Dipeptidyl peptidase
In silico Structure Modeling and Docking Studies Using Dipeptidyl Peptidase 4 (DPP4) Inhibitors against Diabetes Type 2
... hypoglycemic, dipeptidyl peptidase (DPP4) inhibitors could block the dipeptidyl peptidase 4 (DPP4) ...of dipeptidyl peptidase 4 [Homo sapiens] ...
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Inhibition of dipeptidyl peptidase-4: The mechanisms of action and clinical use of vildagliptin for the management of type 2 diabetes
... The short half-life of GLP-1, due to its rapid degradation by the ubiquitous dipeptidyl peptidase-4 (DPP-4) enzyme, would require the hormone to be infused continuously to achieve therapeutic effect. This ...
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Inhibition of dipeptidyl peptidase IV by fexofenadine: Virtual screening study
... Kim D, Wang L, Beconi M, Eiermann GJ, Fisher MH, He H, Hickey GJ, Kowalchick JE, Leiting B, Lyons K, Marsilio F, McCann ME, Patel RA, Petrov A, Scapin G, Patel SB, Roy RS, Wu JK, Wyvratt MJ, Zhang BB, Zhu L, Thornberry ...
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Dipeptidyl Peptidase-IV Inhibitors: Pharmacological Profile and Clinical Use
... A decade and a half ago, the choice of an oral antihypergly- cemic agent for any particu- lar patient was in some ways a debate of nuance. Sulfonylureas (SUs) were the only class available, and provid- ers were left to ...
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Dipeptidyl peptidase-4 inhibitors in the management of type 2 diabetes: safety, tolerability, and efficacy
... The dipeptidyl peptidase-4 (DPP-4) inhibitors constitute a relatively new class of oral medications for the treatment of type 2 diabetes, which has become widely incorporated into clinical ...
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Dipeptidyl peptidase-4 inhibitor compared with sulfonylurea in combination with metformin: cardiovascular and renal outcomes in a propensity-matched cohort study
... Dipeptidyl peptidase-4 inhibitors (DPP4i) are com- monly used oral glucose-lowering agents that have intermediate efficacy with a low risk of hypoglyce- mia and neutral effects on body weight ...
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Dipeptidyl peptidase-4 inhibitors improve arterial stiffness, blood pressure, lipid profile and inflammation parameters in patients with type 2 diabetes mellitus
... of dipeptidyl peptidase-4 inhibitors (DPP-4i): sitagliptin and vildagliptin on augmentation index standardized for 75 beats per minute (cAiX@75), blood pressure (BP), lipid profile and high-sensitivity ...
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Treatment progression in sulfonylurea and dipeptidyl peptidase-4-inhibitor cohorts of type 2 diabetes patients on metformin
... This retrospective study compares adherence to, persistence with, and treatment progression in sulfonylurea (SU) and dipeptidyl peptidase-4 (DPP-4) inhibitor patient cohorts with T2D o[r] ...
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Are dipeptidyl peptidase-4 inhibitors effective and safe in long term when added to ongoing therapies of diabetics? a real-life study in tertiary referral center
... Methods: The study was conducted in diabetes mellitus outpatient clinic of Kayseri Training and Research Hospital between February 2012 and May 2017, with patients who did not achieve the sufficient success in diabetes ...
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Dipeptidyl peptidase IV reduces trophoblast invasion by inhibiting the activity of MMPs
... ABSTRACT Preeclampsia is a severe pregnancy complication in part due to insufficient implanta- tion. This study aimed at elucidating the mechanism of action of dipeptidyl peptidase IV (DPPIV) in ...
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EFFECTIVENESS OF DIPEPTIDYL PEPTIDASE – 4 INHIBITORS IN STREPTOZOTOCIN INDUCED NEURODEGENERATIVE MICE
... ABSTRACT: Introduction: Neurodegenerative diseases are incurable and debilitating condition that results in progressive degeneration and / or death of nerve cells. Anti-oxidants, Antihyper-glycemics and insulin ...
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Mast cell dipeptidyl peptidase I mediates survival from sepsis
... protease dipeptidyl peptidase I (DPPI) activates granule-associated serine proteases, several of which play important roles in host responses to bacterial ...
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Acute Respiratory Infection in Human Dipeptidyl Peptidase 4-Transgenic Mice Infected with Middle East Respiratory Syndrome Coronavirus
... M iddle East respiratory syndrome coronavirus (MERS-CoV) was originally isolated as a novel coronavirus from a fatal case of acute respiratory distress syndrome and renal failure in 2012 (1). A human receptor for the ...
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Dipeptidyl Peptidase 10, a Novel Prognostic Marker in Colorectal Cancer
... percentage of stained tumor cells. Staining intensity was classified as 1 for weak, 2 for moderate, or 3 for strong staining. H scores ranged from 0 to 300. Then, in order to determine a cutoff value of H score, ...
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Navigating the chemical space of dipeptidyl peptidase-4 inhibitors
... Abstract: This study represents the first large-scale study on the chemical space of inhibitors of dipeptidyl peptidase-4 (DPP4), which is a potential therapeutic protein target for the treatment of ...
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Distribution of Dipeptidyl Peptidase IV in Patients with Chronic Tonsillitis
... Interactions between T and B lymphocytes in the tonsils upon antigen stimulation depend on the expression of different costimulatory molecules, including proteolytic ectoenzymes. The data from several studies provide ...
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Dipeptidyl Peptidase IV (DPP-IV) Inhibitory Activity of Metformin
... Dipeptidyl peptidase IV is plasma membrane glycoprotein exopeptidase, inhibition of DPP-IV activity could be a useful strategy to enhance the activity of ...
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Regulation of dipeptidyl peptidase 4 production in adipocytes by glucose
... (F) Adipocytes obtained from high-fat diet-fed mice fed for 4 weeks were incubated in 5.5 (closed columns) or 25 mM glucose (open columns), and intracellular and released DPP4 levels we[r] ...
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Incretins and the intensivist: what are they and what does an intensivist need to know about them?
... and dipeptidyl-peptidase-4 inhibitors) have recently been incorporated into standard algorithms for the management of hyperglycaemia in ambulant patients with type 2 diabetes and, inevitably, an increasing ...
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Risk of diarrhea in patients with type 2 diabetes mellitus treated with sitagliptin: a meta-analysis of 30 randomized clinical trials
... Conclusion: Our study has shown that there is no difference in diarrhea risk between sitagliptin and controlled therapies. Moreover, sitagliptin is not a medicine that potentially increases the risk of diabetic diarrhea. ...
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