Dihydroartemisinin-Piperaquine
Randomized trials of artemisinin piperaquine, dihydroartemisinin piperaquine phosphate and artemether lumefantrine for the treatment of multi drug resistant falciparum malaria in Cambodia Thailand border area
... of dihydroartemisinin 40 mg and piperaquine phosphate 320 mg has been shown to be highly effective in treating falciparum malaria with an efficacy of over 90% in China, Vietnam, and Cambodia ...
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Choreoathetosis – an unusual adverse effect of dihydroartemisinin piperaquine: a case report
... of dihydroartemisinin- piperaquine in our ...limbs. Dihydroartemisinin-piperaquine-induced generalized choreoathetosis was ...and dihydroartemisinin-piperaquine was ...
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Intermittent screening and treatment with dihydroartemisinin piperaquine and intermittent preventive therapy with sulfadoxine pyrimethamine have similar effects on malaria antibody in pregnant Malawian women
... with dihydroartemisinin- piperaquine (Dp) and intermittent preventive therapy against malaria in pregnancy (Ipt) with sulfadoxine-pyrimethamine (SP) in Malawi, the impacts of IST-DP and IPT-SP on the ...
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Efficacy and safety of dihydroartemisinin piperaquine for treatment of Plasmodium falciparum uncomplicated malaria in adult patients on antiretroviral therapy in Malawi and Mozambique: an open label non randomized interventional trial
... received dihydroartemisinin–pipe- raquine (Eurartesim ® , Sigma Tau): 3 tablets for study participants < 60 kg or 4 tablets study for partici- pants ≥ 60 ...contained dihydroartemisinin/ ...
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Efficacy and safety of intermittent preventive treatment and intermittent screening and treatment versus single screening and treatment with dihydroartemisinin–piperaquine for the control of malaria in pregnancy in Indonesia: a cluster randomised, open label, superiority trial
... Pregnant women of any gravity attending their first antenatal visit were eligible if they had a viable pregnancy between 16 and 30 weeks’ gestation, were residents in the study catchment areas, were willing to complete ...
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Comparative study of the efficacy and tolerability of dihydroartemisinin piperaquine trimethoprim versus artemether lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Cameroon, Ivory Coast and Senegal
... of dihydroartemisinin - piperaquine phosphate - trimetho- prim (Artecom ® , Odypharm Ltd), which involves treat- ment over two days, appears to be a good alternative, particularly in malaria-endemic ...
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Intestinal permeability studies for piperaquine from dihydroartemisinin—piperaquine antimalarial product in the presence of lamivudine
... The study assessed the intestinal permeability of piperaquine (PQ) from dihydroartemisinin–piperaquine (DP) antimalarial in the presence of lamivudine (LMV). Excised tissues (duodenum and ileum) from ...
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Efficacy and safety of dihydroartemisinin piperaquine for treatment of Plasmodium falciparum uncomplicated malaria in adult patients on antiretroviral therapy in Malawi and Mozambique: an open label non randomized interventional trial
... Efficacy and safety of dihydroartemisinin-piperaquine for treatment of Plasmodium falciparum uncomplicated malaria in adult patients on antiretroviral therapy in Malawi and Mozambique:[r] ...
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Combination pharmacokinetics and pharmacodynamics of dihydroartemisinin piperaquine and primaquine in patients with uncomplicated falciparum malaria in halmahera Indonesia
... of dihydroartemisinin, piperaquine, and primaquine has been implemented in ...of dihydroartemisinin, piperaquine, and primaquine as well as its pharmacological ...
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The efficacy of dihydroartemisinin piperaquine and artemether lumefantrine with and without primaquine on Plasmodium vivax recurrence: A systematic review and individual patient data meta analysis
... Theta (variance of frailty parameter for clustering of study sites for the model of all regions) = 0.35. The assumption of proportional hazards did not hold for the model of all regions (p < 0.001 according to the ...
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High therapeutic efficacy of artemether–lumefantrine and dihydroartemisinin–piperaquine for the treatment of uncomplicated falciparum malaria in Somalia
... to piperaquine (PPQ) [7, 8] in South-East Asia are of great ...with dihydroartemisinin–piperaquine (DHA/PPQ) has been reported in Cambodia, Thailand and Viet Nam [7, 8, ...
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Prospective observational study to evaluate the clinical safety of the fixed dose artemisinin based combination Eurartesim® (dihydroartemisinin/piperaquine), in public health facilities in Burkina Faso, Mozambique, Ghana, and Tanzania
... Prospective observational study to evaluate the clinical safety of the fixed-dose artemisinin-based combination Eurartesim® dihydroartemisinin/ piperaquine, in public health facilities i[r] ...
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Efficacy of artemether–lumefantrine and dihydroartemisinin–piperaquine for the treatment of uncomplicated malaria in Papua New Guinea
... Background: In 2009, the Papua New Guinea (PNG) Department of Health adopted artemether–lumefantrine (AL) and dihydroartemisinin–piperaquine (DHA-PPQ) as the first- and second-line treatments for ...
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Pharmacokinetics of piperaquine and safety profile of dihydroartemisinin piperaquine co administered with antiretroviral therapy in malaria uninfected HIV positive Malawian adults
... Pharmacokinetics of piperaquine and safety profile of dihydroartemisinin piperaquine co administered with antiretroviral therapy in malaria uninfected HIV positive Malawian adults Pharmacokinetics of[.] ...
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User and Provider Acceptability of Intermittent Screening and Treatment and Intermittent Preventive Treatment with Dihydroartemisinin-Piperaquine to Prevent Malaria in Pregnancy in Western Kenya
... In the face of increasing Plasmodium falciparum resistance to SP [3] and reduced effective- ness of IPTp-SP in some settings [4, 5], the search for alternative drugs for IPTp and alternative prevention strategies to ...
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Dihydroartemisinin-piperaquine for treating uncomplicated Plasmodium falciparum malaria (Review)
... To combat the spread of resistance, the World Health Organiza- tion (WHO) now recommends that P. falciparum malaria is al- ways treated using a combination of two drugs that act at different biochemical sites within the ...
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Efficacy and safety of artemether lumefantrine and dihydroartemisinin piperaquine in the treatment of uncomplicated Plasmodium falciparum malaria in Kenyan children aged less than five years: results of an open label, randomized, single centre study
... The study comprised a three-day treatment period (day 1 taken as the first day of treatment) and 42-day follow-up. Eligible patients were randomized to one of the two treatment arms (1:1) to receive either AL dispersible ...
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Efficacy and safety of artemisinin naphthoquine versus dihydroartemisinin piperaquine in adult patients with uncomplicated malaria: a multi centre study in Indonesia
... of dihydroartemisinin and 320 mg of piperaquine) was administered three (body weight of ≤60 kg) to four tablets (body weight of > 60 kg) single daily dose for three days based on dosage of ...
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Malaria chemoprevention with monthly dihydroartemisinin piperaquine for the post discharge management of severe anaemia in children aged less than 5 years in Uganda and Kenya: study protocol for a multi centre, two arm, randomised, placebo controlled, superiority trial
... The main safety concern with DP is its dose-dependent QTc prolongation induced by the piperaquine component. Transient QTc prolongation has been confirmed in clinical trials but there are no data suggesting that ...
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Bioequivalence study of dihydroartemisinin-piperaquine (DHP) generic formulation in fixed-dose combination, in healthy Indonesian volunteers
... membrane. Dihydroartemisinin is a compound that is practically insoluble in water, but soluble in non-polar solvents, such as chloroform and ...Instead, piperaquine is practically insol- uble in non-polar ...
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