DKK-1
Serum level of DKK-1 and its prognostic potential in non–small cell lung cancer
... whether DKK-1 was secreted into the serum of patients with ...serum DKK-1 were sig- nificantly increased in patients with NSCLC compared with healthy ...serum DKK-1 level ...
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Original Article Expression and clinical significance of Dickkofp-1 (DKK-1) in neuroblastoma
... 11]. DKK-1 is also highly expressed in human hepatocellular carcinoma, intrahepatic cholangiocarcinoma, esophageal carcinoma and prostate cancers ...that DKK-1 can enhance tumor cell migration ...
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B cell depletion therapy upregulates Dkk 1 skin expression in patients with systemic sclerosis: association with enhanced resolution of skin fibrosis
... scleroderma. Dkk-1 is virtually undetectable in the skin of patients with SSc in sharp contrast to healthy skin where it is clearly ...downregulates Dkk-1 expression ...of Dkk-1 ...
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In Silico Structural Prediction and Production of a Chimeric Recombinant Dickkopf-1 (DKK-1) Antigen
... recombinant DKK-1, mice (n=15) were divided into two groups (test and ...rDKK- 1 was emulsified in Freund’s complete adjuvant (Sigma, USA) and boosters injections were performed four times by a ...
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Dickkopf 1 (Dkk 1) in plasma and synovial fluid is inversely correlated with radiographic severity of knee osteoarthritis patients
... of Dkk-1 in plasma and synovial fluid was performed by sandwich enzyme-linked immunosorbent assay (ELISA) using a commercially available test kit according to the manufacturer’s protocol (Quantikine, ...
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Original Article Serum HE4, MASP-2, and DKK-1 levels in patients with colorectal cancer
... cantly lower than they are in the normal population, lev- els which gradually change with the treatment process. This suggests that HE4, MASP-2, and DKK-1 may be involved with the occur- rence and ...
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miR-29a promotes osteoblast proliferation by downregulating DKK-1 expression and activating Wnt/β-catenin signaling pathway
... and DKK-1 played an important role in osteoblast dif- ...while DKK-1 inhibited the proliferation of ...while DKK-1 promoted the apoptosis of ...while DKK-1 ...
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Original Article Vorinostat (SAHA) promotes osteoblast differentiation and bone formation via Dkk-1 suppression
... Abstract: Objective: This study aims to elucidate the therapeutic effect of Vorinostat (SAHA), one of the histone deacetylase inhibitor (HDIs), against osteoporosis in vitro and in vivo, and its mechanism in Wnt signal ...
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Analysis of the expression profile of Dickkopf-1 gene in human glioma and the association with tumor malignancy
... the DKK-1 gene in 12 glioblastoma cell lines, medulloblas- toma cells, low-grade glioma cells, and human astrocytes as a control using semi-quantitative RT-PCR analysis (Figure ...SF295, DKK-1 ...
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Elevated levels of Dickkopf related protein 3 in seminal plasma of prostate cancer patients
... untagged Dkk-3 purified via HPLC (anion exchange followed by size exclusion chromatography) from conditioned media of stably transfected LNCaP cells [13] was used as stan- ...for Dkk-1 and ...
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High level of interleukin 32 gamma in the joint of ankylosing spondylitis is associated with osteoblast differentiation
... hibitor DKK-1 leads to the new bone formation in per- ipheral joints ...Interestingly, DKK-1 inhibition also leads to a bilateral erosive change and ankylosis of the sacroiliac joints in TNF ...
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Original Article Dickkopf-1 induces pancreatic carcinogenesis through upregulation of c-Myc and cyclin D1
... 27]. DKK-1 inhibits canonical Wnt signaling to promote tumor progression [6, ...that DKK-1 knockdown reduc- ed pancreatic cancer cell proliferation and migration by reducing c-Myc and cyclin ...
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Do hypoxia and L-mimosine modulate sclerostin and dickkopf-1 production in human dental pulp-derived cells? Insights from monolayer, spheroid and tooth slice cultures
... and DKK-1 in the dental pulp and its relevance in pulp healing is ...and DKK-1 in hard tissue formation and associated diseases, and their relevance in regenerative approaches, it is highly ...
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Elevated expression of Dickkopf-1 increases the sensitivity of human glioma cell line SHG44 to BCNU
... rate. DKK-1, however, is also reported to be overexpressed in tissues and serum of lung cancers and esophageal squamous cell carcinoma, suggesting that DKK-1 may act as pro-oncogene ...of ...
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-dependent VDR signaling delays ron-mediated breast tumorigenesis through suppression of β-catenin activity
... Total RNA was isolated from whole mammary glands, R7 cells, or human T47D cells using Tri-Reagent RT (Molecular Research Center, Inc., Cincinnati, OH) and subsequently reverse transcribed into cDNA (1.5 µg) using the ...
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Correlation of blood bone turnover biomarkers and Wnt signaling antagonists with AS, DISH, OPLL, and OYL
... identified DKK-1 as a bone mineral density (BMD)-associated gene in postmenopausal women, and serum DKK-1 levels are inversely associated with BMD in osteoporosis [23, ...26]. ...
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Type 2 diabetes affects bone cells precursors and bone turnover
... Methods: We enrolled in the study 21 T2DM women and 21 non diabetic controls matched for age and body mass index (BMI). In each subject we measured bone cell precursors, Receptor Activator of Nuclear Factor κ B (RANKL), ...
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Dickkopf 1 is regulated by the mevalonate pathway in breast cancer
... of DKK-1 in this report. Lower- ing DKK-1 levels may have direct practical implications for patients with osteotropic tumors because osteoblast activity may be normalized directly and ...
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Nuclear DICKKOPF-1 as a biomarker of chemoresistance and poor clinical outcome in colorectal cancer
... Statistical analyses were conducted using SPSS v13.0 (SPSS Inc, Chicago, IL). All reported P values are two-sided. Prognostic and predictive effects were assessed using as clinical endpoints progression-free survival ...
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Serum Dickkopf-1 expression level positively correlates with a poor prognosis in breast cancer
... [22,23]. DKK-4 was found to show high specificity for gastric cancer [24]. DKK-1, which was involved in some aspects of embryonic development, was detected in mature human tissues, mainly in the ...
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