Disseminated Tumor Cells
Tracing the origin of disseminated tumor cells in breast cancer using single cell sequencing
... the cells that carry them and sparking clonal ...originating cells are inherited in all cancer ...cancer cells in a tumor sample ...the tumor [4, ...Cancer cells may intravasate ...
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Prognostic value of circulating tumor cells and disseminated tumor cells in patients with ovarian cancer: a systematic review and meta-analysis
... of disseminated tumor cells (DTCs) in bone marrow of patients with ovarian cancer have been reported [5, ...circulating tumor cells (CTCs) in peripheral blood. CTCs are tumor ...
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Optimization of Immunofluorescent Detection of Bone Marrow Disseminated Tumor Cells
... cer cells by liquid ...circulating tumor cells (CTCs) in the blood and disseminated tumor cells (DTCs) in the bone marrow (BM) has proven to be chal- ...rare cells (1 CTC ...
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A simple selection-free method for detecting disseminated tumor cells (DTCs) in murine bone marrow
... circulating tumor cells (CTCs) from the blood extravasating and invading the bone marrow – these cells within the bone marrow are referred to as disseminated tumor cells (DTCs) ...
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Review Article Prognostic value of circulating and disseminated tumor cells in ovarian cancer: a meta-analysis
... circulating tumor cells (CTCs) in peripheral blood and disseminated tumor cells (DTCs) in bone marrow have been investigated in many tumors; however, they remain a source of contro- ...
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Approaches to isolation and molecular characterization of disseminated tumor cells
... Micrometastatic cells in the bone marrow, now usually referred to as “disseminated tumor cells (DTCs)”, can be detected in early stage cancer ...these cells in breast and other cancers, ...
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Presence of apoptotic and nonapoptotic disseminated tumor cells reflects the response to neoadjuvant systemic therapy in breast cancer
... (lifelong) tumor cell ...dormant cells that will cause a meta- static ...stem cells since they are dormant but have the ability to regrow following treatment ...of tumor cell growth and meta- ...
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Prognostic relevance of disseminated tumor cells in the bone marrow and biological factors of 265 primary breast carcinomas
... Finally, one of the most prominent biological factors of breast carcinomas is the human epithelial growth factor receptor 2 (HER2 or cerbB2), which belongs to a family of four charac- terized subtypes of growth factor ...
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NR2F1 stratifies dormant disseminated tumor cells in breast cancer patients
... BM cells harbor up to five small ...line cells, and in test patient samples harboring many DTCs, a range from zero up to many, often large, irregular NR2F1 nuclear localization signals were observed, often ...
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Comparative evaluation of cell free tumor DNA in blood and disseminated tumor cells in bone marrow of patients with primary breast cancer
... circulating tumor cells (CTC) seems to be short (1 to 24 hours) and apoptotic cells signifi- cantly contribute to the circulating tumor cell fraction in breast cancer patients ...geneous ...
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Prevention of cancer dormancy by Fbxw7 ablation eradicates disseminated tumor cells
... metastatic cells often remain dormant for periods of years or even decades ...on tumor cells the ability to resist conventional therapies that target rapidly cycling cells and to eventually ...
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Persistence of disseminated tumor cells after neoadjuvant treatment for locally advanced breast cancer predicts poor survival
... of tumor cells both in bone marrow and peripheral blood, as this was the available and most standardized method at the time of the study ...breast tumor subtype ...
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Detection of disseminated tumor cells in lymph nodes from patients with early stage non-small cell lung cancer
... of tumor cells measuring be- tween ...isolated tumor cells as single tumor cells or small clusters of cells smaller than ...[4]. Tumor cells that have spread ...
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Circulating and disseminated tumor cells from breast cancer patient derived xenograft bearing mice as a novel model to study metastasis
... heterogeneity that is commonly seen in patients or some host-specific factors that may influence tumor initiation and progression. However, this observation emphasizes that the future studies to understand the ...
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Micrometastatic spread in breast cancer: detection, molecular characterization and clinical relevance
... single disseminated tumor cells (DTCs) in the bone marrow (BM) or the peripheral blood in 10% to 60% of breast cancer patients without signs of ...circulating tumor cell (CTC) levels may serve ...
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Dormancy in breast cancer
... Abstract: Tumor dormancy describes a prolonged quiescent state in which tumor cells are present, but disease progression is not yet clinically ...how tumor cells circulating in the ...
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Engineered In Vitro Models of Tumor Dormancy and Reactivation
... primary tumor and resulting in second- ary tumors in foreign tissue is termed the ‘metastatic ...cascade’. Cells originating from a primary tumor can in- vade the surrounding tissue, intravasate into ...
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Genomic alterations indicate tumor origin and varied metastatic potential of disseminated cells from prostate-cancer patients
... a tumor is presumably contained within cells that are able to escape and disseminate from the primary ...positive cells (i.e., cells of epithelial origin) in the peripheral circulation and ...
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Does primary neoadjuvant systemic therapy eradicate minimal residual disease? Analysis of disseminated and circulating tumor cells before and after therapy
... circulating tumor cells (CTCs), and to bone marrow (BM), reflected by disseminated tumor cells (DTCs) in up to 40 % of the patients [6, ...these cells have rarely been ...
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Enhanced detection and comprehensive in situ phenotypic characterization of circulating and disseminated heteroploid epithelial and glioma tumor cells
... cancer cells SW480 enriched from blood. Blue color of the tumor cells with pink nuclei clearly distinguish them from the brown color of ...circulating tumor stem cell (CTSC) and a CTC enriched ...
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