Discovery and identification
Genomics driven metabolomics novel strategies for the discovery and identification of secondary metabolites
... structural identification of five lower concentrated products ob- tained from comparative metabolite profiling of deletion strains from the di-mo- dular NRPS in Chapter 2 is ...the discovery and de novo ...
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Discovery and Identification of an Application for Inter-Application Communication on a Home Network Using UPnP
... Key words: Application ID, UUID, UPnP, inter-application communication. 1. Introduction The countless applications available in the app marketplaces like iOS App store, Google Play, Windows Phone store and BlackBerry ...
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Microarray Analysis in Drug Discovery and Biomarker Identification
... false discovery rate(FDR) is calculated for each individual gene to offer a suitable cutoff ...biomarker identification for microarray timecourse ...
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Lead discovery strategies for identification of Chlamydia pneumoniae inhibitors
... the identification of nonconventional antichlamydial agents, including target-based and ligand-based virtual screening, ethnopharmacological approach and pharmacophore-based design of antimicrobial ...
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Biomarkers in Drug Discovery and Development: From Target Identification to Drug Marketing
... target identification, drug response ...target discovery as well as decision-making during development, and are also being used clinically for disease diagnosis and ...
7
CURRENT TRENDS IN DRUG DISCOVERY: TARGET IDENTIFICATION TO CLINICAL DEVELOPMENT OF THE DRUG
... drug discovery 12 ...drug discovery in current trend to show how selective the compounds are for the chosen target, and it is more and more gaining popularity among industrial researchers 13 ...rapid ...
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Development Of Tools For Phosphosite-Specific Kinase Identification And Discovery Of Phosphatase Substrates
... peptide identification probabilities were set at ≤1% false discovery rate (FDR) as determined by a reversed database search and proteins required just 1 unique ...
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The Impact of Guided Discovery Learning on the Performance of Grade 11 Learners in Identification of Ions
... Median for each questionnaire item was found to range between 1 and 2 i.e. strongly agree and agree, respectively. This shows that most learners appreciated learning identification of ions using guided ...
5
The discovery and identification of a candidate proteomic biomarker of active tuberculosis
... Peaks with mass/charge of 2554.6, 4824.4, 5325.7, and 8606.8 were detected by SELDI-TOF MS in serum samples from patients with tuberculosis, control subjects with lung cancer, chronic ob[r] ...
11
Discovery and identification of potential biomarkers of pediatric Acute Lymphoblastic Leukemia
... Serum samples from ALL patients were used for the puri- fication of the two up-regulated candidate protein biomarkers (8137 and 8937 m/z), and serum samples from healthy controls were us[r] ...
12
Topic Identification and Discovery on Text and Speech
... topic discovery. We have evaluated performance in topic discovery by distributional similarity to gold-standard topics as a proxy for human-annotated judgments of topic quality, and briefly compared the ...
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Challenges of the information age: the impact of false discovery on pathway identification
... representing special cases, the slope of the curve is 2466 articles per input node. Discussion These results demonstrate that pathways related to can- cer can be readily generated using sets of genes selected randomly ...
6
The Application of FAST-NMR for the Identification of Novel Drug Discovery Targets
... identification of novel anti-infectious targets may aid in avoiding common mechanisms of resistance and extend the lifetime of new antibiotics [8,9]. An underlying challenge to capitalizing on genome sequencing ...
17
Evolutionary Adaptive Discovery of Phased Array Sensor Signal Identification
... Evolutionary Adaptive Discovery of Phased Array Sensor Signal Identification Timothy R. McJunkin and Milos Manic Abstract— Tomography, used to create images of the internal properties and features of an object, ...
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The use of knowledge discovery databases in the identification of patients with colorectal cancer
... neural networks could identify patients at risk of colorectal cancer and therefore.. warrant urgent further assessment.[r] ...
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Semantic Association Identification and Knowledge Discovery for National Security Applications
... Abstract. Public and private organizations have access to vast amount of internal, deep Web and open Web information. Transforming this heterogeneous and distributed information into actionable and insightful ...
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Discrete False-Discovery Rate Improves Identification of Differentially Abundant Microbes
... ABSTRACT Differential abundance testing is a critical task in microbiome studies that is complicated by the sparsity of data matrices. Here we adapt for microbiome studies a solution from the field of gene expression ...
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Pattern discovery and cancer gene identification in integrated cancer genomic data
... The rapidly increasing size of integrated genomic datasets cre- ates an unprecedented opportunity to study cancer biology and discover biomarkers and therapeutic targets in a novel way. In this paper, we presented a ...
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: A Model System for Anti-Cancer Drug Discovery and Therapeutic Target Identification
... target identification approaches require each drug of interest to be immobilized to a bead or another affinity- or fluorescent- or radioactive-“tag” so that the target protein can be “pulled ...initial ...
13
Therapeutic Target Identification, Validation and Drug Discovery for Traumatic Brain Injury
... In addition to neuronal biomarkers, astrocyte-derived Glial Fibrillary Acidic Protein (GFAP) has also been detected to be elevated for up to 90 days post injury in the blood of mTBI patients (Bogoslovsky et al. 2017). In ...
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