dimethylbenz[a]anthracene
![LUPEOL PROTECTS ABNORMALITIES IN CELL SURFACE MOITIES DURING 7, 12 DIMETHYLBENZ[A]ANTHRACENE INDUCED HAMSTER BUCCAL POUCH CARCINOGENESIS](data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==)
LUPEOL PROTECTS ABNORMALITIES IN CELL SURFACE MOITIES DURING 7, 12 DIMETHYLBENZ[A]ANTHRACENE INDUCED HAMSTER BUCCAL POUCH CARCINOGENESIS
... Lupeol, a pentacyclic triterpene, possesses diverse pharmacological and biochemical activities including anticancer and antioxidant effects. Abnormalities in the status of glycoconjugates and lipids in the cell results ...
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Preventive and curative effect of melatonin on mammary carcinogenesis induced by dimethylbenz[a]anthracene in the female Sprague–Dawley rat
... of dimethylbenz [a]anthracene-induced (DMBA-induced) mammary adenocarcinoma (ADK) has been previously well documented in the female Sprague–Dawley ...
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PROTECTIVE EFFECT OF THYMOQUINONE ON THE LIVER TISSUES OF 7, 12 DIMETHYLBENZ (A) ANTHRACENE INDUCED EXPERIMENTAL BREAST CANCER RATS
... Objective: Thymoquinone (TQ), the main active ingredient of the volatile oil isolated from the Nigella sativa seeds has been shown to possess a wide array of pharmacological effects. Recently, we have reported the ...
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PREVENTIVE EFFECTS OF PHOENIX DACTYLIFERA POLYPHENOLS AGAINST 7,12 DIMETHYLBENZ(A)ANTHRACENE INDUCED MAMMARY CANCER
... Vol 10, Issue 7, 2017 Online 2455 3891 Print 0974 2441 PREVENTIVE EFFECTS OF PHOENIX DACTYLIFERA POLYPHENOLS AGAINST 7,12 DIMETHYLBENZ(A)ANTHRACENE INDUCED MAMMARY CANCER RABAB OMRAN1*, ZAHRAA M AL TA[.] ...
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Obesity promotes 7,12 dimethylbenz(a)anthracene induced mammary tumor development in female zucker rats
... There has been only one study published that used female Zucker rats as a model to investigate the role of obesity in mammary tumor development [20]. That study used N-methyl- N-nitrosourea (MNU) as a carcinogen and ...
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Carcinogen 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis is accelerated in Smad3 heterozygous mice compared to Smad3 wild type mice
... Previous studies based on cell culture and xenograft animal models suggest that Smad3 has tumor suppressor function for breast cancer during early stages of tumorigenesis. In this report, we show that DMBA ...
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SINAPIC ACID ATTENUATES 7,12 DIMETHYLBENZ[A] ANTHRACENE INDUCED ORAL CARCINOGENESIS BY IMPROVING THE APOPTOTIC ASSOCIATED GENE EXPRESSION IN HAMSTERS
... 7,12-dimethylbenz[a] anthracene (DMBA)-induced experimental carcinogenesis in hamster have shown that [6] paradol facilitate the apoptosis as evidenced by the expression of p53 related gene expression ...
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EFFECT OF IRON OVERLOAD ON 7, 12-DIMETHYLBENZ (A) ANTHRACENE-INDUCED SKIN TUMORIGENESIS
... Iron dextran (imferon) was purchased from Rallis India, Ltd. Hair removing cream was from Anne French, Geoffrey Manners and Co. Ltd. (India). 7,12-dimethylbenz (a) anthracene (DMBA), and metal iron in ...
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Anti-cell Proliferative, Anti-inflammatory and Anti-angiogenic Potential of Lupeol in 7,12-dimethylbenz(a) Anthracene Induced Hamster Buccal Pouch Carcinogenesis
... Aim: Diverse pharmacological and biochemical effects of lupeol have been reported earlier. The present study utilized the immune expression pattern of proliferating cellular nuclear antigen (PCNA), cyclin D1, vascular ...
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Neonatal exposure of 17β-estradiol has no effects on mutagenicity of 7,12-dimethylbenz [a] anthracene in reproductive tissues of adult mice
... Previously, we evaluated 7,12-dimethylbenz [a] anthra- cene (DMBA)-induced mutagenicity in the heart, mam- mary gland, and uterine tissues as well as DMBA-induced carcinogenicity in the mammary and uterine ...
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PROTECTIVE EFFECT OF APIGENIN ON 7, 12 DIMETHYLBENZ (A) ANTHRACENE INDUCED GLYCOCONJUGATES IN THE PLASMA AND BUCCAL MUCOSA OF GOLDEN SYRIAN HAMSTERS
... Present study investigated the protective effect of apigenin on cell surface glycoconjugates abnormalities in 7, 12-dimethyldenz(a)anthracene(DMBA) induced hamster buccal pouch carcinogenesis. DMBA painting in the ...
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Vitamin D postpones the progression of epithelial ovarian cancer induced by 7, 12-dimethylbenz [a] anthracene both in vitro and in vivo
... We also found that vitamin D not only delayed malignant transformation of ovarian surface epithelial cells induced by DMBA but also played a chemo- preventive role in animal [r] ...
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Lack of ecotropic virus involvement in induction of lymphomas in DBA/2J mice by 7,12-dimethylbenz(a)anthracene.
... Since DBA/2J mice represent a unique system for the study of chemically induced B-cell lymphomas, it will be interesting to compare the nature of the activating lesions present in DMBA-i[r] ...
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Studies on the Chemopreventive Potential of N-acetyl cysteine/ zinc oxide nanocomposite combined with High ascorbate on 7,12-dimethylbenz(a)anthracene Induced Mammary Carcinogenesis in Rats
... In the present study the supplementation of N-acetyl cysteine /Zinc oxide Nanocomposite and high pH ascorbate after dosing of DMBA showed significant increase in SOD and CAT activit[r] ...
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Cissus quadrangularis inhibits tumor formation during 7, 12-dimethylbenz (a) anthracene induced oral carcinogenesis
... Though CqELet inhibited the formation of oral tumors in the buccal pouch of the DMBA treated hamsters, the observed precancerous lesions such as hyperkeratosis, hyperplasia a[r] ...
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P-MAPA immunotherapy potentiates the effect of cisplatin on serous ovarian carcinoma through targeting TLR4 signaling
... dimethylbenz(a)anthracene; ELISA: Enzyme-linked immunosorbent assay; FITC: Fluorescein Isothiocyanate; H&E: Hematoxylin and Eosin staining; HRP-conjugated: Horseradish peroxidase-conjugated; IFN: ...
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Anti-Tumor Potency and Toxicology of an Indian Ayurvedic Plant, Hygrophila Spinosa
... The chemical carcinogen, 7,12- Dimethylbenz[a]anthracene (DMBA) induced mammary gland tumor in rodent has been widely used as an animal model for development of chemopreventive drugs f[r] ...
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Modulation of growth and angiogenic potential of oral squamous carcinoma cells in vitro using salvianolic acid B
... Abbreviations DMBA: 7,12-dimethylbenz[a]anthracene; OSCC: oral squamous cell carcinoma; Sal B: Salvianolic acid B; MVD: microvessel density; HIF-1α: Hypoxia inducible factor 1, alpha sub[r] ...
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Chemopreventive Potential of Bauhinia variegata Flower Extract Against DMBA-induced Skin Papillomagenesis in Mice
... The present investigation was undertaken to explore the Chemopreventive action of Bauhinia variegata flower extract on 2-stage skin carcinogenesis, induced by a single topical application of 7, ...
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Cancer chemoprevention and therapy using chinese herbal medicine
... dimethylbenz(a)anthracene; EGCG: Epigallocatechin-3-gallate; EGFR: Epidermal growth factor receptor; ENNG: N-ethyl-N'-nitro-N- nitrosoguanidin; GSK-3ß: Glycogen synthase kinase-3ß; GTE: Green tea extract; ...
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