DNA base excision repair
Studies on protein:protein interactions in mammalian DNA base-excision repair
... and DNA-binding protein, Calreticulin (CRT), and SLE patients also produce autoantibodies against CRT (reviewed in (Johnson et a l, ...the DNA-binding domain of glucocorticoid receptor (Holaska et a l, ...
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8 Oxoguanine causes neurodegeneration during MUTYH mediated DNA base excision repair
... Antibodies. The primary antibodies used were mouse monoclonal anti- 8-oxo–dG (N45.1, JaICa, Fukuroi); rabbit anti-DARPP32 (Cell Signaling Technology); mouse anti-DARPP32 (BD Transduction Laboratories); rat anti-F4/80 ...
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The alterations of XRCC1 gene’s polymorphism with a different SNP is involved in breast cancer
... 14. Luo H, Li Z, Qing Y, Zhang S-H, Peng Y, Li Q, et al. Single nucleotide polymorphisms of DNA base-excision repair genes (APE1, OGG1 and XRCC1) associated with breast cancer risk in a ...
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Sensitivity of markers of DNA stability and DNA repair activity to folate supplementation in healthy volunteers
... on DNA base excision repair capacity. DNA repair is crucial in maintaining genomic stability and compromised DNA repair is associated with increased risk of ...
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Base flipping in nucleotide excision repair
... two DNA substrates, we repeated the time-dependent fluo- rescence measurements with the same amount of ATP (1 m M ) and 20 m M CP and added extra ATP, ATP␥S, or ADP (3 m M ) at different time points after the ...
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Base excision repair and the role of MUTYH
... Recent findings from experiments employing full-length structure of MutY cross-linked to DNA containing 8-oxoG have shed light on the mechanism of recognition and removal of 8-oxoG:A mismatched by MutY. Although ...
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DNA-PK Deficiency in Alzheimer's Disease
... of DNA repair systems such as base excision repair (BER), nucleotide excision repair (NER), single strand break repair (SSBR), and double strand break repair ...
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Base excision repair of ionizing radiation-induced DNA damage in G1 and G2 cell cycle phases
... enhanced repair activities when cells were delayed in G2 ...higher repair endonuclease activity to incise 8-oxo-G than unirradiated cells ...enhanced repair activity might be a feature of ...
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The function of CUX1 in oxidative DNA damage repair is needed to prevent premature senescence of mouse embryo fibroblasts
... in base excision repair by stimulating the function of OGG1 has important implications beyond the repair of 8-oxoG ...of DNA glycosylases could be facilitated by DNA binding ...
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Genome stability pathways in head and neck cancers
... are DNA repair proteins that have direct affinity to many DNA lesions and once bound autocatalyze the generation of a PAR polymer which induces chromatin decondensation and recruits many other ...
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Characterisation of unusual DNA glycosylases from Trichomonas vaginalis
... Human DNA repair enzymes involved in base excision repair, mismatch repair, non- homologous end joining, and homologous recombination were identified and used to find possible ...
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Functional studies of accessory factors associated with base excision repair
... In our functional evaluation of XRCC1 polymorphisms, we determined that relative to the wild-type protein the 280His variant decreased the DNA repair capacity of mammalian cells exposed to chemical ...
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The nexus of vitamin homeostasis and DNA synthesis and modification in mammalian brain
... in DNA which is the most abundant in ...in DNA, prior to glycosylase removal and base excision repair, helps explain many heretofore unexplained phenomena in brain including: 1) the ...
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The Relative Roles of Three DNA Repair Pathways in Preventing Caenorhabditis elegans Mutation Accumulation
... three excision repair pathways in eukaryotes has benefited from decades of intense study from a variety of biochemical and molecular genetic ap- proaches, primarily in Saccharomyces cerevisiae and mam- ...
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A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA
... oxoguanine DNA glycosylase 1 (hOgg1) ...mutagenic base 8-oxoguanine (oxoG) from the human genome ...of DNA by hOgg1 to locate oxoG residues is made difficult not only by the vast excess of ...
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Role of Repair Enzymes - Damage Control of DNA From Ageing pans
... Base excision repair (BER) involves multiple enzymes to excise and replace a single damaged nucleotide ...The base modifications primarily repaired by BER enzymes are those damaged by ...
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Why Is DNA Double Stranded? The Discovery of DNA Excision Repair Mechanisms
... to DNA repair held in Chicago in 1965 (Haynes et ...in excision repair (Reiter and Strauss 1965) since, along with other evidence, this strain did not repair UV-induced or nitrogen ...
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Clinical Significance of a Point Mutation in DNA Polymerase Beta (POLB) Gene in Gastric Cancer
... in DNA repair genes can modulate DNA repair capability and, consequently, have been associated with risk of developing ...in DNA polymerase beta (POLB) gene, a key enzyme involved in ...
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Use of uracil-DNA glycosylase enzyme to reduce DNA-related artifacts from formalin-fixed and paraffin-embedded tissues in diagnostic routine
... of DNA damage generated in FFPE tissues, including deamin- ation of cytosine to uracil or deamination of 5- methylcytosine (5-mC) to thymine ...in DNA, which con- tributes significantly to the appearance of ...
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The XPC-hHR23b complex and nucleotide excision repair of DNA
... corrects base m isincorporation errors after DNA synthesis and also acts on m ispaired bases th at can occur in recom bination interm ...1992). Repair is initiated only on the new ly synthesized ...
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