dipeptidyl peptidase-4 inhibitors
Overview of the Gliptin Class (Dipeptidyl Peptidase-4 Inhibitors) in Clinical Practice
... Introduction Dipeptidyl peptidase-4 inhibitors (DPP-4s), also commonly called gliptins, are a rela- tively new class of drugs for the treatment of type 2 ...
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DIPEPTIDYL PEPTIDASE - 4 INHIBITORS IN REGALING TYPE 2 DIABETES MELLITUS: A REVIEW
... Keywords: Diabetes mellitus, DPP-4, incretin, sitagliptin. INTRODUCTION Type 2 diabetes which is a non-in reverse ailment is hugely proliferating all through the world. Impairment of the pancreatic β-cells and ...
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Dipeptidyl Peptidase 4 Inhibitors and Inflammation: Dpp 4 Inhibitors Improve Mean Pleatelet Volume and Gamma Glutamyl Transferase Level
... DPP-4 inhibitors and it was ...of dipeptidyl peptidase-4 inhibitors was ...by dipeptidyl peptidase-4 inhibitors in ...
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Incretin System: Recent Advances in Glucagon Like Peptide-1 and Dipeptidyl Peptidase-4 Inhibitors
... Manmohan Memorial Medical College, Swoyambhu, Kathmandu, Nepal ABSTRACT The endogenous incretins, glucose-dependent insulinotropic polypeptide and Glucagon-like peptide, are peptide hormones secreted from endocrine cells ...
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Play of Chance Versus Concerns Regarding Dipeptidyl Peptidase-4 Inhibitors: Heart Failure and Diabetes
... Regarding Dipeptidyl Peptidase-4 Inhibitors: Heart Failure and Diabetes Vani ...of dipeptidyl peptidase-4 (DPP-4) inhibitors, with a closer look at a few ...
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Comparative Cardiovascular Risks of Dipeptidyl Peptidase-4 Inhibitors: Analyses of Real-world Data in Korea
... To the best of our knowledge, this study was the first to investigate the associations between DPP-4i and cardiovascular risk among people with type 2 diabetes using nationwide real- world data from Korea. Despite ...
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All-cause mortality of insulin plus dipeptidyl peptidase-4 inhibitors in persons with type 2 diabetes
... 4inhibitors: Dipeptidyl peptidase-4 inhibitors; GIP: Glucose-dependent insulinotropic peptide; GLP-1: Glucagon-like peptid-1; HbA 1C : Hemoglobin A1C; HF: Heart failure; HRs: Hazard ratios; ...
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Cost effectiveness analysis of metformin+dipeptidyl peptidase 4 inhibitors compared to metformin+sulfonylureas for treatment of type 2 diabetes
... Prior research compared short-term cost-effectiveness of two alternative drugs for treatment of T2D. To the best of authors’ knowledge, no previous US studies assessed the cost-effectiveness of alternative T2D treat- ...
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Sodium-glucose cotransporter 2 inhibitors combined with dipeptidyl peptidase-4 inhibitors in the management of type 2 diabetes: a review of current clinical evidence and rationale
... namely, dipeptidyl peptidase-4 inhibitors and sodium-glucose cotransporter 2 inhibitors, and considers the possible role of such dual therapy in the management of ...
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Effect of dipeptidyl-peptidase-4 inhibitors on C-reactive protein in patients with type 2 diabetes: a systematic review and meta-analysis
... Background: Dipeptidyl peptidase-4 inhibitors (DPP-4i) are emerging glucose-lowering agents through interacting with DPP-4 substrate, impact of which on systemic inflammation in type 2 ...
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Navigating the chemical space of dipeptidyl peptidase-4 inhibitors
... of inhibitors of dipeptidyl peptidase-4 (DPP4), which is a potential therapeutic protein target for the treatment of diabetes ...DPP4 inhibitors was also performed to unravel key ...
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EFFECTIVENESS OF DIPEPTIDYL PEPTIDASE – 4 INHIBITORS IN STREPTOZOTOCIN INDUCED NEURODEGENERATIVE MICE
... R. J. Vaidya * , N. H. Chauhan, B. A. Vyas and S. A. Shah Maliba Pharmacy College, Ukatarsadia University, Tarsadi - 394350, Gujarat, India. ABSTRACT: Introduction: Neurodegenerative diseases are incurable and ...
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Dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes: a comparative review
... The dipeptidyl peptidase (DPP)-4 inhibitors are a new class of antihyperglycaemic agents which were developed for the treatment of type 2 diabetes by rational drug design, based on an ...
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The Potential of some Plant Extracts as Radical Scavengers and Dipeptidyl Peptidase-4 Inhibitors
... vinifera seeds recorded the highest content of TF (75.9 ± 0.3 mg catechin equivalent/g dry mass). The C. robusta bean aqueous extract was remarkable in scoring the highest DPPH RSA (87.2 ± 1.2%), while O. europaea leaf ...
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DIPEPTIDYL PEPTIDASE 4 INHIBITORS: POTENTIAL FOR TREATMENT OF METABOLIC SYNDROME AND DEVELOPED FORMULATION APPROACHES
... DPP4 inhibitors have potential in the management of multifactorial diseases beyond glycemic control, the developed formulation approaches on DPP4 inhibitors are mainly in context with treatment of ...DPP4 ...
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Dipeptidyl peptidase-4 inhibitors in the management of type 2 diabetes: safety, tolerability, and efficacy
... DPP-4 inhibitors is the potential beneficial effect they exert on pancreatic beta ...DPP-4 inhibitors have demonstrated that exposure to these agents inhibits apoptosis, augments beta cell ...
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Dipeptidyl peptidase-4 inhibitors in type 2 diabetes therapy – focus on alogliptin
... These observations have been explained as being due to incomplete data and reporting bias in the FDA database. 70 In preclinical toxicology studies, GLP-1 activation pro- moted the development of C-cell hyperplasia and ...
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Dipeptidyl peptidase-4 inhibitors and GLP-1 reduce myocardial infarct size in a glucose-dependent manner
... observed at a glucose level of 11 mmol/L and not at 5 mmol/L. Interestingly, the glucose-dependency was also observed in GLP-1 mediated cardioprotection with infarct-limitation being observed at glucose levels of 7, 9, ...
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<p>Predictors of the Efficacy of Dipeptidyl Peptidase-4 Inhibitors in Taiwanese Patients with Type 2 Diabetes Mellitus</p>
... DPP-4 inhibitors pre- ferentially are its low risk of hypoglycemia, neutral effect on body weight change, rare occurrence of major side effects and recent evidence to improve long-term glyce- mic ...
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Sitagliptin, vildagliptin and saxagliptin dipeptidyl peptidase-4 inhibitors ( gliptins ) for add-on therapy in type 2 diabetes mellitus
... a dipeptidyl peptidase 4 (DPP-4) inhibitor (gliptin), a thiazolidinedione (glitazone) or a glucagon-like peptide-1 despite treatment with either metformin or a sulfonylurea, and when a ...
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