disseminated tumor cell
Optimization of Immunofluorescent Detection of Bone Marrow Disseminated Tumor Cells
... circulating tumor cells (CTCs) in the blood and disseminated tumor cells (DTCs) in the bone marrow (BM) has proven to be chal- ...rare cell detection, another widely used strategy is based on ...
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Tracing the origin of disseminated tumor cells in breast cancer using single cell sequencing
... The cell of origin that prompts the last complete select- ive sweep can be termed the most recent common an- cestor (MRCA), the one cell from which all cancer cells in a tumor sample ...the ...
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Approaches to isolation and molecular characterization of disseminated tumor cells
... Micrometastatic cells in the bone marrow, now usually referred to as “disseminated tumor cells (DTCs)”, can be detected in early stage cancer patients. It has been hypothesized that DTCs represent key ...
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Comparative evaluation of cell free tumor DNA in blood and disseminated tumor cells in bone marrow of patients with primary breast cancer
... carcinoma cell line MCF-7 (ATTC, Rockville, MD, USA) was treated under the same ...as tumor cell-positive if at least one CK-positive cell was detected as analyzed by ...
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Circulating and disseminated tumor cells from breast cancer patient derived xenograft bearing mice as a novel model to study metastasis
... heterogeneity that is commonly seen in patients or some host-specific factors that may influence tumor initiation and progression. However, this observation emphasizes that the future studies to understand the ...
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Detection of disseminated tumor cells in lymph nodes from patients with early stage non-small cell lung cancer
... isolated tumor cells and micrometastases in lymph nodes from 266 stage I NSCLC patients, and concluded that the presence of neither of these were significantly associated with ...
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NR2F1 stratifies dormant disseminated tumor cells in breast cancer patients
... of tumor cells in some pa- tients compared with cytospins prepared from fresh ...circulating tumor cells (CTCs) from high volumes of peripheral blood, for instance by a multitube CellSearch analysis ...
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The presence and prognostic impact of apoptotic and nonapoptotic disseminated tumor cells in the bone marrow of primary breast cancer patients after neoadjuvant chemotherapy
... In the past decade, NACT has become an increasingly important strategy to treat PBC patients. Many clinical trials on systemic breast cancer treatment are currently conducted in the neoadjuvant situation, by using re- ...
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Prevention of cancer dormancy by Fbxw7 ablation eradicates disseminated tumor cells
... From a biological point of view, the upstream regulator of Fbxw7 expression in DTCs remains to be identified. Expression of p53 was previously shown to be increased in quiescent cells (50), and the Fbxw7 gene is a target ...
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Remodeling the Microenvironment before Occurrence and Metastasis of Cancer
... TNF-α: Tumor necrosis factor-alpha; PI3K: Phosphatidylinositol 3 kinase; Akt: Protein kinase B; mTOR: Mammalian target of rapamycin; MAPK: Mitogen-activated protein kinase; JAK: Janus kinase; STAT: Signal ...
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Engineered In Vitro Models of Tumor Dormancy and Reactivation
... with cell escape from the primary tumor and resulting in second- ary tumors in foreign tissue is termed the ‘metastatic ...primary tumor can in- vade the surrounding tissue, intravasate into nearby ...
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Enhanced detection and comprehensive in situ phenotypic characterization of circulating and disseminated heteroploid epithelial and glioma tumor cells
... larger tumor cells [5, 28, ...circulating tumor microemboli (CTM) and disseminated tumor cells (DTCs) derived from diverse types of solid tumor including lung, glioma, melanoma, ...
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Future medical applications of single-cell sequencing in cancer
... and disseminated tumor cells (DTCs) (Figure ...primary tumor, while DTCs are cells that disseminate into tissues such the ...epithelial cell adhesion molecule (EpCAM)) that allow them to be ...
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Evaluation of proliferation and apoptosis markers in circulating tumor cells of women with early breast cancer who are candidates for tumor dormancy
... that disseminated from the primary tumor and underwent a period of disease inactivity, termed dormancy, followed by a second period of active ...These disseminated tumor cells can per- sist ...
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Does primary neoadjuvant systemic therapy eradicate minimal residual disease? Analysis of disseminated and circulating tumor cells before and after therapy
... However, although a pathological complete response (pCR) can be achieved in a range of 7.7–36.4 % of cases (depending on intrinsic subtypes), showing improved long-term survival, about 20 % of all patients with BC will ...
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An intersellar collision tumor ganglion cell tumor with pituitary adenoma
... The recent reasonable speculations confirmed the common origin of neuronal and adenomatous elements. The stem/progenitor cells possess the ability of multidirectional differentiation and are the most likely cells of ...
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What's new on circulating tumor cells? A meeting report
... Since CSCs survive standard cancer therapies and can theoretically regenerate the tumor even after killing the bulk of tumor cells, novel treatment strategies should eliminate CSCs in order to be eff ective. ...
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Sepsis and septic shock: endothelial molecular pathogenesis associated with vascular microthrombotic disease
... “DIC” is still the result of hemostasis even though TF is not involved [4, 20]. The exocytosis of ULVWF from Weibel-Palade bodies activates ULVWF path and plate- lets are easily recruited because ULVWF show extremely ...
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Depleting tumor specific Tregs at a single site eradicates disseminated tumors
... s.c. tumor had a significant effect on the growth of the distant tumors (Figure 7E) but had little effect on the number of lung metastases (Figure ...4T1 tumor, we added a second course of ...4T1 ...
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The viable circulating tumor cells with cancer stem cells feature, where is the way out?
... permanent cell line isolated from the blood of a colon cancer patient, these CTCs had been cultured for more than 1 year ...cancer cell lines named LNCaP and PC3 as research ...different tumor ...
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