Direct-Acting Antiviral
Pharmacogenetics of hepatitis C: transition from interferon-based therapies to direct-acting antiviral agents
... another direct-acting antiviral agent plus ribavirin achieved an SVR12, ie, 9/9 (100%) of those receiving sofosbuvir, ledipasvir, and ribavirin and 10/10 (100%) of those receiv- ing sofosbuvir, ...
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Hepatic steatosis in HCV-infected persons in the direct-acting antiviral era
... (IFN)-free direct- acting antiviral regimens have been developed for HCV ...these direct-acting antiviral regimens are now the treatment of choice for all HCV ...
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<p>Direct-Acting Antiviral Drugs and Occurrence of Hepatocellular Carcinoma: Unjust or Oppressed</p>
... with direct-acting antivirals between March 2016 till March 2019 and the follow-up time after initiation of direct- acting antiviral treatment has been (12 – 30 ...
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Modeling HIV-HCV coinfection epidemiology in the direct-acting antiviral era: the road to elimination
... HCV direct-acting antiviral (DAA) agents are associ- ated with a sustained virological response (SVR) rate of over 90% regardless of the genotype, including in HIV- infected patients [7, ...
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Hepatitis C in healthcare personnel: secondary data analysis of therapies with direct-acting antiviral agents
... DAA: Direct-acting antiviral agent; DSV: Dasabuvir; ETR: End-of-treatment sustained virological response rate; GECCO: German Hepatitis Cohort; HBV: Viral hepatitis B; HCV: Viral hepatitis C; HIV: ...
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Adoption of direct acting antiviral medications for hepatitis C: a retrospective observational study
... Methods: This is a retrospective, secondary data analysis among a national cohort of patients prescribed direct-acting antiviral HCV medications with curative intent. We assessed prescriptions by ...
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A systematic review and meta analysis of community and primary care based hepatitis C testing and treatment services that employ direct acting antiviral drug treatments
... funded Direct Acting Antiviral (DAA) drug treatment may be due to provider concerns regard- ing co-morbidities, adherence, and side effects manage- ment ...
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Barriers to care for chronic hepatitis C in the direct acting antiviral era: a single centre experience
... ered lab ineligible for IFN therapy, subjects were required to have the abnormal lab value(s) for at least 3 months. Patients were also considered ineligible for IFN-based therapy if they had major uncontrolled ...
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Prevalence of hepatitis C virus-resistant association substitutions to direct-acting antiviral agents in treatment-naïve hepatitis C genotype 1b-infected patients in western China
... Next, to understand the covariance relationship among the different regions, a covariance-network analysis was undertaken. As shown in Figure 4A, there were a considerable number of amino-acid covariance positions ...
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A study of the circulating fibroblast growth factor 21 as a novel noninvasive biomarker of hepatic injury in genotype-4 chronic hepatitis C: Egyptian patients and their response to direct-acting antiviral agents
... study, the univariate analysis revealed a significant positive correlation of FGF21 with serum albumin (r= 0.3, P≤ 0.002), and the multiple linear regression analysis documented the mean serum albumin level as ...
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The role of a hepatitis C virus vaccine: modelling the benefits alongside direct-acting antiviral treatments
... In each scenario, a deterministic model of HCV transmission among PWID was used to predict 1 the additional prevalence reduction that could be achieved by vaccinating after treatment and[r] ...
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Price and affordability of direct-acting antiviral regimens for hepatitis C virus in the United States
... price paid to the pharmaceutical company is the initial payment it receives, minus the subsequent rebates. Pharmaceutical companies give rebates to PBMs, pharma- cies, and government organizations. Formulary payments are ...
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Direct acting antiviral agents in the therapy of hepatitis C virus related mixed cryoglobulinaemia: a single centre experience
... Sollima et al. [32] reported a clinical response at week 12 after treatment in two of seven HCV-positive pa- tients with cryoglobulinaemia who were given all-oral antiviral therapy, but one of them had relapsed ...
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Changes in tryptophan and phenylalanine in chronic HCV patients treated with direct acting antiviral (sofosbuvir)
... That result can be confirmed again by Loftis et al., results who reported that baseline serotonin level, in combination with other variables such as liver fibrosis degree, may be clinically useful for identifying ...
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Safety and efficacy of elbasvir/grazoprevir for the treatment of chronic hepatitis C: current evidence
... Abstract: Treatments for hepatitis C virus (HCV) have advanced greatly, becoming more efficacious with fewer adverse events, due to the availability of direct-acting antiviral agents, which target ...
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Severe Guillain Barré syndrome associated with chronic active hepatitis C and mixed cryoglobulinemia: a case report
... by antiviral therapy by direct-acting antiviral agent, patient showed progressive recovery and was transferred 3 months after his first admission to a rehabilitation ...
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EVALUATION OF THE EFFICACY AND SAFETY OF COMPLEX THERAPY OF ACUTE RESPIRATORY DISEASES OF ADENOVIRAL ETIOLOGY IN YOUNG PEOPLE
... of direct-acting antiviral agents (oseltamivir and umifenovir) and Kagocel, an interferon inducer that stimulates the patient's innate immunity, is more effective than monotherapy with a ...
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<p>Lower Rates Of Naturally Occurring Resistance-Associated Substitutions (RASs) In Hepatitis C Virus (HCV)-Infected Chronic Kidney Disease (CKD) Patients Than In HCV-Infected Patients With Only Liver Disease</p>
... Hepatitis C virus (HCV) is a global health problem and affects 185 million people worldwide. 1 HCV therapy has been revolutionized with the recent introduction of direct-acting antiviral agents ...
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Training in emerging advances in chronic hepatitis C infection in Pakistan: the Teach - Pak project
... Given the high prevalence of HCV, urgent and sustained action is required on a number of fronts in order to halt the spread and eradicate HCV infection in Pakistan. One of the most important steps in this regard is to ...
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<p>Eradication of Hepatitis C Virus (HCV) Improves Survival of Hepatocellular Carcinoma Patients with Active HCV Infection – A Real-World Cohort Study</p>
... 8 Direct-acting antiviral agents (DAAs) can further increase the sustained virological response (SVR) rate even to over 90% and have become the new standard for the treatment of ...treatment, ...
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