Trans-, cis-, and dihydro-resveratrol: a comparative study
... of dihydro-R at picomolar and nanomolar concentra- tions are not limited to hormone-dependent breast can- cer cells but also present, albeit in a reduced scale, in androgen-independent prostate cancer ...and ...
6
Sphingolipid and ceramide homeostasis : potential therapeutic targets
... IPC synthase and inositol-based sphingolipids in mammalian cells, highlights the therapeutic potential of inhibitors tar- geting fungal IPC ...IPC synthase is a valid target for antiprotozoal compounds ...
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Anti ceramide antibody prevents the radiation gastrointestinal syndrome in mice
... radiation-induced ceramide locally reorganizes endothelial plasma membranes to form ceramide-rich platforms (CRPs), sites of ceramide-mediated trans- membrane signal transmission for diverse stresses ...
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Adiponectin/T-cadherin system enhances exosome biogenesis and decreases cellular ceramides by exosomal release
... ATP synthase subunit IF1 (A-21355, Thermo Fisher Scientific); rabbit polyclonal anti-AMPKα (2532, Cell Signaling Technology); and rabbit polyclonal anti–phospho-AMPKα (2531, Cell Signaling ...
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Expression of ceramide-metabolising enzymes in subcutaneous and intra-abdominal human adipose tissue
... and ceramide metabolism in adipose tissue and fat accu- mulation in the liver, we investigated associations be- tween gene expression in adipose tissue and liver in these non-obese ...
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Cytotoxic and inhibitory activity of ceramide on cancer cell lines
... as ceramide (n-acylsphingosine), sphingosine or rela- ted bases are important membrane components in animal ...form ceramide (Figure 1) and more complex sphingolipids are formed by the addition of polar ...
8
Anti Plasmodium activity of ceramide analogs
... non-natural ceramide analogs Non-natural analogs of ceramides were synthesized com- prising two functional groups [27] : 1) A phenyl group substituted on carbon 3 of a sphingoid-like backbone; with the phenyl ...
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The antiproliferative effect of C2-ceramide on lung cancer cells through apoptosis by inhibiting Akt and NFκB
... also reduces the pro-survival proteins Akt and NFκB, causing the down-regulation of survivin and cyclin A2, which are reported to frequently overexpress in non-small cell lung cancer [35]. This may sensitize lung cancer ...
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Human immunodeficiency virus type 1 infection of SK-N-MC cells: domains of gp120 involved in entry into a CD4-negative, galactosyl ceramide/3' sulfo-galactosyl ceramide-positive cell line.
... galactosyl ceramide (GalCer) or a derivative molecule, 3 * sulfo- galactosyl ceramide (GalS), may serve as an alternative receptor for HIV type 1 (HIV-1) in cells of neural and colonic ...
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